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公开(公告)号：US08200674B2
公开(公告)日：2012-06-12
申请号：US12356046
申请日：2009-01-19
IPC分类号： G06F17/30
CPC分类号： G06F17/30766 , G06F17/30749
摘要： Systems and methods for personalized media recommendation are provided. One example system may include a media server including a media database containing a plurality of media tracks and a database schema defining multiple media styles. The media server may further include a media delivery engine configured to transmit media tracks to each of a plurality of media clients. The system may further include a feedback module configured to receive history data from each of the media clients. Further still, the system may include a recommendation engine configured to compute a plurality of user-specific style weights, and to select one or more recommended media tracks for each user, The recommendation engine may be further configured to send a recommendation message to the media client including media links to the recommended media tracks on the media server, to cause the media client to display the media links to a user.
摘要翻译： 提供个性化媒体推荐的系统和方法。 一个示例性系统可以包括媒体服务器，该媒体服务器包括媒体数据库，该媒体数据库包含多个媒体轨道和定义多种媒体风格的数据 媒体服务器还可以包括被配置为向多个媒体客户端中的每一个发送媒体轨道的媒体传送引擎。 该系统可以进一步包括被配置为从每个媒体客户端接收历史数据的反馈模块。 此外，系统还可以包括被配置为计算多个用户特定样式权重的推荐引擎，并且为每个用户选择一个或多个推荐的媒体轨道。推荐引擎还可以被配置为向媒体发送推荐消息 客户端包括媒体链接到媒体服务器上的推荐媒体轨道，以使媒体客户端显示到用户的媒体链接。
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公开(公告)号：US06969614B1
公开(公告)日：2005-11-29
申请号：US09913667
申请日：2000-02-16
CPC分类号： G01N33/6803 , G01N2001/284 , Y10T436/25375 , Y10T436/255
摘要： The present invention describes devices and methods for performing protein analysis on laser capture microdissected cells, which permits proteomic analysis on cells of different populations. Particular disclosed examples are analysis of normal versus malignant cells, or a comparison of differential protein expression in cells that are progressing from normal to malignant. The protein content of the microdissected cells may be analyzed using techniques such as immunoassays, 1D and 2D gel electrophoresis characterization, Western blotting, liquid chromatography quadrapole ion trap electrospray (LCQ-MS), Matrix Assisted Laser Desorption Ionization/Time of Flight (MALDI/TOF), and Surface Enhanced Laser Desorption Ionization Spectroscopy (SELDI). In addition to permitting direct comparison of qualitative and quantitative protein content of tumor cells and normal cells from the same tissue sample, the methods also allow for investigation of protein characteristics of tumor cells, such as binding ability and amino acid sequence, and differential expression of proteins in particular cell populations in response to drug treatment. The present methods also provide, through the use of protein fingerprinting, a rapid and reliable way to identify the source tissue of a tumor metastasis.
摘要翻译： 本发明描述了用于对激光捕获显微切割细胞进行蛋白质分析的装置和方法，其允许对不同群体的细胞进行蛋白质组学分析。 特别公开的实例是正常与恶性细胞的分析，或从正常到恶性进展的细胞中差异蛋白表达的比较。 可以使用免疫测定，1D和2D凝胶电泳表征，Western印迹，液相色谱四极离子阱电喷雾（LCQ-MS），基质辅助激光解吸电离/飞行时间（MALDI / TOF）和表面增强激光解吸电离光谱（SELDI）。 除了允许直接比较来自相同组织样品的肿瘤细胞和正常细胞的定性和定量蛋白质含量之外，该方法还允许研究肿瘤细胞的蛋白质特征，例如结合能力和氨基酸序列，以及差异表达 蛋白质在特定的细胞群体响应药物治疗。 本方法还通过使用蛋白质指纹图谱提供了一种快速可靠的方法来鉴定肿瘤转移的源组织。
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公开(公告)号：US20100185671A1
公开(公告)日：2010-07-22
申请号：US12356046
申请日：2009-01-19
IPC分类号： G06F17/30
CPC分类号： G06F17/30766 , G06F17/30749
摘要： Systems and methods for personalized media recommendation are provided. One example system may include a media server including a media database containing a plurality of media tracks and a database schema defining multiple media styles. The media server may further include a media delivery engine configured to transmit media tracks to each of a plurality of media clients. The system may further include a feedback module configured to receive history data from each of the media clients. Further still, the system may include a recommendation engine configured to compute a plurality of user-specific style weights, and to select one or more recommended media tracks for each user, The recommendation engine may be further configured to send a recommendation message to the media client including media links to the recommended media tracks on the media server, to cause the media client to display the media links to a user.
摘要翻译： 提供个性化媒体推荐的系统和方法。 一个示例性系统可以包括媒体服务器，该媒体服务器包括媒体数据库，该媒体数据库包含多个媒体轨道和定义多种媒体风格的 媒体服务器还可以包括被配置为向多个媒体客户端中的每一个发送媒体轨道的媒体传送引擎。 该系统可以进一步包括被配置为从每个媒体客户端接收历史数据的反馈模块。 此外，系统还可以包括被配置为计算多个用户特定样式权重的推荐引擎，并且为每个用户选择一个或多个推荐的媒体轨道。推荐引擎还可以被配置为向媒体发送推荐消息 客户端包括媒体链接到媒体服务器上的推荐媒体轨道，以使媒体客户端显示到用户的媒体链接。
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