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1.发明授权N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof 有权N-环丙基-N-哌啶基 - 酰胺衍生物，药物组合物及其用途公开(公告)号：US08921398B2
公开(公告)日：2014-12-30
申请号：US13489557
申请日：2012-06-06
申请人： Armin Heckel , Frank Himmelsbach , Elke Langkopf , Bernd Nosse , Neil J. Ashweek , Nicole Harriott
发明人： Armin Heckel , Frank Himmelsbach , Elke Langkopf , Bernd Nosse , Neil J. Ashweek , Nicole Harriott
IPC分类号： C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , A61K31/4468 , A61K31/497 , C07D401/12 , C07D401/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to compounds of general formula I, wherein R1, LP, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式Ⅰ化合物，其中R1，LP，HetAr，Ar和n如申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
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公开(公告)号：US08822471B2
公开(公告)日：2014-09-02
申请号：US13418376
申请日：2012-03-13
申请人： Bernd Nosse , Andreas Blum , Steffen Breitfelder , Armin Heckel , Frank Himmelsbach , Elke Langkopf , Bernd Wellenzohn , Neil J. Ashweek , Nicole Harriott
发明人： Bernd Nosse , Andreas Blum , Steffen Breitfelder , Armin Heckel , Frank Himmelsbach , Elke Langkopf , Bernd Wellenzohn , Neil J. Ashweek , Nicole Harriott
IPC分类号： A61K31/4545 , A61K31/506 , A61K31/501 , C07D413/14 , C07D413/04 , C07D417/14
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，LP，LQ，Ar，m和n基团如本申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性 。
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3.发明申请N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF 审中-公开N-环丙基-N-哌啶基酰胺，含有它们的药物组合物及其用途公开(公告)号：US20140045823A1
公开(公告)日：2014-02-13
申请号：US13955170
申请日：2013-07-31
申请人： Bernd NOSSE , Matthias ECKHARDT , Frank HIMMELSBACH , Elke LANGKOPF , Neil J. ASHWEEK , Nicole HARRIOTT
发明人： Bernd NOSSE , Matthias ECKHARDT , Frank HIMMELSBACH , Elke LANGKOPF , Neil J. ASHWEEK , Nicole HARRIOTT
IPC分类号： C07D401/12 , C07D413/14 , C07D413/12 , A61K45/06 , A61K31/497 , A61K31/454 , A61K31/506 , A61K31/553 , C07D401/14 , A61K31/4545
CPC分类号： C07D417/14 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/553 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to compounds of general formula I, wherein R1, LP, HetAr1, (Het)Ar2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，LP，HetAr1，（Het）Ar2和n如本申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
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4.发明申请N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF 有权N-环丙基-N-哌啶基酰胺衍生物，含有它们的药物组合物及其用途公开(公告)号：US20140031369A1
公开(公告)日：2014-01-30
申请号：US13947200
申请日：2013-07-22
IPC分类号： C07D413/12 , A61K45/06 , A61K31/506 , C07D401/14 , A61K31/4545 , A61K31/497 , A61K31/454 , C07D401/12
CPC分类号： C07D413/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14
摘要： The present invention relates to compounds of general formula I, wherein R1, LP, (Het)Ar1, (Het)Ar2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，LP，（Het）Ar1，（Het）Ar2和n如本申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节 其活动。
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公开(公告)号：US08293729B2
公开(公告)日：2012-10-23
申请号：US12821231
申请日：2010-06-23
申请人： Brian Dyck , Joe A. Tran , Junko Tamiya , Florence Jovic , Troy Vickers , Chen Chen , Nicole Harriott , Timothy Coon , Neil J. Ashweek
发明人： Brian Dyck , Joe A. Tran , Junko Tamiya , Florence Jovic , Troy Vickers , Chen Chen , Nicole Harriott , Timothy Coon , Neil J. Ashweek
IPC分类号： C07D211/68 , C07D401/10 , C07D413/14 , A61K31/15
CPC分类号： C07D211/72 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
摘要： New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein R1, R2, R3, n, p, q, and Ar are as defined herein, including stereoisomers, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising a compound of this invention, as well as methods relating to the use thereof in a patient in need thereof.
