公开(公告)号：US20150080567A1

公开(公告)日：2015-03-19

申请号：US14471593

申请日：2014-08-28

申请人： Nalas Engineering Services Inc.

发明人： Jerry Salan ,  Stephen R. Anderson ,  David J. am Ende

IPC分类号： C30B30/06 ,  C07D213/82 ,  C07D487/18 ,  C07D257/02 ,  C30B1/12 ,  C07C47/54 ,  C07C229/60 ,  B01F11/00 ,  B01F3/18 ,  C30B7/14 ,  C07D225/08 ,  C07D213/38

CPC分类号： C30B30/06 ,  B01F3/18 ,  B01F11/008 ,  B01F2215/0032 ,  C06B21/0066 ,  C06B25/34 ,  C07B2200/13 ,  C07C47/54 ,  C07C229/60 ,  C07D213/38 ,  C07D213/82 ,  C07D223/26 ,  C07D225/08 ,  C07D257/02 ,  C07D487/18 ,  C07D487/22 ,  C30B1/12 ,  C30B7/14

摘要： A method to produce and manufacture cocrystals and salts is disclosed wherein crystalline solids and other components were combined in the desired proportions into a mixing chamber and mixed at high intensity to afford a cocrystalline product. No grinding media were required. The mixing system consists of a resonant acoustic vibratory system capable of supplying a large amount of energy to the mixture and is tunable to a desired resonance frequency and amplitude. The use of resonant acoustic mixing to assist cocrystallization is novel. This discovery enables the manufacture of cocrystals and salt forms, simplifying their manufacture and scale-up, and avoiding the use of grinding methods or grinding media. The present invention affords the manufacture of cocrystals and salts on kilogram to multi-ton scale and is adaptable to continuous manufacturing through the use of resonant mixing methods.

摘要翻译： 公开了一种生产和制造共晶体和盐的方法，其中将结晶固体和其它组分以所需比例合并到混合室中并以高强度混合以提供共晶产物。 不需要研磨介质。 混合系统由能够向混合物提供大量能量并且可调谐到期望的共振频率和振幅的共振声振动系统组成。 使用共振声学混合来辅助共结晶是新颖的。 这一发现使得能够制造共晶和盐形式，简化其制造和放大，并避免使用研磨方法或研磨介质。 本发明提供以千吨至多吨规模生产共晶和盐，并且通过使用共振混合方法适应于连续制造。

公开(公告)号：US20080029020A1

公开(公告)日：2008-02-07

申请号：US11828488

申请日：2007-07-26

申请人： Shin SUGAWARA ,  Eigo TAKAHASHI ,  Hisao ARIMUNE

发明人： Shin SUGAWARA ,  Eigo TAKAHASHI ,  Hisao ARIMUNE

IPC分类号： C30B30/06

CPC分类号： C30B29/06 ,  C30B29/60 ,  C30B30/08 ,  Y10T117/1024

摘要： A method for producing a granular crystal includes steps of melting a crystal to be a molten solution, ejecting a droplet of the molten solution from a nozzle with a three dimensional motion. An apparatus for producing a granular crystal includes a crucible, an actuator, and at least one nozzle. The crucible contains a molten solution of a crystal. The actuator moves at least one nozzle with three-dimensional motion. At least one nozzle ejects a droplet of the molten solution with a three dimensional motion.

摘要翻译： 制造粒状晶体的方法包括以下步骤：将晶体熔化为熔融溶液，以三维运动从喷嘴喷射熔融液滴。 一种颗粒状晶体的制造装置包括坩埚，致动器和至少一个喷嘴。 坩埚含有晶体的熔融溶液。 致动器至少移动一个具有三维运动的喷嘴。 至少一个喷嘴以三维运动喷射熔融溶液的液滴。

公开(公告)号：US10156026B2

公开(公告)日：2018-12-18

申请号：US14999312

申请日：2016-04-22

申请人： Daniel Smith

发明人： Daniel Smith

IPC分类号： C30B30/06 ,  C30B7/10 ,  C30B9/00 ,  C30B29/22 ,  C30B29/18 ,  C30B29/20

摘要： The purpose of diffusion assisted crystal hydrothermal growth is to facilitate a greatly increased crystal growth rate that would save time that is precious in such a material and manpower costly process. The assisted crystal growth itself requires the utilization of a piezoelectric shaker connected to the autoclave in which most industrial hydrothermal crystals are grown. The waveform can be modulated to induce transport of nutrient in a singular direction, customized to the topology of the apparatus. As it stands currently, the growth of most crystals that require autoclaves for their production can take anywhere from 3 months to up to 2 years, and accordingly carries many costs, particularly electricity and supervision of the autoclave(s), and other issues that may arise during the growth. While the product of this labor results in high-quality crystals, in reality, these are not at all what is needed outside of the laboratory environment. Using the assisted crystal hydrothermal growth process, average crystal growth can be cut in half, with the resulting crystals consequently being of a slightly lower quality, though still sufficient for most engineering purposes. Another advantage of using a piezoelectric shaker is that an additional sensor can be added to the autoclave to monitor the health of the autoclave using trending data obtained during the growth.

