公开(公告)号：US20050244821A1

公开(公告)日：2005-11-03

申请号：US10344650

申请日：2001-08-16

申请人： Ory Zik ,  Elisha Moses ,  Nava Levit-Binnun ,  Ariel Lindner

发明人： Ory Zik ,  Elisha Moses ,  Nava Levit-Binnun ,  Ariel Lindner

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/543 ,  G01N33/58 ,  G01N33/60

CPC分类号： G01N33/543 ,  G01N33/54373 ,  G01N33/587 ,  G01N2458/15 ,  H01J2237/1205 ,  H01J2237/2605

摘要： A method of detecting binding between first member or members of a binding pair and corresponding second member or members of the binding pair is disclosed. The method comprises interacting a solid support onto which the first member or members of the binding pair being immobilized and arrayed with the corresponding second member or members of the binding pair, the corresponding second member or members of the binding pair being directly or indirectly tagged with a heavy atom; and determining a spatial distribution of the heavy atom over a surface of the solid support, thereby detecting the binding between the first member or members of the binding pair and the corresponding second member or members of the binding pair.

摘要翻译： 公开了一种检测结合对的第一成员或成员与相应的第二成员或结合对的成员之间的结合的方法。 该方法包括使固体支持物相互作用，其中固定和排列结合对的第一个成员或其成员与相应的第二个成员或结合对的成员，其中相应的第二个成员或结合对的第二个成员被直接或间接标记 一个重的原子 以及确定所述固体支持物表面上所述重质原子的空间分布，从而检测所述结合对的第一成员或所述结合对的相应第二成员或所述结合对的成员之间的结合。