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Patent Agency Ranking
1.发明授权Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening 有权通过预测成熟的CDR爆破和队列文库生成和筛选，抗体超人性化公开(公告)号：US08716195B2
公开(公告)日：2014-05-06
申请号：US12085175
申请日：2006-11-10
Applicant: Guido Cappuccilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Ramesh R. Bhatt , Nurten Beyaz-Kavuncu
Inventor： Guido Cappuccilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Ramesh R. Bhatt , Nurten Beyaz-Kavuncu
IPC: C40B50/06
CPC classification number: C07K16/005 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/565 , C07K2317/622
Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
Abstract translation: 公开了针对改进的通用抗体文库的方法和组合物，其合理开发参考抗体文库（例如通用抗体文库）中所含的人类多样性信息。 所公开的方法涉及使用查询CDR序列来引导参与文库中存在的人抗体多样性的并入本发明的队列文库。 还公开了用于制备和筛选这种用于分离适合治疗疾病的治疗剂的队列文库的方法。
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公开(公告)号：US20090117124A1
公开(公告)日：2009-05-07
申请号：US12080419
申请日：2008-04-01
Applicant: Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
Inventor： Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
CPC classification number: C07K16/4291 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S424/805
Abstract: The present invention relates to novel human antibodies specifically directed against human immunoglobulin E (anti-IgE). The present invention also relates to pharmaceutical compositions and methods for treating asthma, in particular allergic asthma, as well as other IgE-mediated disorders including allergic rhinitis and food allergies.
Abstract translation: 本发明涉及专门针对人免疫球蛋白E（抗IgE）的新型人抗体。 本发明还涉及用于治疗哮喘，特别是过敏性哮喘以及其它IgE介导的疾病，包括过敏性鼻炎和食物过敏的药物组合物和方法。
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3.发明申请Antibody Ultrahumanization by Predicted Mature CDR Blasting and Cohort Library Generation and Screening 有权通过预测成熟的CDR爆破和队列库生成和筛选的抗体超人性化公开(公告)号：US20090318297A1
公开(公告)日：2009-12-24
申请号：US12085175
申请日：2006-11-10
Applicant: Guido Cappucilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Rarnesh Bhatt , Nurten Beyaz-Kavuncu
Inventor： Guido Cappucilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Rarnesh Bhatt , Nurten Beyaz-Kavuncu
CPC classification number: C07K16/005 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/565 , C07K2317/622
Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
Abstract translation: 公开了针对改进的通用抗体文库的方法和组合物，其合理开发参考抗体文库（例如通用抗体文库）中所含的人类多样性信息。 所公开的方法涉及使用查询CDR序列来引导参与文库中存在的人抗体多样性的并入本发明的队列文库。 还公开了用于制备和筛选这种用于分离适合治疗疾病的治疗剂的队列文库的方法。
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公开(公告)号：US20110064726A1
公开(公告)日：2011-03-17
申请号：US12954196
申请日：2010-11-24
Applicant: Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
Inventor： Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
CPC classification number: C07K16/4291 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S424/805
Abstract: The present invention relates to novel human antibodies specifically directed against human immunoglobulin E (anti-IgE). The present invention also relates to pharmaceutical compositions and methods for treating asthma, in particular allergic asthma, as well as other IgE-mediated disorders including allergic rhinitis and food allergies.
Abstract translation: 本发明涉及专门针对人免疫球蛋白E（抗IgE）的新型人抗体。 本发明还涉及用于治疗哮喘，特别是过敏性哮喘以及其它IgE介导的疾病，包括过敏性鼻炎和食物过敏的药物组合物和方法。
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公开(公告)号：US07867494B2
公开(公告)日：2011-01-11
申请号：US12080419
申请日：2008-04-01
Applicant: Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
Inventor： Wai Liu , Mike Yeadon , Isabelle de Mendez , Alison Logan , Gerald F. Casperson , Arvind Rajpal , Mark A. Moffat , Wei Liao , Caroline Brown , Nurten Beyaz-Kavuncu , Judith Diaz-Collier , Sirid-Aimee Kellermann
IPC: A61K39/395
CPC classification number: C07K16/4291 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S424/805
Abstract: The present invention relates to novel human antibodies specifically directed against human immunoglobulin E (anti-IgE). The present invention also relates to pharmaceutical compositions and methods for treating asthma, in particular allergic asthma, as well as other IgE-mediated disorders including allergic rhinitis and food allergies.
Abstract translation: 本发明涉及专门针对人免疫球蛋白E（抗IgE）的新型人抗体。 本发明还涉及用于治疗哮喘，特别是过敏性哮喘以及其它IgE介导的疾病，包括过敏性鼻炎和食物过敏的药物组合物和方法。
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