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1.发明申请Histone Deacetylase (Hdac) Inhibitors (Pxd101) for the Treatment of Cancer Alone or in Combination With Chemotherapeutic Agent 有权组蛋白脱乙酰酶（Hdac）抑制剂（Pxd101）用于单独治疗癌症或与化疗药物组合公开(公告)号：US20080274120A1
公开(公告)日：2008-11-06
申请号：US12093069
申请日：2006-11-10
Applicant: Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
Inventor： Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
IPC: A61K31/395 , A61K31/195 , A61P35/02 , C12N5/00 , A61P35/00
CPC classification number: A61K31/475 , A61K31/10 , A61K31/185 , A61K31/196 , A61K31/573 , A61K31/65 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological cancer (e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof a therapeutically effective amount of a histone deacetylase inhibitor, for example, a histone deacetylase (HDAC) inhibitor as described herein, for example, PXD-101. In another respect, the present invention relates to a method of treating cancer (e.g., solid tumour cancer, e.g., rectal cancer, colon cancer, ovarian cancer; hematological cancer, e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof, a first amount of a histone deacetylase (HDAC) inhibitor, for example, a histone deacetylase inhibitor as described herein, for example, PXD-101, and a second amount of an other chemotherapeutic agent, for example, an other chemotherapeutic agent selected from: an antibody against VEGF, Avastin®, an antibody against CD20, rituximab, bortezomib, thalidomide, dexamethasone, vincristine, doxorubicin, and melphalan, wherein the first and second amounts together comprise a therapeutically effective amount.
Abstract translation: 本发明一般涉及治疗癌症的方法。 在一个方面，本发明涉及一种治疗血液癌症（例如多发性骨髓瘤，白血病，淋巴瘤）的方法，包括向有需要的患者施用治疗有效量的组蛋白脱乙酰酶抑制剂，例如组蛋白脱乙酰酶 （HDAC）抑制剂，例如PXD-101。 在另一方面，本发明涉及一种治疗癌症的方法（例如，实体肿瘤癌症，例如直肠癌，结肠癌，卵巢癌;血液癌症，例如多发性骨髓瘤，白血病，淋巴瘤），其包括向患者施用 需要第一量的组蛋白脱乙酰酶（HDAC）抑制剂，例如本文所述的组蛋白脱乙酰酶抑制剂，例如PXD-101，和第二量的其它化学治疗剂，例如其它化学治疗剂 选自：针对VEGF的抗体，Avastin，针对CD20的抗体，利妥昔单抗，硼替佐米，沙利度胺，地塞米松，长春新碱，多柔比星和美法仑，其中第一和第二量一起包含治疗有效量。
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公开(公告)号：US20060044803A1
公开(公告)日：2006-03-02
申请号：US11181674
申请日：2005-07-14
Applicant: Nicholas Edwards
Inventor： Nicholas Edwards
IPC: F21V29/00
CPC classification number: H01L25/0753 , F21K9/00 , F21V29/89 , H01L2224/48091 , H01L2924/00014
Abstract: An LED light source including a plurality of LED dies, a corresponding number of heat sinks each having an integral light reflector on which a die is mounted, and a dielectric substrate on one side of which the heat sinks are contiguously mounted in spaced apart relationship with the light reflector remote the dielectric substrate. The heat sinks each include an island of material having high thermal conductivity and of sufficient thickness to ensure that heat generated in the die is distributed substantially uniformly over a contact region between the substrate and the heat sink.
Abstract translation: 包括多个LED管芯的LED光源，相应数量的散热器，每个散热器具有安装有管芯的一体的光反射器;以及电介质基板，其一侧的散热器以相互间隔开的关系连续地安装 光反射器远离电介质基板。 散热器各自包括具有高导热性和足够厚度的材料岛，以确保在模具中产生的热量基本均匀地分布在基板和散热器之间的接触区域上。
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3.发明授权Cheese package, film, bag and process for packaging a CO2 respiring foodstuff 失效奶酪包装，薄膜，袋子和包装二氧化碳呼吸食品的工艺公开(公告)号：US06316067B1
公开(公告)日：2001-11-13
申请号：US08191886
申请日：1994-02-03
Applicant: David Nicholas Edwards , Stephen James Vicik
Inventor： David Nicholas Edwards , Stephen James Vicik
IPC: B32B2732
CPC classification number: B32B27/08 , B32B7/12 , B32B2307/31 , B32B2307/518 , B32B2307/7244 , B32B2307/736 , Y10S428/91 , Y10T428/1328 , Y10T428/1383 , Y10T428/2495 , Y10T428/263 , Y10T428/2826 , Y10T428/31743 , Y10T428/3175 , Y10T428/31913 , Y10T428/3192
Abstract: A packaged article, especially a respiring foodstuff such as cheese which generates or releases gas during storage, and a permeable multilayer biaxially oriented film suitable for allowing escape of such gas while minimizing transfer of oxygen across the film which has a thin layer of a blend of EVOH and nylon. In a preferred embodiment the low cost film having a high permeability to CO2 and low O2 permeability is used to package cheese.