公开(公告)号：US20150018357A1

公开(公告)日：2015-01-15

申请号：US14373262

申请日：2012-12-17

申请人： LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO. LTD.

发明人： Zheqing Wang ,  Yongzhi Cheng ,  Heng Huang ,  Huizhen Li

IPC分类号： C30B30/06 ,  C30B29/54 ,  C07D475/04 ,  C30B7/14 ,  A23L1/30 ,  A61K31/519

CPC分类号： C30B30/06 ,  A23L33/10 ,  A23L33/155 ,  A23V2002/00 ,  A61K31/519 ,  C07B2200/13 ,  C07D475/04 ,  C30B7/14 ,  C30B29/54

摘要： Disclosed are a crystal form of (6S)-5-methyltetrahydrofolate salt and a method for preparing the same. The crystal form is: Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.3±0.2 and 19.2±0.2; or the crystal form of (6S)-5-methyltetrahydrofolate strontium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.5±0.2 and 22.0±0.2. The crystal form of (6S)-5-methyltetrahydrofolate salt of the present invention has the advantages of excellent physicochemical properties, good stability, high purity, good reproducibility, and being more suitable for production on an industrial scale.

摘要翻译： 公开了（6S）-5-甲基四氢叶酸盐的晶体形式及其制备方法。 晶体形式为：（6S）-5-甲基四氢叶酸钙盐晶型的晶型C，其中X射线衍射图在2θ处具有衍射峰; 角度为6.3±0.2和19.2±0.2; 或（6S）-5-甲基四氢叶酸锶盐的晶体形式，其中X射线衍射图在2θ处具有衍射峰; 角度为6.5±0.2和22.0±0.2。 本发明（6S）-5-甲基四氢叶酸盐的晶体形式具有物理化学性质好，稳定性好，纯度高，再现性好，更适合工业规模生产的优点。

公开(公告)号：US11473213B2

公开(公告)日：2022-10-18

申请号：US16957593

申请日：2018-12-28

申请人： D. Swarovski KG

发明人： Christian Gabl ,  Christian Lipp ,  Nina Stepanik ,  Christina Streiter ,  Roy Layne Howell ,  Georg Czermak ,  Matthias Gander ,  Wolfgang Stiglitz

IPC分类号： C30B30/06 ,  C01B33/12 ,  C30B29/16 ,  C30B29/60 ,  C30B35/00 ,  B82Y20/00 ,  B82Y40/00 ,  G02B1/00 ,  G02B6/122

摘要： A method of making a liquid dispersion for the manufacture of a photonic crystal. The method comprises dispersing monodispersed spheres in a liquid to form a liquid dispersion, and subjecting the liquid dispersion to an ultrasonic treatment. Ammonia solution may also be added to the liquid dispersion. The ultrasound treatment breaks up agglomerations of monodispersed spheres, and the resulting photonic crystal made using the dispersion is more highly ordered and hence of higher quality.

公开(公告)号：US20090178933A1

公开(公告)日：2009-07-16

申请号：US12353912

申请日：2009-01-14

申请人： Taofang Zeng

发明人： Taofang Zeng

IPC分类号： C30B30/06 ,  B29B9/00

CPC分类号： C25C5/02 ,  B22F2998/00 ,  B22F2999/00 ,  C25B1/00 ,  C25B9/125 ,  C25C7/007 ,  B22F1/0018 ,  B22F9/24

摘要： A method for making nanoparticles or fine particles includes (1) in an electrolysis cell, supplying a power (potentiostat) to an element that acts as a counter electrode, and another element that is working electrode; and rubbing the working electrode to make nanoparticles or fine particles. Another method for making nanoparticles or fine particles includes (1) in an electrolysis cell, supplying a power (potentiostat) to an element that acts as a counter electrode, and another element that is working electrode; and (2) mechanically vibrating the working electrode to make nanoparticles or fine particles.

摘要翻译： 制备纳米颗粒或细颗粒的方法包括（1）在电解槽中，向用作对电极的元件供给电力（恒电位仪），以及作为工作电极的另一元件; 并摩擦工作电极以制备纳米颗粒或细颗粒。 制备纳米颗粒或细颗粒的另一种方法包括（1）在电解槽中，向用作对电极的元件供给功率（恒电位仪），以及作为工作电极的另一元件; 和（2）机械地振动工作电极以制备纳米颗粒或细颗粒。

公开(公告)号：US20200347517A1

公开(公告)日：2020-11-05

申请号：US16957593

申请日：2018-12-28

申请人： D. Swarovski KG

发明人： Christian Gabl ,  Christian Lipp ,  Nina Stepanik ,  Christina Streiter ,  Roy Layne Howell ,  Georg Czermak ,  Matthias Gander ,  Wolfgang Stiglitz

IPC分类号： C30B30/06 ,  C01B33/12 ,  C30B35/00 ,  C30B29/16 ,  C30B29/60

摘要： A method of making a liquid dispersion for the manufacture of a photonic crystal. The method comprises dispersing monodispersed spheres in a liquid to form a liquid dispersion, and subjecting the liquid dispersion to an ultrasonic treatment. Ammonia solution may also be added to the liquid dispersion. The ultrasound treatment breaks up agglomerations of monodispersed spheres, and the resulting photonic crystal made using the dispersion is more highly ordered and hence of higher quality.

