公开(公告)号：US06426072B1

公开(公告)日：2002-07-30

申请号：US09643597

申请日：2000-08-21

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

IPC分类号： A61K3900

CPC分类号： C07K16/3023

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US07049063B2

公开(公告)日：2006-05-23

申请号：US09735705

申请日：2000-12-12

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill ,  Neil Fanger

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill ,  Neil Fanger

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/3023 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/6068 ,  C07K14/47 ,  C07K2317/21 ,  C07K2319/00 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

公开(公告)号：US06821519B2

公开(公告)日：2004-11-23

申请号：US10237551

申请日：2002-09-06

申请人： Craig H. Day ,  Nancy A. Hosken ,  Joseph M. Parsons

发明人： Craig H. Day ,  Nancy A. Hosken ,  Joseph M. Parsons

IPC分类号： A61K39245

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/00 ,  C12N2710/16622 ,  G01N33/56994 ,  G01N2333/035

摘要： Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.

摘要翻译： 提供了用于诊断和治疗HSV感染的化合物和方法。 所述化合物包含含有HSV多肽的至少一个抗原部分的多肽和编码此类多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 还提供了诊断试剂盒，其包含这样的多肽和/或DNA序列和用于在患者和生物样品中检测HSV感染的合适的检测试剂。

公开(公告)号：US06737514B1

公开(公告)日：2004-05-18

申请号：US09630940

申请日：2000-08-02

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

IPC分类号： C07K1600

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K16/3023 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于检测样品中的肺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06531315B1

公开(公告)日：2003-03-11

申请号：US09606421

申请日：2000-06-28

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky

IPC分类号： C12N508

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K2319/00 ,  C12Q1/6809

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US07037509B2

公开(公告)日：2006-05-02

申请号：US10882074

申请日：2004-06-30

申请人： David M. Koelle ,  Nancy A. Hosken ,  Christine M. Posavad ,  Hongbo Chen ,  Patrick McGowan

发明人： David M. Koelle ,  Nancy A. Hosken ,  Christine M. Posavad ,  Hongbo Chen ,  Patrick McGowan

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K2039/5154 ,  A61K2039/57 ,  C12N2710/16622

摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

公开(公告)号：US06814969B2

公开(公告)日：2004-11-09

申请号：US10210428

申请日：2002-07-31

申请人： David M. Koelle ,  Nancy A. Hosken ,  Christine M. Posavad ,  Hongbo Chen ,  Patrick McGowan

发明人： David M. Koelle ,  Nancy A. Hosken ,  Christine M. Posavad ,  Hongbo Chen ,  Patrick McGowan

IPC分类号： A61K39245

CPC分类号： C07K14/005 ,  A61K2039/5154 ,  A61K2039/57 ,  C12N2710/16622

摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

摘要翻译： 本发明提供可用于预防和治疗HSV感染的HSV抗原。 本文公开了证实由来自疱疹病变的T细胞识别的表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

公开(公告)号：US06706262B1

公开(公告)日：2004-03-16

申请号：US09476496

申请日：1999-12-30

申请人： Tongtong Wang ,  Nancy A. Hosken ,  Michael D. Kalos ,  Gary R. Fanger

发明人： Tongtong Wang ,  Nancy A. Hosken ,  Michael D. Kalos ,  Gary R. Fanger

IPC分类号： A01N6300

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K2319/00 ,  C12Q1/6809

摘要： Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

公开(公告)号：US06537555B2

公开(公告)日：2003-03-25

申请号：US09894998

申请日：2001-06-28

申请人： Nancy A. Hosken ,  Craig H. Day ,  Davin C. Dillon ,  Patrick McGowan ,  Paul R. Sleath

发明人： Nancy A. Hosken ,  Craig H. Day ,  Davin C. Dillon ,  Patrick McGowan ,  Paul R. Sleath

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/00 ,  C12N2710/16622 ,  G01N2333/035

摘要： Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.

公开(公告)号：US06518256B1

公开(公告)日：2003-02-11

申请号：US09542615

申请日：2000-04-04

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger

IPC分类号： A01N4304

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K2319/00 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.