Abstract translation: 包装制品，特别是在储存期间产生或释放气体的呼吸性食品如奶酪，以及可渗透的多层双轴取向膜，其适于允许这种气体逸出，同时最小化氧穿过膜的转移，所述薄膜具有薄层的混合物 EVOH和尼龙。 在优选的实施方案中，使用具有高的二氧化碳渗透性和低的O 2渗透性的低成本薄膜来包装干酪。
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公开(公告)号：US20070192619A1
公开(公告)日：2007-08-16
申请号：US10592757
申请日：2005-03-21
Applicant: Maurice Gifford , Nicholas Edwards , Paul Kearney
Inventor： Maurice Gifford , Nicholas Edwards , Paul Kearney
IPC: H04L9/00
CPC classification number: G06F21/34 , G06F21/32 , G06F2221/2113 , G06F2221/2137 , G06Q20/4014
Abstract: An identity confirmation device comprises a token issuer 4 and an authentication device 5, the token issuer being programmable by a central identity provider 2 to issue certification tokens for use in e-commerce whereby transactions can be certified with suppliers without need for additional communication with a central server.
Abstract translation: 身份确认设备包括令牌发行者4和认证设备5，令牌发行者可由中央身份提供商2编程，以发行用于电子商务的认证令牌，其中交易可以被供应商认证，而不需要与 中央服务器。
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Patent Agency Ranking
5.发明授权Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent 有权组蛋白脱乙酰酶（HDAC）抑制剂（PXD101）用于单独治疗癌症或与化学治疗剂组合公开(公告)号：US08828392B2
公开(公告)日：2014-09-09
申请号：US12093069
申请日：2006-11-10
Applicant: Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
Inventor： Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
IPC: A61K39/395 , A01N37/28 , C12N5/02 , C12N5/0781 , C12N5/09 , A61K31/10 , A61K31/65 , A61K31/573 , A61K31/475 , A61K45/06 , A61K31/196
CPC classification number: A61K31/475 , A61K31/10 , A61K31/185 , A61K31/196 , A61K31/573 , A61K31/65 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K2300/00
Abstract: The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological cancer (e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof a therapeutically effective amount of a histone deacetylase inhibitor, for example, a histone deacetylase (HDAC) inhibitor as described herein, for example, PXD-101. In another respect, the present invention relates to a method of treating cancer (e.g., solid tumor cancer, e.g., rectal cancer, colon cancer, ovarian cancer; hematological cancer, e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof, a first amount of a histone deacetylase (HDAC) inhibitor, for example, a histone deacetylase inhibitor as described herein, for example, PXD-101, and a second amount of an other chemotherapeutic agent, for example, an other chemotherapeutic agent selected from: an antibody against VEGF, AVASTIN® (bevacizumab), an antibody against CD20, rituximab, bortezomib, thalidomide, dexamethasone, vincristine, doxorubicin, and melphalan, wherein the first and second amounts together comprise a therapeutically effective amount.