摘要翻译： 公开了可用于治疗患者中各种代谢相关病症的新化合物。 本发明的化合物具有结构（I）：其中R1，R2，R3，n，p，q和Ar如本文所定义，包括立体异构体及其药学上可接受的盐。 还公开了包含本发明化合物的药物组合物以及与其在有需要的患者中的用途有关的方法。
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6.发明授权N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions containing them and uses thereof 有权N-环丙基-N-哌啶基 - 酰胺衍生物，含有它们的药物组合物及其用途公开(公告)号：US08927726B2
公开(公告)日：2015-01-06
申请号：US13947200
申请日：2013-07-22
IPC分类号： A61K31/445 , C07D401/00 , C07D413/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14
CPC分类号： C07D413/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14
摘要： The present invention relates to compounds of general formula I, wherein R1, LP, (Het)Ar1, (Het)Ar2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，LP，（Het）Ar1，（Het）Ar2和n如本申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节 其活动。
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公开(公告)号：US20130143892A1
公开(公告)日：2013-06-06
申请号：US13489557
申请日：2012-06-06
申请人： Armin HECKEL , Frank HIMMELSBACH , Elke LANGKOPF , Bernd NOSSE , Neil J. ASHWEEK , Nicole HARRIOTT
发明人： Armin HECKEL , Frank HIMMELSBACH , Elke LANGKOPF , Bernd NOSSE , Neil J. ASHWEEK , Nicole HARRIOTT
IPC分类号： C07D413/14 , C07D403/12 , C07D413/12 , C07D403/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to compounds of general formula I, wherein R1, LP, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式Ⅰ化合物，其中R1，LP，HetAr，Ar和n如申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
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公开(公告)号：US20130065906A1
公开(公告)日：2013-03-14
申请号：US13418376
申请日：2012-03-13
申请人： Bernd NOSSE , Andreas BLUM , Steffen BREITFELDER , Armin HECKEL , Frank HIMMELSBACH , Elke LANGKOPF , Bernd WELLENZOHN , Neil J. ASHWEEK , Nicole HARRIOTT
发明人： Bernd NOSSE , Andreas BLUM , Steffen BREITFELDER , Armin HECKEL , Frank HIMMELSBACH , Elke LANGKOPF , Bernd WELLENZOHN , Neil J. ASHWEEK , Nicole HARRIOTT
IPC分类号： C07D413/14 , A61K31/4545 , C07D417/14 , A61K31/506 , A61P3/06 , A61K31/497 , A61K31/501 , C07D401/14 , A61P3/10 , A61P3/04 , A61K31/454 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，LP，LQ，Ar，m和n基团如本申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性 。
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公开(公告)号：US20110166116A1
公开(公告)日：2011-07-07
申请号：US12821231
申请日：2010-06-23
申请人： Brian DYCK , Joe A. TRAN , Junko TAMIYA , Florence JOVIC , Troy VICKERS , Chen CHEN , Nicole HARRIOTT , Timothy COON , Neil J. ASHWEEK
发明人： Brian DYCK , Joe A. TRAN , Junko TAMIYA , Florence JOVIC , Troy VICKERS , Chen CHEN , Nicole HARRIOTT , Timothy COON , Neil J. ASHWEEK
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D403/14 , A61K31/497 , C07D495/04 , A61K31/519 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D471/02 , A61K31/437 , A61K31/496 , C07D243/08 , A61K31/551 , A61P3/10
CPC分类号： C07D211/72 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
摘要： New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein R1, R2, R3, n, p, q, and Ar are as defined herein, including stereoisomers, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising a compound of this invention, as well as methods relating to the use thereof in a patient in need thereof.
摘要翻译： 公开了可用于治疗患者中各种代谢相关病症的新化合物。 本发明的化合物具有结构（I）：其中R1，R2，R3，n，p，q和Ar如本文所定义，包括立体异构体及其药学上可接受的盐。 还公开了包含本发明化合物的药物组合物以及与其在有需要的患者中的用途有关的方法。
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