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公开(公告)号：US20100261758A1
公开(公告)日：2010-10-14
申请号：US12294790
申请日：2007-03-28
IPC分类号： A61K31/444 , C07D211/82 , C07D213/02 , C07D215/04 , C07D513/04 , C07D233/54 , C07D231/12 , C07D401/02 , A61K31/435 , A61K31/47 , A61K31/426 , A61K31/415 , A61K31/4439 , A61P3/10 , A61P9/00 , A61P3/04
CPC分类号： C07D213/81 , C07D213/89 , C07D215/50 , C07D233/90 , C07D237/24 , C07D261/18 , C07D401/12 , C07D413/12 , C07D513/04
摘要： Compounds of Formula (I) wherein R1 is aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R2 is defined heterocyclyl, R3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R4 is H or alkyl, or R3 and R4 together with the carbon atom to which they are attached are cycloalkyl fused with aryl, and their use as pharmaceuticals.
摘要翻译： 式（I）的化合物，其中R 1是芳基，环己基或杂环基，或被芳基，环己基或杂环基取代的（C 1-4）烷基，R 2是限定性杂环基，R 3是烷基，芳基，环己基或杂环基，或 ）烷基取代的芳基，环己基或杂环基，R 4为H或烷基，或者R 3和R 4与它们所连接的碳原子一起为与芳基稠合的环烷基，以及它们作为药物的用途。
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2.发明授权N-arylsulfonyl-2,3-dihydro-1H-indoles and the use thereof as CCR9 inhibitors 失效N-芳基磺酰基-2,3-二氢-1H-吲哚及其作为CCR9抑制剂的用途公开(公告)号：US07781481B2
公开(公告)日：2010-08-24
申请号：US12158369
申请日：2006-12-22
IPC分类号： A01N43/38
CPC分类号： C07D209/42
摘要： N-(benzenesulphonyl)-2,3-dihydro-1H-indols, wherein the indol is substituted by cyano, carboxy or alkylcarbonyloxy and their use as therapeutical agents.
摘要翻译： N-（苯磺酰基）-2,3-二氢-1H-吲哚，其中吲哚被氰基，羧基或烷基羰基氧基取代，并且作为治疗剂使用。
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公开(公告)号：US07759390B2
公开(公告)日：2010-07-20
申请号：US12158385
申请日：2006-12-22
IPC分类号： A61K31/38 , C07D333/32
CPC分类号： C07D333/34
摘要： Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1-4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.
摘要翻译： 式I化合物，其中R 1和R 2之一是被卤素取代的噻吩基，R 1和R 2中的另一个是取代的苯基，其中取代基如权利要求中所定义，条件是苯基被 至少一个氰基，羧基或（C 1-4）烷氧基羰基是CCR9活性的抑制剂，可用于治疗性治疗。
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公开(公告)号：US20080312313A1
公开(公告)日：2008-12-18
申请号：US12158386
申请日：2006-12-22
IPC分类号： A61K31/381 , C07D333/34 , A61K31/18 , C07C307/02
CPC分类号： C07D333/34 , C07C311/21
摘要： A compound of formula (I), wherein the residues have various meanings, useful as pharmaceuticals.
摘要翻译： 式（I）的化合物，其中残基具有各种含义，可用作药物。
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公开(公告)号：US20080300295A1
公开(公告)日：2008-12-04
申请号：US12158385
申请日：2006-12-22
IPC分类号： A61K31/381 , C07D333/34 , A61P1/00
CPC分类号： C07D333/34
摘要： Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1-4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.
摘要翻译： 式I化合物，其中R 1和R 2之一是被卤素取代的噻吩基，R 1和R 2中的另一个是取代的苯基，其中取代基如权利要求中所定义，条件是苯基被 至少一个氰基，羧基或（C 1-4）烷氧基羰基是CCR9活性的抑制剂，可用于治疗性治疗。
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公开(公告)号：US20080275114A1
公开(公告)日：2008-11-06
申请号：US12158358
申请日：2006-12-22
IPC分类号： C07C307/02 , C07C255/32 , A61K31/277 , A61K31/195 , A61P1/00
CPC分类号： C07C311/21 , C07C311/29 , C07C2601/14 , C07C2603/74
摘要： Compounds of formula (I), in which R1 and R2 are independently a substituted phenyl group, where the substituents are as defined in the claims and with the proviso that at least one of the substituents is a cyano, carboxy or (C1-4)alkoxycarbonyl group, are inhibitors of CCR9 activity useful for therapeutic treatment, particularly of irritable bowel disease.
摘要翻译： 式（I）的化合物，其中R 1和R 2各自独立地是取代的苯基，其中取代基如权利要求中所定义，条件是在 至少一个取代基是氰基，羧基或（C 1-4 - 烷氧基羰基）是可用于治疗性治疗，特别是肠易激惹病的CCR9活性的抑制剂。
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公开(公告)号：US20080269312A1
公开(公告)日：2008-10-30
申请号：US12158369
申请日：2006-12-12
IPC分类号： A61K31/404 , C07D209/12
CPC分类号： C07D209/42
摘要： N-(benzenesulphonyl)-2,3-dihydro-1H-indols, wherein the indol is substituted by cyano, carboxy or alkylcarbonyloxy and their use as therapeutical agents.
摘要翻译： N-（苯磺酰基）-2,3-二氢-1H-吲哚，其中吲哚被氰基，羧基或烷基羰基氧基取代，并且作为治疗剂使用。
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公开(公告)号：US20050163768A1
公开(公告)日：2005-07-28
申请号：US11088361
申请日：2005-03-23
申请人： Helmut Eckert , Herbert Jaksche , Evelyne Janzek , Hans Loibner , Dieter Scholz
发明人： Helmut Eckert , Herbert Jaksche , Evelyne Janzek , Hans Loibner , Dieter Scholz
IPC分类号： A61K39/00 , C07K16/10 , C07K16/30 , C07K16/42 , G01N33/569 , G01N33/574 , A61K39/395
CPC分类号： G01N33/56988 , A61K39/00 , C07K16/10 , C07K16/3023 , C07K16/3053 , C07K16/42 , C07K16/4266 , C07K2317/732 , C07K2317/734 , G01N33/56972 , G01N33/57423 , G01N33/57492
摘要： Monoclonal murine internal image anti-idiotypic antibodies (Ab2) to monoclonal antibodies BR55-2 (Ab1), process for the production thereof and use for prophylactic and/or therapeutic immunization against HIV-infections, against cancer of epithelial origin and against small cell lung cancer.
摘要翻译： 针对单克隆抗体BR55-2（Ab1）的单克隆鼠内部图像抗独特型抗体（Ab2），其生产方法和用于预防和/或治疗HIV感染的免疫，针对上皮起源癌和小细胞肺 癌症。
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