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1.发明授权Identification of drug candidates modulating factor VII-mediated intracellular signaling 失效鉴定药物候选物调节因子VII介导的细胞内信号传导公开(公告)号：US06268163B1
公开(公告)日：2001-07-31
申请号：US09116748
申请日：1998-07-16
IPC分类号： C12Q148
CPC分类号： G01N33/5008 , A61K38/4846 , G01N33/5011 , G01N33/5035 , G01N33/5041 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： The present invention provides methods for identifying candidate drugs that modulate factor VIIa-mediated intracellular signaling by measuring the effects of such drugs on the activation of the mitogen-activated protein kinase (MAP kinase) signaling pathway.
摘要翻译： 本发明提供了通过测量这些药物对丝裂原活化蛋白激酶（MAP激酶）信号通路的激活的影响来鉴定调节因子VIIa介导的细胞内信号传导的候选药物的方法。
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公开(公告)号：US20070232542A1
公开(公告)日：2007-10-04
申请号：US11755470
申请日：2007-05-30
申请人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
IPC分类号： A61K38/36
CPC分类号： G01N33/5041 , A61K38/36 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
摘要翻译： 描述了表达组织因子（TF）的细胞中凝血因子VII（FVII）的新型细胞内信号传导活性。 本发明涉及FVIIa或另一种TF激动剂或FVIIa或另一种TF拮抗剂在制备用于调节FVIIa诱导的患者中MAPK信号通路的激活的药物中的用途。 此外，本发明涉及一种治疗方法和检测与FVIIa介导的细胞内信号传导途径相互作用的化合物，特别是候选药物的活性的方法。
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3.发明申请公开(公告)号：US20050245449A1
公开(公告)日：2005-11-03
申请号：US11175639
申请日：2005-07-06
申请人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
CPC分类号： G01N33/5041 , A61K38/36 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
摘要翻译： 描述了表达组织因子（TF）的细胞中凝血因子VII（FVII）的新型细胞内信号传导活性。 本发明涉及FVIIa或另一种TF激动剂或FVIIa或另一种TF拮抗剂在制备用于调节FVIIa诱导的患者中MAPK信号通路的激活的药物中的用途。 此外，本发明涉及一种治疗方法和检测与FVIIa介导的细胞内信号传导途径相互作用的化合物，特别是候选药物的活性的方法。
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4.发明授权Methods for modifying cell motility using factor VIIa or inactivated factor VIIa 有权使用因子VIIa或灭活因子Ⅶa修饰细胞运动的方法公开(公告)号：US06461610B1
公开(公告)日：2002-10-08
申请号：US09372888
申请日：1999-08-12
申请人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
IPC分类号： A61K3848
CPC分类号： G01N33/5041 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5035 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： The present invention provides methods for modifying the motility of tissue factor (TF)-expressing cells, which are carried out by contacting such cells with an effective amount of Factor VIIai Factor VIIa agonist.
摘要翻译： 本发明提供了通过使这些细胞与有效量的因子VIIai因子VIIa激动剂接触而进行的改变组织因子（TF）表达细胞运动性的方法。
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