摘要:
The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要:
The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要:
Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要:
Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要:
Azole derivatives of the formula I wherein R14, R15 are each independently hydrogen or fluorine, T is a group of the formula: wherein R9 is pyrrolidinyl or a group A—NH—B—, A is hydrogen or straight-chain or branched C1-C5 alkyl; B is straight-chain or branched C1-C4 alkylene, —CH2—CONH—CH2 or —CH2CH2CH2—CH(NH2); and X− is a pharmaceutically acceptable anion; and pharmaceutically acceptable salts of said compounds, and hydrates and solvates of the compounds of formula I and the salts thereof can be used in the production of medicaments for treating fungal infections and mycoses.
摘要:
An endoscopic fluid control apparatus includes a cylinder which is attachable to an attachment part attached to an endoscope, and includes a first channel which transfers fluid to an insertion channel of the endoscope, a piston which is set on the cylinder and includes a valve part movable relative to the cylinder between a position where the first channel is opened relative to the insertion channel and a position where the first channel is closed relative to the insertion channel, a connection port part for connecting a fluid tube, and a second channel which transfers the fluid from the connection port part to the insertion channel, an elastic member which holds the piston to be movable relative to the cylinder between the position where the first channel is closed and the position where the first channel is opened, a first engagement part which engages the piston and the elastic member with each other so as not to rotate about an axis of movement of the piston, and a second engagement part which engages the cylinder and the elastic member with each other so as not to rotate about an axis of movement of the cylinder.The piston includes the valve part, a connection port part, and the second channel.
摘要:
The present invention is directed to a method for the treatment of cancer via the administration of a pharmaceutical composition, comprising at least one compound of formula (I) or a pharmaceutically acceptable salt of compound (I), in combination with capecitabine, trastuzumab, pertuzumab, cisplatin or irinotecan, or a pharmaceutically acceptable salt thereof, for simultaneous, sequential or separated administration in the treatment of cancer.
摘要:
An endoscope includes: an insertion portion configured to be inserted into a subject; an image pickup section configured to pick up an image of inside of the subject; an operation portion configured to be connected to the insertion portion; a grasping portion configured to be able to be grasped by an operator, the grasping portion being connected to the operation portion and provided such that an axis in a longitudinal direction is substantially perpendicular to a central axis of the insertion portion; a protruding portion provided on a surface on the insertion portion side of the grasping portion, the protruding portion protruding so as to form an acute angle with respect to the central axis of the insertion portion, on the insertion portion side; and a switch portion provided on the protruding portion and disposed at an angle which makes a right angle with respect to the acute angle.