公开(公告)号：US20100267072A1

公开(公告)日：2010-10-21

申请号：US12084242

申请日：2006-10-26

申请人： Naoyuki Inagaki ,  Tatsuya Mori ,  Osamu Ohara ,  Takahiro Nagase

发明人： Naoyuki Inagaki ,  Tatsuya Mori ,  Osamu Ohara ,  Takahiro Nagase

IPC分类号： C12Q1/02 ,  C07H21/02 ,  C12N15/00 ,  C12N5/02

CPC分类号： G01N33/5058 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/00

摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.

摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。 观察到，Singar在轴突末端的生长锥中高度富集。 当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。 因此，Singar的抑制可以诱导轴突形成。 因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。

公开(公告)号：US08076307B2

公开(公告)日：2011-12-13

申请号：US12084242

申请日：2006-10-26

申请人： Naoyuki Inagaki ,  Tatsuya Mori ,  Osamu Ohara ,  Takahiro Nagase

发明人： Naoyuki Inagaki ,  Tatsuya Mori ,  Osamu Ohara ,  Takahiro Nagase

IPC分类号： C12N15/11 ,  C12N15/00 ,  C07H21/04

CPC分类号： G01N33/5058 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/00

摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.

摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。 观察到，Singar在轴突末端的生长锥中高度富集。 当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。 因此，Singar的抑制可以诱导轴突形成。 因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。