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公开(公告)号：US20090181950A1
公开(公告)日：2009-07-16
申请号：US12300832
申请日：2007-05-17
IPC分类号： A61K31/55 , C07D401/14 , A61P29/00 , A61P37/08
CPC分类号： C07D215/54 , C07D215/48
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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公开(公告)号：US20080207638A1
公开(公告)日：2008-08-28
申请号：US11995927
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotis Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： A61K31/4965 , C07D241/02 , A61P11/00
CPC分类号： C07D403/12
摘要： The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物及其盐，其制备方法，含有它们的组合物及其在治疗各种疾病如过敏性鼻炎中的用途。
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3.发明申请Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists 审中-公开可用作组胺H3受体拮抗剂和/或反激动剂的哌嗪酮衍生物公开(公告)号：US20080275027A1
公开(公告)日：2008-11-06
申请号：US11995929
申请日：2006-07-17
申请人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotic Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
发明人： Rachael Ann Ancliff , Mark James Bamford , Simon Teanby Hodgson , Christopher Allan Parr , Panayiotic Alexandrou Procopiou , David Matthew Wilson , Michael Woodrow
IPC分类号： C07D241/08 , A61K31/497 , C07D401/12 , A61P37/00 , A61P37/08 , A61K31/55 , C07D403/12
CPC分类号： C07D487/04 , C07D241/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D409/14 , C07D413/10 , C07D417/14
摘要： The invention relates to compounds of formula (I) or salts and solvates thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis: wherein R1 and R2 are as defined in the specification.
摘要翻译： 本发明涉及式（I）化合物或其盐和溶剂合物，其制备方法，含有它们的组合物及其在治疗各种疾病如抗过敏性鼻炎中的用途：其中R 1〜 >和R 2-2如说明书中所定义。
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4.发明授权Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases 有权用于治疗炎性疾病的吗啉基 - 脲衍生物公开(公告)号：US07622464B2
公开(公告)日：2009-11-24
申请号：US10509162
申请日：2003-03-27
申请人： Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
发明人： Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
IPC分类号： A61K31/535 , C07D413/14 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
摘要翻译： 式（I）化合物：其中：R 1表示取代或未取代的杂芳基; Y表示 - （CRnaRnb）n-; Rna和Rnb各自独立地为氢或C 1-6烷基; n为0〜5的整数， R2表示未取代或取代的芳基或未取代或取代的杂芳基; R3和R4各自独立地表示氢或C1-6烷基; R 7表示氢或C 1-6烷基; R8代表氢或C1-6烷基; 其盐和溶剂合物; 是CCR3拮抗剂，因此被认为可用于治疗。
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