公开(公告)号：US10172361B2

公开(公告)日：2019-01-08

申请号：US14889740

申请日：2014-05-05

申请人： Bar-Ilan University

发明人： Aharon Gedanken ,  Ehud Banin ,  Ilana Perelshtein ,  Rachel Lubart ,  Anat Lipovsky ,  Eyal Malka ,  Nitzan Yeshayahu ,  Nina Perkas ,  Yakov Shalom ,  Jonathan Lellouche ,  Tal Patick ,  Michal Eshed ,  Livnat Naparstek

IPC分类号： A01N59/20 ,  B82Y30/00 ,  C30B29/16 ,  C30B7/14 ,  C30B29/60 ,  C30B30/06 ,  A61L26/00 ,  A61L29/12 ,  A61L29/16 ,  A61L15/44 ,  A01N59/16 ,  C01G3/00 ,  C04B35/053 ,  C04B35/45 ,  C01G9/00 ,  C01G9/02 ,  C01F5/02

摘要： Nanoparticle composites comprised of a metal oxide and ions of a metallic element included within a crystal lattice of said metal oxide are disclosed. Process of preparing the nanoparticle composites per se and incorporated in or on a substrate are also disclosed. Uses of the nanoparticle composites and of substrates incorporating same, particularly for reducing a formation of a load of a microorganism or of a biofilm, are also disclosed.

公开(公告)号：US20170306525A1

公开(公告)日：2017-10-26

申请号：US14999312

申请日：2016-04-22

申请人： Daniel Smith

发明人： Daniel Smith

IPC分类号： C30B30/06 ,  C30B29/18 ,  C30B7/10 ,  C30B9/00 ,  C30B29/22 ,  C30B29/20

CPC分类号： C30B29/18 ,  C30B7/10 ,  C30B9/10 ,  C30B29/22

摘要： The purpose of diffusion assisted crystal hydrothermal growth is to facilitate a greatly increased crystal growth rate that would save time that is precious in such a material and manpower costly process. The assisted crystal growth itself requires the utilization of a piezoelectric shaker connected to the autoclave in which most industrial hydrothermal crystals are grown. The waveform can be modulated to induce transport of nutrient in a singular direction, customized to the topology of the apparatus. As it stands currently, the growth of most crystals that require autoclaves for their production can take anywhere from 3 months to up to 2 years, and accordingly carries many costs, particularly electricity and supervision of the autoclave(s), and other issues that may arise during the growth. While the product of this labor results in high-quality crystals, in reality, these are not at all what is needed outside of the laboratory environment. Using the assisted crystal hydrothermal growth process, average crystal growth can be cut in half, with the resulting crystals consequently being of a slightly lower quality, though still sufficient for most engineering purposes. Another advantage of using a piezoelectric shaker is that an additional sensor can be added to the autoclave to monitor the health of the autoclave using trending data obtained during the growth.

公开(公告)号：US09150982B2

公开(公告)日：2015-10-06

申请号：US14373262

申请日：2012-12-17

申请人： LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO. LTD.

发明人： Zheqing Wang ,  Yongzhi Cheng ,  Heng Huang ,  Huizhen Li

IPC分类号： C07D475/04 ,  C30B30/06 ,  A23L1/30 ,  A61K31/519 ,  C30B7/14 ,  C30B29/54 ,  A23L1/303

CPC分类号： C30B30/06 ,  A23L33/10 ,  A23L33/155 ,  A23V2002/00 ,  A61K31/519 ,  C07B2200/13 ,  C07D475/04 ,  C30B7/14 ,  C30B29/54

摘要： Disclosed are a crystal form of (6S)-5-methyltetrahydrofolate salt and a method for preparing the same. The crystal form is: Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.3±0.2 and 19.2±0.2; or the crystal form of (6S)-5-methyltetrahydrofolate strontium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.5±0.2 and 22.0±0.2. The crystal form of (6S)-5-methyltetrahydrofolate salt of the present invention has the advantages of excellent physicochemical properties, good stability, high purity, good reproducibility, and being more suitable for production on an industrial scale.

摘要翻译： 公开了（6S）-5-甲基四氢叶酸盐的晶体形式及其制备方法。 晶体形式为：（6S）-5-甲基四氢叶酸钙盐晶型的晶型C，其中X射线衍射图在2θ处具有衍射峰; 角度为6.3±0.2和19.2±0.2; 或（6S）-5-甲基四氢叶酸锶盐的晶体形式，其中X射线衍射图在2θ处具有衍射峰; 角度为6.5±0.2和22.0±0.2。 本发明（6S）-5-甲基四氢叶酸盐的晶体形式具有物理化学性质好，稳定性好，纯度高，再现性好，更适合工业规模生产的优点。