Abstract translation: 本发明一般涉及治疗癌症的方法。 在一个方面，本发明涉及一种治疗血液癌症（例如多发性骨髓瘤，白血病，淋巴瘤）的方法，包括向有需要的患者施用治疗有效量的组蛋白脱乙酰酶抑制剂，例如组蛋白脱乙酰酶 （HDAC）抑制剂，例如PXD-101。 在另一方面，本发明涉及一种治疗癌症的方法（例如，实体肿瘤癌症，例如直肠癌，结肠癌，卵巢癌;血液癌症，例如多发性骨髓瘤，白血病，淋巴瘤），其包括向患者施用 需要第一量的组蛋白脱乙酰酶（HDAC）抑制剂，例如本文所述的组蛋白脱乙酰酶抑制剂，例如PXD-101，和第二量的其它化学治疗剂，例如其它化学治疗剂 选自：抗VEGF抗体（贝伐单抗），抗CD20抗体，利妥昔单抗，硼替佐米，沙利度胺，地塞米松，长春新碱，多柔比星和美法仑，其中第一和第二量一起包含治疗有效量。
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公开(公告)号：US20090161206A1
公开(公告)日：2009-06-25
申请号：US12295880
申请日：2007-06-01
Applicant: Nicholas Edwards
Inventor： Nicholas Edwards
CPC classification number: G02B21/16 , G02B6/4298 , Y10S362/80
Abstract: A point electromagnetic radiation source apparatus (200) for fluorescence microscopy comprises an array of individually unpackaged light emitting diodes. A lightguide (102) is coupled to the array of individually unpackaged light emitting diodes (202) by abutment, the lightguide having a coupling window (210) that receives electromagnetic radiation emitted by the array of individually unpackaged 10 light emitting diodes (202).
Abstract translation: 用于荧光显微镜的点电磁辐射源装置（200）包括单独未封装的发光二极管的阵列。 光导（102）通过邻接耦合到单独未封装的发光二极管（202）的阵列，光导具有耦合窗口（210），其接收由单独未封装的10个发光二极管（202）的阵列发射的电磁辐射。
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公开(公告)号：US20050165674A1
公开(公告)日：2005-07-28
申请号：US10507824
申请日：2003-03-18
Applicant: Nicholas Edwards , James Chapman , Maurice Gifford
Inventor： Nicholas Edwards , James Chapman , Maurice Gifford
Abstract: In a transaction authorisation arrangement a sales point (1) (an electronic point of sale device or a vending machine, for example) communicates with a transaction application (2) transmitting thereto a transaction value. The telephony platform (3) reserves one of a series of premium rate numbers (5) which can be dialled up by a mobile telephone user to authorise the charging of the transaction against the telephone bill. When a call is received at the premium rate number the telephony platform notifies the transaction application which then authorises the sale.
Abstract translation: 在交易授权安排中，销售点（1）（例如，电子销售点设备或自动售货机）与向其传送交易值的交易应用程序（2）进行通信。 电话平台（3）保留了一系列附加费率数字（5），可由移动电话用户拨打电话号码，以授权对电话费用进行交易。 当按照保费率号码接收到呼叫时，电话平台通知交易应用程序，然后授权销售。
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公开(公告)号：US06511688B2
公开(公告)日：2003-01-28
申请号：US09950471
申请日：2001-09-10
Applicant: David Nicholas Edwards , Stephen James Vicik
Inventor： David Nicholas Edwards , Stephen James Vicik
IPC: A23C1916
CPC classification number: B32B7/12 , B32B1/08 , B32B27/08 , B32B2270/00 , B32B2307/31 , B32B2329/00 , B32B2377/00 , B32B2439/70 , Y10T428/1341 , Y10T428/31743 , Y10T428/31746 , Y10T428/31928 , Y10T428/31949
Abstract: A packaged article, especially a respiring foodstuff such as cheese which generates or releases gas during storage, and a permeable multilayer biaxially oriented film suitable for allowing escape of such gas while minimizing transfer of oxygen across the film which has a thin layer of a blend of EVOH and nylon. In a preferred embodiment the low cost film having a high permeability to CO2 and low O2 permeability is used to package cheese.
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公开(公告)号：US07862218B2
公开(公告)日：2011-01-04
申请号：US12295880
申请日：2007-06-01
Applicant: Nicholas Edwards
Inventor： Nicholas Edwards
IPC: F21V33/00
CPC classification number: G02B21/16 , G02B6/4298 , Y10S362/80
Abstract: A point electromagnetic radiation source apparatus (200) for fluorescence microscopy comprises an array of individually unpackaged light emitting diodes. A lightguide (102) is coupled to the array of individually unpackaged light emitting diodes (202) by abutment, the lightguide having a coupling window (210) that receives electromagnetic radiation emitted by the array of individually unpackaged 10 light emitting diodes (202).
Abstract translation: 用于荧光显微镜的点电磁辐射源装置（200）包括单独未封装的发光二极管的阵列。 光导（102）通过邻接耦合到单独未封装的发光二极管（202）的阵列，光导具有耦合窗口（210），其接收由单独未封装的10个发光二极管（202）的阵列发射的电磁辐射。
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