公开(公告)号：US20080292633A1

公开(公告)日：2008-11-27

申请号：US11929565

申请日：2007-10-30

申请人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

发明人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K14/00 ,  C12N15/00 ,  C12N5/00 ,  A61K35/12 ,  C07K16/00 ,  G01N33/574 ,  C12N5/02

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US20080171048A1

公开(公告)日：2008-07-17

申请号：US11929572

申请日：2007-10-30

申请人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

发明人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06667154B1

公开(公告)日：2003-12-23

申请号：US09671325

申请日：2000-09-26

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06509448B2

公开(公告)日：2003-01-21

申请号：US09736457

申请日：2000-12-13

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan ,  Aijun Wang

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan ,  Aijun Wang

IPC分类号： C07K1618

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S977/911 ,  Y10S977/912 ,  Y10S977/916

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US07579160B2

公开(公告)日：2009-08-25

申请号：US10922124

申请日：2004-08-19

申请人： Chaitanya S. Bangur ,  Barbara K. Zehentner-Wilkinson

发明人： Chaitanya S. Bangur ,  Barbara K. Zehentner-Wilkinson

IPC分类号： G01N33/53 ,  C07K1/26 ,  C12Q1/00

CPC分类号： G01N33/57411 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/545 ,  C07K14/47 ,  C07K14/4748 ,  C07K16/3023 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/40 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10371 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/5088 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

公开(公告)号：US06504010B1

公开(公告)日：2003-01-07

申请号：US09702705

申请日：2000-10-30

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US20110177082A1

公开(公告)日：2011-07-21

申请号：US13009413

申请日：2011-01-19

申请人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

发明人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K14/00 ,  C07K7/00 ,  C07K16/00 ,  A61K31/7088 ,  A61K38/00 ,  A61K35/12 ,  A61K39/00 ,  A61P35/00 ,  C12N15/63 ,  G01N33/68 ,  C12N5/0783 ,  G01N33/53 ,  G01N33/566 ,  C12N1/00 ,  C12N5/10

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/4748 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US06933363B1

公开(公告)日：2005-08-23

申请号：US09519642

申请日：2000-03-06

申请人： Tongtong Wang ,  Chaitanya S. Bangur

发明人： Tongtong Wang ,  Chaitanya S. Bangur

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  A61K38/16

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise cancer-associated L552S polypeptides, for example, as set forth illustratively in SEQ ID NO:786, or portions or variants thereof. Such compositions may be used, for example, in the diagnosis, prevention, and treatment of diseases such as lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物，例如肺癌。 组合物可以包含与癌症相关的L552S多肽，例如，如SEQ ID NO：786所示，或其部分或变体。 这样的组合物可以用于例如诊断，预防和治疗诸如肺癌的疾病。

公开(公告)号：US06630574B1

公开(公告)日：2003-10-07

申请号：US09614124

申请日：2000-07-11

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： A61K3816

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.

摘要翻译： 公开了包含分离的癌相关L552S多肽的组合物。 这样的组合物可以包括例如所述癌相关L552S多肽的部分和/或编码这些部分的相应多核苷酸。 还提供了组合物的说明性用途，例如癌症诊断方法。

公开(公告)号：US06426072B1

公开(公告)日：2002-07-30

申请号：US09643597

申请日：2000-08-21

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

IPC分类号： A61K3900

CPC分类号： C07K16/3023

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.