摘要:
The present invention relates to a liquid pharmaceutical preparation and a method for administering the pharmaceutical preparation by nebulization or soft mist inhalation. The pharmaceutical formulation comprises: (a) remdesivir or a pharmaceutically acceptable salt thereof; (b) an excipient selected from the group consisting of (i) a pharmacologically acceptable stabilizer or complexing agent and (ii) a solubility enhancing agent; and (c) a solvent wherein the pharmaceutical formulation has a pH of between about 2.0 and about 6.0.
摘要:
The present invention relates to formulations and method of drug administration useful for treating lung cancer (in particular, non-small lung cancer) by administering a therapeutic antibody drug with a soft mist inhaler or by nebulization.
摘要:
Systems and methods for testing a subject system with a software testing process are described. The system receives Boolean states responsive to repeatedly applying a first test case to a subject system. Each Boolean state signifies an outcome of an application of the first test case to a version of a first software feature over a span of time. The system identifies test case outcomes for the first test case that are adjacent in time and different and generates an intermittency value for the first test case. The system determines that the intermittency value for the first test case exceeds an intermittency threshold and alerts an engineering resource. Finally, the system repeats the above operations until the intermittency value for the first test case does not exceed the intermittency threshold.
摘要:
A base station herein assists a radio network controller (RNC) to allocate scrambling codes in a cell. The base station's assistance advantageously permits the RNC to allocate different length scrambling codes to different mobile terminals (or downlink carriers) in the cell. Specifically, the base station determines a preference for whether the length of a scrambling code to be allocated to each terminal or carrier should be short or long, based on whether uplink communications transmitted by the terminal, or downlink communications transmitted over the carrier, are to be processed with a high-complexity receiver or a low-complexity receiver. The RNC receives these preferences from the base station and takes them into account in order to allocate either a short scrambling code or a long scrambling code to each terminal or downlink carrier in the cell. The RNC then propagates the scrambling code allocations throughout the cell.
摘要:
According to the teachings presented herein, a method and apparatus for communication signal processing advantageously use a mix of parametric and non-parametric correlation estimation in communication signal processing. Non-parametric estimation generates an “overall” correlation estimate for a received communication signal, and parametric estimation generates a “component” correlation estimate. The component correlation estimate is removed from the overall correlation estimate to form a partial correlation estimate that is used to process the received communication signal at least initially, such as in a pre-equalization stage. The overall and component correlation estimates are generated as impairment and/or data correlation estimates.
摘要:
In a method of radio link handling in a radio base station (RBS) in a telecommunication system, said radio base station (RBS) supporting a plurality of mobile user equipment (UE) and comprising a plurality of antenna arrangements each associated with a respective determined cell coverage area. Performing the steps of actively determining (20) a respective local receive active set of cells or antennas for each of at least a subset of said plurality of mobile user equipment (UE). Finally, receiving and detecting (30) signals from each mobile user equipment (UE) jointly utilizing each said determined local receive active set.
摘要:
A method and apparatus for controlling the transmit power of a mobile device in a mobile communication network takes the level of self-interference into account to perform inner-loop power control. For normal inner-loop power control, a signal quality estimate is compared to a signal quality target and power control commands are generated based on the comparison. When self-interference is the dominant impairment in the received signal, a “fast break” is introduced to change inner-loop power control command generation.
摘要:
A base station (28) included in a radio access network of a telecommunications system has two diversity antennas (44A, 44B) for a cell/carrier utilized in a sector served by the base station which are respectively involved in transmission of two branches of a radio link signal of the cell/carrier between the base station and a user equipment unit (30). Two branches of signal processing hardware respectively process the two branches of the radio link signal to yield two respective processed branches of the radio link signal. A rake receiver (62, 262) measures the delay difference between the two processed branches of the radio link signal, and uses the measured delay difference for various purposes. For example, some embodiments of the invention use the delay difference between the two branches as measured by the rake receiver to compensate for a delay difference which exists between the two processed branches of the radio link signal. When measuring the delay difference between the two branches of an uplink radio signal, a rake receiver (62) at the radio base station is employed. On the other hand, when measuring the delay difference between the two branches of a downlink radio signal, a rake receiver (262) at test user equipment unit (30T) is employed.
摘要:
A system and method for detecting and selecting peaks in a delay power profile (DPP) signal. An adaptive threshold is used to determine valid paths in the DPP signal. The adaptive threshold is determined by measuring the signal-to-noise ratio of the DPP signal, and setting the threshold to minimize non-detections and false alarms in path estimation. To determine the signal-to-noise ratio, the system uses an iterative process wherein a raw estimate and an improved estimate are made of the noise.
摘要:
A water-injection foaming devolatilizing method includes the steps of: melting and kneading a polymer in a water-injection dispersing zone of an extruder having a screw; injecting water into a polymer melt so as to be dispersed into the polymer melt which is being kneaded; and vaporizing volatile components contained in the polymer melt together with water in a devolatilizing zone having a vent port and located on a downstream side of the water-injection dispersing zone, so that the volatile components are removed and discharged through the vent port. A pressure-reducing expansion zone is provided between the water-injection dispersing zone and the devolatilizing zone so as to be upstream of the vent port. The method further includes gradually reducing a pressure in the pressure-reducing expansion zone so that not only bubbles in the water which is dispersed into the polymer melt are made to grow up, but also the bubbles are broken down at a downstream end portion of the pressure-reducing expansion zone.