-
公开(公告)号：US20060024308A1
公开(公告)日：2006-02-02
申请号：US11176525
申请日：2005-07-06
Applicant: Roberto Crea , Arvind Rajpal , Toshihiko Takeuchi , Guido Cappuccilli
Inventor： Roberto Crea , Arvind Rajpal , Toshihiko Takeuchi , Guido Cappuccilli
IPC: C07K16/24 , A61K39/395
CPC classification number: C07K16/241 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
Abstract: An isolated human anti-TNF-α antibody, or antigen-binding portion thereof, containing at least one high-affinity VL or VH antibody chain that is effective, when substituted for the corresponding VL or VH chain of the anti-TNF-α scFv antibody having sequence SEQ ID NO: 1, to bind to human TNF-α with a Koff rate constant that is at least 1.5 fold lower than that of the antibody having SEQ ID NO: 1, when determined under identical conditions.
Abstract translation: 包含至少一种高亲和力V L或V H H抗体链的分离的人抗TNF-α抗体或其抗原结合部分，其有效，当 代替具有序列SEQ ID NO：1的抗TNF-αscFv抗体的相应的V L或V H H链与人TNF-α结合， 当相同条件下测定时，其比例为具有SEQ ID NO：1的抗体的至少1.5倍的速率常数。
-
公开(公告)号：US11674240B2
公开(公告)日：2023-06-13
申请号：US11571710
申请日：2005-07-06
Applicant: Roberto Crea , Arvind Rajpal , Guido Cappuccilli , Randy Shen , Toshihiko Takeuchi
Inventor： Roberto Crea , Arvind Rajpal , Guido Cappuccilli , Randy Shen , Toshihiko Takeuchi
CPC classification number: C40B40/08 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622
Abstract: Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed.
-
公开(公告)号：US20110124527A1
公开(公告)日：2011-05-26
申请号：US12850219
申请日：2010-08-04
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
IPC: C40B50/00
CPC classification number: C07K16/241 , C07K14/78 , C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C07K2319/30 , C12N15/1044
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Abstract translation: 描述了直通诱变和自然变体组合纤连蛋白III（FN3）多肽文库以及它们的构建和使用方法。 还公开了通过针对多种选择的抗原筛选文库而选择的多种高结合亲和力多肽。
-
公开(公告)号：US20100152063A1
公开(公告)日：2010-06-17
申请号：US12562992
申请日：2009-09-18
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
CPC classification number: C07K14/78 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C12N15/1044
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Abstract translation: 描述了直通诱变和自然变体组合纤连蛋白III（FN3）多肽文库以及它们的构建和使用方法。 还公开了通过针对多种选择的抗原筛选文库而选择的多种高结合亲和力多肽。
-
公开(公告)号：US09376483B2
公开(公告)日：2016-06-28
申请号：US13899698
申请日：2013-05-22
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
CPC classification number: C07K14/78 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C12N15/1044 , C40B40/10
Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
-
Patent Agency Ranking
公开(公告)号：US09315536B2
公开(公告)日：2016-04-19
申请号：US12438986
申请日：2007-08-29
Applicant: Roberto Crea , Guido Cappuccilli
Inventor： Roberto Crea , Guido Cappuccilli
Abstract: A composition comprising individual single-stranded oligonucleotides capable of self assembling to form a pair of complementary, substantially contiguous single strands of a double-stranded nucleic acid filament, and a method for forming such filaments are disclosed.
Abstract translation: 公开了包含能够自组装以形成双链核酸丝的一对互补的，基本相邻的单链的单个单链寡核苷酸的组合物和形成这种细丝的方法。
-
7.发明授权Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening 有权通过预测成熟的CDR爆破和队列文库生成和筛选，抗体超人性化公开(公告)号：US08716195B2
公开(公告)日：2014-05-06
申请号：US12085175
申请日：2006-11-10
Applicant: Guido Cappuccilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Ramesh R. Bhatt , Nurten Beyaz-Kavuncu
Inventor： Guido Cappuccilli , Roberto Crea , Takeuchi Toshihilo , Randy Shen , Ramesh R. Bhatt , Nurten Beyaz-Kavuncu
IPC: C40B50/06
CPC classification number: C07K16/005 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/565 , C07K2317/622
Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
Abstract translation: 公开了针对改进的通用抗体文库的方法和组合物，其合理开发参考抗体文库（例如通用抗体文库）中所含的人类多样性信息。 所公开的方法涉及使用查询CDR序列来引导参与文库中存在的人抗体多样性的并入本发明的队列文库。 还公开了用于制备和筛选这种用于分离适合治疗疾病的治疗剂的队列文库的方法。
-
公开(公告)号：US20090176654A1
公开(公告)日：2009-07-09
申请号：US12228404
申请日：2008-08-11
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
CPC classification number: C07K16/241 , C07K14/78 , C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C07K2319/30 , C12N15/1044
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Abstract translation: 描述了直通诱变和自然变体组合纤连蛋白III（FN3）多肽文库以及它们的构建和使用方法。 还公开了通过针对多种选择的抗原筛选文库而选择的多种高结合亲和力多肽。
-
公开(公告)号：US08697608B2
公开(公告)日：2014-04-15
申请号：US12850219
申请日：2010-08-04
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
IPC: C40B50/06
CPC classification number: C07K16/241 , C07K14/78 , C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C07K2319/30 , C12N15/1044
Abstract: Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Abstract translation: 描述了直通诱变和自然变体组合纤连蛋白III（FN3）多肽文库以及它们的构建和使用方法。 还公开了通过针对多种选择的抗原筛选文库而选择的多种高结合亲和力多肽。
-
公开(公告)号：US08470966B2
公开(公告)日：2013-06-25
申请号：US12820018
申请日：2010-06-21
Applicant: Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
Inventor： Guido Cappuccilli , Roberto Crea , Randy Shen , Craig A. Hokanson , Peter B. Kirk , David R. Liston
IPC: C70K4/00
CPC classification number: C07K14/78 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C12N15/1044 , C40B40/10
Abstract: Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having high binding affinities, e.g., greater than 300 nM, for VEGFR2 or Axl proteins.
Abstract translation: 描述了纤连蛋白III型（FN3）多肽文库以及它们在鉴定对VEGFR2或Ax1蛋白具有高结合亲和力（例如大于300nM）的纤连蛋白型结合肽的用途。
-
-
-
-
-
-
-
-
-
Search Results
18
records
(took 0.029 seconds)
