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公开(公告)号:US08193351B2
公开(公告)日:2012-06-05
申请号:US12302149
申请日:2007-05-25
申请人: Takuo Tsukuda , Ken-Ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
发明人: Takuo Tsukuda , Ken-Ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
IPC分类号: C07D239/47 , C07D251/42 , A61K31/506 , A61K31/53 , A61P35/00
CPC分类号: C07D251/16 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要翻译: 提供了由下式(1)表示的化合物及其药学上可接受的盐,以及包含这些化合物的药物组合物。
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公开(公告)号:US20090247524A1
公开(公告)日:2009-10-01
申请号:US12302149
申请日:2007-05-25
申请人: Takuo Tsukuda , Ken-ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
发明人: Takuo Tsukuda , Ken-ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
IPC分类号: A61K31/5377 , C07D251/16 , A61K31/53 , C07D311/78 , C07D239/02 , A61K31/505 , C07D413/02 , A61P35/00
CPC分类号: C07D251/16 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要翻译: 提供了由下式(1)表示的化合物及其药学上可接受的盐,以及包含这些化合物的药物组合物。
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公开(公告)号:US08362236B2
公开(公告)日:2013-01-29
申请号:US12529222
申请日:2008-02-29
申请人: Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-Ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
发明人: Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-Ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
IPC分类号: C07D497/08 , C07D513/08 , C07D513/20 , A61K31/529 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号: C07D497/08 , C07D513/08 , C07D513/18 , C07D513/20
摘要: The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要翻译: 本发明提供具有抑制HSP90酶的活性的新型化合物,可用作抗癌剂等,以及可用作其合成中间体的化合物。 具体而言,本发明提供下述式(1)表示的化合物及其药学上可接受的盐:其中X,R1,R2,R3,R4,R5,R6,R7,L1,L2和L3如 规范。
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公开(公告)号:US20100056510A1
公开(公告)日:2010-03-04
申请号:US12529222
申请日:2008-02-29
申请人: Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
发明人: Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
IPC分类号: A61K31/519 , C07D513/04 , A61P35/00 , A61K31/5377
CPC分类号: C07D497/08 , C07D513/08 , C07D513/18 , C07D513/20
摘要: The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要翻译: 本发明提供具有抑制HSP90酶的活性的新型化合物,可用作抗癌剂等,以及可用作其合成中间体的化合物。 具体而言,本发明提供下述式(1)表示的化合物及其药学上可接受的盐:其中X,R1,R2,R3,R4,R5,R6,R7,L1,L2和L3如 规范。
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