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15 条记录 (耗时 0.023 秒)

    Topical composition for skin
    1.
    发明授权
    Topical composition for skin 有权
    皮肤专题组成

    公开(公告)号：US07189708B2

    公开(公告)日：2007-03-13

    申请号：US10252057

    申请日：2002-09-23

    申请人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

    发明人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

    IPC分类号： A61K31/545

    CPC分类号： C07C237/20 ,  A61K38/05

    摘要： A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.

    摘要翻译： 含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R 1表示氢原子，烷基，烷酰基或-CH（R' 其中R 6表示氢原子或低级烷基，R 7表示氢原子或低级烷基， 氢原子，低级烷基，低级烯基或芳烷基）。 R 2表示氢原子或可以具有取代基的烷基; R 3表示低级烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或可具有取代基的芳烷基，并且可以与R 4一起形成杂环， ; X表示-COOR 8（其中R 8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO 3 H; 并且n是0-4的整数; 和其药学上可接受的载体。

    Topical composition for skin
    2.
    发明授权
    Topical composition for skin 有权
    皮肤专题组成

    公开(公告)号：US06489291B1

    公开(公告)日：2002-12-03

    申请号：US09678615

    申请日：2000-10-04

    申请人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

    发明人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

    IPC分类号： A01N3718

    CPC分类号： C07C237/20 ,  A61K38/05

    摘要： A topical skin composition containing a dipeptide compound represented by, formula (1) or a salt of the dipeptide: wherein R1 represents a, hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.

    摘要翻译： 含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R1表示氢原子，烷基，烷酰基或-CH（R6）COOR7（其中R6表示 氢原子或低级烷基，R7表示氢原子，低级烷基，低级烯基或芳烷基）; R2表示氢原子或可具有取代基的烷基; R3表示低级 烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或 可以具有取代基的芳烷基，也可以与R4形成杂环; X表示-COOR8（其中R8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO3H; andn是0-4的整数; 和其药学上可接受的载体。

    Treating method for suppressing hair growth
    9.
    发明授权
    Treating method for suppressing hair growth 有权
    抑制毛发生长的处理方法

    公开(公告)号：US06375948B1

    公开(公告)日：2002-04-23

    申请号：US09614166

    申请日：2000-07-11

    申请人： Naoko Tsuji ,  Shigeru Moriwaki ,  Atsushi Ohuchi ,  Yasuto Suzuki

    发明人： Naoko Tsuji ,  Shigeru Moriwaki ,  Atsushi Ohuchi ,  Yasuto Suzuki

    IPC分类号： A61K3848

    CPC分类号： A61Q7/02 ,  A61K8/046 ,  A61K8/14 ,  A61K8/66 ,  A61K8/97 ,  A61K36/15 ,  A61K36/8998 ,  A61K38/4826 ,  A61K38/4873 ,  A61K2800/782 ,  A61K2300/00

    摘要： The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

    摘要翻译： 本发明涉及一种用于毛发生长抑制的处理方法，其包括给予（A）桧属家a或麦芽的植物提取物。 另外本发明涉及外用皮肤病学组合物，其包含（B）弹性蛋白酶抑制剂或中性肽链内切酶抑制剂，以及上述成分（A）和/或（C）至少一种选自以下的蛋白水解酶 由木瓜蛋白酶，胰蛋白酶，糜蛋白酶，胃蛋白酶，菠萝蛋白酶，蓖麻毒素和胰酶组成的组。