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公开(公告)号:US09649314B2
公开(公告)日:2017-05-16
申请号:US14652102
申请日:2013-12-12
IPC分类号: A61K31/519 , C07D471/14 , C07D471/04
CPC分类号: A61K31/519 , C07D471/04 , C07D471/14
摘要: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US07045504B2
公开(公告)日:2006-05-16
申请号:US11018311
申请日:2004-12-22
IPC分类号: A61K38/00
CPC分类号: C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要: The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
摘要翻译: 本发明涉及作为尿激酶结合尿激酶受体的抑制剂的环肽。 所述环肽适合作为尿激酶及其受体介导的病症的药物活性物质。
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公开(公告)号:US20170197959A1
公开(公告)日:2017-07-13
申请号:US15315579
申请日:2015-06-02
IPC分类号: C07D471/04 , A61K31/519 , C07D495/14
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06 , C07D495/14 , A61K2300/00
摘要: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US20170183341A1
公开(公告)日:2017-06-29
申请号:US15315582
申请日:2015-06-02
IPC分类号: C07D471/04 , A61K31/519
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06
摘要: The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号:US20100261758A1
公开(公告)日:2010-10-14
申请号:US12294790
申请日:2007-03-28
IPC分类号: A61K31/444 , C07D211/82 , C07D213/02 , C07D215/04 , C07D513/04 , C07D233/54 , C07D231/12 , C07D401/02 , A61K31/435 , A61K31/47 , A61K31/426 , A61K31/415 , A61K31/4439 , A61P3/10 , A61P9/00 , A61P3/04
CPC分类号: C07D213/81 , C07D213/89 , C07D215/50 , C07D233/90 , C07D237/24 , C07D261/18 , C07D401/12 , C07D413/12 , C07D513/04
摘要: Compounds of Formula (I) wherein R1 is aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R2 is defined heterocyclyl, R3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R4 is H or alkyl, or R3 and R4 together with the carbon atom to which they are attached are cycloalkyl fused with aryl, and their use as pharmaceuticals.
摘要翻译: 式(I)的化合物,其中R 1是芳基,环己基或杂环基,或被芳基,环己基或杂环基取代的(C 1-4)烷基,R 2是限定性杂环基,R 3是烷基,芳基,环己基或杂环基,或 )烷基取代的芳基,环己基或杂环基,R 4为H或烷基,或者R 3和R 4与它们所连接的碳原子一起为与芳基稠合的环烷基,以及它们作为药物的用途。
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公开(公告)号:US20060105943A1
公开(公告)日:2006-05-18
申请号:US11321534
申请日:2005-12-30
IPC分类号: A61K38/12
CPC分类号: C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要: The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
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公开(公告)号:US06906032B1
公开(公告)日:2005-06-14
申请号:US10031401
申请日:2000-07-19
申请人: Olaf Wilhelm , Horst Kessler , Markus Bürgle , Nils Potthoff , Niko Schmiedeberg
发明人: Olaf Wilhelm , Horst Kessler , Markus Bürgle , Nils Potthoff , Niko Schmiedeberg
CPC分类号: C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要: The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
摘要翻译: 本发明涉及作为尿激酶结合尿激酶受体的抑制剂的环肽。 所述环肽适合作为尿激酶及其受体介导的病症的药物活性物质。
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公开(公告)号:US20150344476A1
公开(公告)日:2015-12-03
申请号:US14728613
申请日:2015-06-02
IPC分类号: C07D471/14 , C07D495/14 , A61K31/4745 , C07D471/16 , A61K31/444 , A61K31/4375 , C07D471/04
CPC分类号: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4745 , A61K45/06 , C07D471/14 , C07D471/16 , C07D495/14 , A61K2300/00
摘要: The invention relates to compound of the formula (I′) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译: 本发明涉及式(I')化合物或其盐,其中取代基如说明书中所定义; 作为其制备,用作药物和包含它的药物。
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公开(公告)号:US20050101526A1
公开(公告)日:2005-05-12
申请号:US11018311
申请日:2004-12-22
申请人: Olaf Wilhelm , Horst Kessler , Markus Burgle , Nils Potthoff , Niko Schmiedeberg
发明人: Olaf Wilhelm , Horst Kessler , Markus Burgle , Nils Potthoff , Niko Schmiedeberg
CPC分类号: C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要: The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
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公开(公告)号:US20150335646A1
公开(公告)日:2015-11-26
申请号:US14652102
申请日:2013-12-12
IPC分类号: A61K31/519 , C07D471/14 , C07D471/04
CPC分类号: A61K31/519 , C07D471/04 , C07D471/14
摘要: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译: 本发明涉及式(I)化合物; 或其盐,其中取代基如说明书中所定义; 作为其制备,用作药物和包含它的药物。
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