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公开(公告)号:US07211278B2
公开(公告)日:2007-05-01
申请号:US10777976
申请日:2004-02-13
申请人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
发明人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
CPC分类号: A61Q7/02 , A61K8/046 , A61K8/14 , A61K8/66 , A61K8/97 , A61K36/15 , A61K36/8998 , A61K38/4826 , A61K38/4873 , A61K2800/782 , A61K2300/00
摘要: treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.
摘要翻译: 治疗毛发生长抑制的方法,其包括施用(A)桧属a属植物的提取物或麦芽。 另外,本发明涉及外用皮肤病学组合物,其包含(B)弹性蛋白酶抑制剂或中性肽链内切酶抑制剂,以及上述成分(A)和/或(C)至少一种选自以下的蛋白水解酶 由木瓜蛋白酶,胰蛋白酶,糜蛋白酶,胃蛋白酶,菠萝蛋白酶,蓖麻毒素和胰酶组成的组。
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公开(公告)号:US07189708B2
公开(公告)日:2007-03-13
申请号:US10252057
申请日:2002-09-23
申请人: Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
发明人: Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
IPC分类号: A61K31/545
CPC分类号: C07C237/20 , A61K38/05
摘要: A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.
摘要翻译: 含有由式(1)表示的二肽化合物或二肽盐的局部皮肤组合物:其中R 1表示氢原子,烷基,烷酰基或-CH(R' 其中R 6表示氢原子或低级烷基,R 7表示氢原子或低级烷基, 氢原子,低级烷基,低级烯基或芳烷基)。 R 2表示氢原子或可以具有取代基的烷基; R 3表示低级烷基或苯基; R 4表示氢原子或低级烷基,并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子,可以具有取代基的烷基或可具有取代基的芳烷基,并且可以与R 4一起形成杂环, ; X表示-COOR 8(其中R 8表示氢原子,低级烷基,低级烯基或芳烷基)或-SO 3 H; 并且n是0-4的整数; 和其药学上可接受的载体。
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公开(公告)号:US08282946B2
公开(公告)日:2012-10-09
申请号:US11246218
申请日:2005-10-11
申请人: Yusuke Shibuya , Shigeru Moriwaki , Naoko Tsuji
发明人: Yusuke Shibuya , Shigeru Moriwaki , Naoko Tsuji
CPC分类号: A61Q19/00 , A61K8/97 , A61K36/9068 , A61K2800/75 , A61Q7/02
摘要: Provided are a water-soluble ginger root extract which is a water extract or a hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and a preparation for external use each containing the extract. The water-soluble ginger root extract of the present invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and a preparation for external use, each having a high degree of safety.
摘要翻译: 提供一种水溶性姜根提取物,其是姜根的水提取物或含水醇提取物,并且基本上不含姜酚; 和含有提取物的毛发生长抑制剂和外用制剂。 本发明的水溶性姜根提取物由于基本上不含姜酚而引起皮肤刺激性较差,并且具有优异的身体毛发生长抑制效果,因此可用作头发生长抑制剂和外用制剂, 每个都具有高度的安全性。
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公开(公告)号:US07504116B2
公开(公告)日:2009-03-17
申请号:US10973452
申请日:2004-10-27
IPC分类号: A61K36/00
摘要: The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment.Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译: 本发明涉及一种毛发生长抑制剂和脱毛促进剂,每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡,紫苏,莱氏根和白僵菌的生药,或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛,从而降低脱毛处理的频率。 此外,它使得头发主体更细,从而便于从脚或手臂去除头发。
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公开(公告)号:US20060099280A1
公开(公告)日:2006-05-11
申请号:US11246218
申请日:2005-10-11
申请人: Yusuke Shibuya , Shigeru Moriwaki , Naoko Tsuji
发明人: Yusuke Shibuya , Shigeru Moriwaki , Naoko Tsuji
IPC分类号: A61K36/9068
CPC分类号: A61Q19/00 , A61K8/97 , A61K36/9068 , A61K2800/75 , A61Q7/02
摘要: Provided are a water-soluble ginger root extract which is a water extract or a hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and a preparation for external use each containing the extract. The water-soluble ginger root extract of the present invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and a preparation for external use, each having a high degree of safety.
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公开(公告)号:US20060093567A1
公开(公告)日:2006-05-04
申请号:US11311170
申请日:2005-12-20
申请人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号: A61K8/65
CPC分类号: A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要: Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and-use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译: 本文公开了抑制毛发生长的方法,其包括施用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂,以及使用弹性蛋白酶样酶抑制剂或中性内肽酶抑制剂来制备毛发生长 抑制剂。
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公开(公告)号:US20050053573A1
公开(公告)日:2005-03-10
申请号:US10973452
申请日:2004-10-27
摘要: The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译: 本发明涉及一种毛发生长抑制剂和脱毛促进剂,每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡,紫苏,莱氏根和白僵菌的生药,或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛,从而降低脱毛处理的频率。 此外,它使得头发主体更细,从而便于从脚或手臂去除头发。
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公开(公告)号:US07056499B2
公开(公告)日:2006-06-06
申请号:US10067941
申请日:2002-02-08
申请人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
发明人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
CPC分类号: A61Q7/02 , A61K8/046 , A61K8/14 , A61K8/66 , A61K8/97 , A61K36/15 , A61K36/8998 , A61K38/4826 , A61K38/4873 , A61K2800/782 , A61K2300/00
摘要: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.
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公开(公告)号:US06747017B2
公开(公告)日:2004-06-08
申请号:US09220691
申请日:1998-12-28
申请人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人: Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号: A01N5726
CPC分类号: A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要: Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译: 本文公开了一种抑制毛发生长的方法,其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂,以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂 。
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公开(公告)号:US07488499B2
公开(公告)日:2009-02-10
申请号:US10246466
申请日:2002-09-19
IPC分类号: A61K36/00
摘要: The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhel Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.
摘要翻译: 本发明涉及一种毛发生长抑制剂和脱毛促进剂,每种毛发生长抑制剂和去毛刺促进剂均含有选自柴胡,紫苏,枸杞子和Akebiae Caulis的生药,或其提取物。 这种抑制剂或促进剂可以分别抑制体毛的生长或促进脱毛,从而降低脱毛处理的频率。 此外,它使得头发主体更细,从而便于从脚或手臂去除头发。
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