公开(公告)号：US20240139145A1

公开(公告)日：2024-05-02

申请号：US18547044

申请日：2022-02-18

申请人： NAVIN SAXENA RESEARCH AND TECHNOLOGY PRIVATE LIMITED

发明人： Kunal SAXENA ,  Navin SAXENA

IPC分类号： A61K31/33 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34

CPC分类号： A61K31/33 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34

摘要： The present invention discloses a sustained release non-aqueous injectable composition of buprenorphine, its metabolite, its prodrug, or its salt thereof for the treatment of moderate-to-severe pain and opioid dependence. The non-aqueous injectable composition includes one or more biocompatible non-aqueous solvents, one or more release retarding agents, one or more surfactants, one or more biodegradable polymers and one or more stabilizers. The buprenorphine composition of the present invention delivers buprenorphine over a period of about one week to 12 weeks after single administration which leads to better patient compliance by reducing the daily dose administration of buprenorphine. The present invention also provides an injectable composition with potentially less pain due to the use of smaller gauge needles wherein the suitable gauge of needle may be 23 gauge to 30 gauge with a length of 8 to 30 mm. The preferred size of needle is 25 to 30 gauge.

公开(公告)号：US20240148647A1

公开(公告)日：2024-05-09

申请号：US18547025

申请日：2022-02-19

申请人： NAVIN SAXENA RESEARCH AND TECHNOLOGY PRIVATE LIMITED

发明人： Kunal SAXENA ,  Navin SAXENA

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K31/198 ,  A61K47/44 ,  A61P17/00

CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/198 ,  A61K47/44 ,  A61P17/00

摘要： The present invention discloses a topical cream composition of eflornithine or its pharmaceutically acceptable salts or prodrugs thereof with lavender oil as penetration enhancer and other excipients, which is effective to reduce the rate of skin hair growth and studies pertaining to pharmacodynamic behaviour thereof on hair growth rate. The invention further discloses a process for preparing a topical composition in the form of oil-in-water emulsion based cream composition which comprises eflornithine or its pharmaceutically acceptable salts or prodrugs thereof with a penetration enhancer and other excipients.

公开(公告)号：US20230391788A1

公开(公告)日：2023-12-07

申请号：US18250853

申请日：2021-10-27

申请人： NAVIN SAXENA RESEARCH & TECHNOLOGY PVT. LTD.

发明人： Kunal SAXENA ,  Aarkarsh SAXENA

IPC分类号： C07D489/09 ,  A61K47/44 ,  A61K47/10 ,  A61K9/00 ,  A61K47/34 ,  A61K31/485

CPC分类号： C07D489/09 ,  A61K47/44 ,  A61K47/10 ,  A61K9/0019 ,  A61K47/34 ,  A61K31/485

摘要： Disclosed herein is an improved process for preparation of naltrexone decanoate under a monophasic medium using a single solvent by esterifying naltrexone with a decanoyl chloride in the presence of an organic base, wherein the solvent is preferably cyclo-pentyl-methyl-ether (CPME) which is non-toxic in nature. The invention further discloses the elimination of an impurity bis-decanoyl naltrexone obtained during the preparation of naltrexone decanoate by preparing acid addition salts of naltrexone decanoate and reconverting into naltrexone decanoate from its acid addition salts by neutralizing using a base in the presence of suitable solvent to obtain naltrexone decanoate with a purity of more than 99% The invention also discloses pharmaceutical composition of naltrexone decanoate with at least one pharmaceutically acceptable excipient and method of use of naltrexone decanoate for the treatment of opioid dependence, alcohol dependence for a period of 7 days to 90 days in a patient in need thereof.

公开(公告)号：US20230357257A1

公开(公告)日：2023-11-09

申请号：US18342381

申请日：2023-06-27

申请人： NAVIN SAXENA RESEARCH & TECHNOLOGY PVT. LTD.

发明人： Dmitry Gorbachev ,  Hon Wai Lam ,  Aakarsh Saxena ,  Navin Satyapal Saxena

IPC分类号： C07D489/08

CPC分类号： C07D489/08

摘要： The present invention relates to a novel, efficient, pot- and atom-economical, and industrially applicable process for converting morphine to noroxymorphone using reagents and solvents of lesser toxicity and lower cost with respect to those used in the prior art.

公开(公告)号：US06366990B1

公开(公告)日：2002-04-02

申请号：US09211987

申请日：1998-12-14

申请人： Douglas A. Guddat ,  Glenn F. King ,  Tim Lambert ,  Navin Saxena ,  Peter J. DesRosier

发明人： Douglas A. Guddat ,  Glenn F. King ,  Tim Lambert ,  Navin Saxena ,  Peter J. DesRosier

IPC分类号： G06F1200

CPC分类号： G11C7/1045 ,  G11C2207/104 ,  G11C2207/2254

摘要： A method and apparatus for software controlled timing of embedded memory includes an embedded memory array and input/output (I/O) control circuitry coupled to the embedded memory array. The I/O control circuitry provides a plurality of I/O signals to the embedded memory array to control the input of data to the embedded memory array and output of data from the embedded memory array. The I/O control circuitry also includes programmable delay circuitry to alter the timing of the I/O signals.

摘要翻译： 用于嵌入式存储器的软件控制定时的方法和装置包括嵌入式存储器阵列和耦合到嵌入式存储器阵列的输入/输出（I / O）控制电路。 I / O控制电路向嵌入式存储器阵列提供多个I / O信号，以控制数据到嵌入式存储器阵列的输入以及从嵌入式存储器阵列输出数据。 I / O控制电路还包括可编程延迟电路，以改变I / O信号的时序。