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    Coating composition for the dip coating of capsule halves
    1.
    发明授权
    Coating composition for the dip coating of capsule halves 有权
    涂料组合物用于胶囊半浸涂

    公开(公告)号：US09107451B2

    公开(公告)日：2015-08-18

    申请号：US12845994

    申请日：2010-07-29

    申请人： Brigitte Skalsky ,  Manfred Aβmus ,  Odette Hensel ,  Hans-Ulrich Petereit

    发明人： Brigitte Skalsky ,  Manfred Aβmus ,  Odette Hensel ,  Hans-Ulrich Petereit

    IPC分类号： A61K9/64 ,  A23P1/04 ,  A23L1/00 ,  A61K9/48 ,  A61K47/32

    CPC分类号： A23P1/04 ,  A23P10/30 ,  A61K9/4891 ,  A61K47/32

    摘要： A coating composition for the enteric coating of capsule halves made of water-soluble or water-swellable polymer material in a dipping process is provided. The composition is an aqueous dispersion or solution, containing a polymer mixture of at least one first (meth)acrylate copolymer, which is enteric, and at least one further (meth)acrylate copolymer, which is enteric or water-insoluble, and also auxiliaries which influence the viscosity of the dispersion and the elasticity of the dried polymer film. The solids content of the dispersion or solution is more than 25% by weight and the viscosity is 150 to 1500 mPa·s and a dried film produced from the dispersion or solution has an elongation at break of at least 200%. Also provided is a capsule composed of two capsule halves coated with the dispersion or solution in a dipping process does. The enteric capsule does not dissolve in 0.1 N HCl at pH 1.2 after two hours, but completely dissolves in buffer at pH 6.8 in less than 30 minutes. A method to prepare enteric coated capsule halves is also provided.

    摘要翻译： 提供了一种用于在浸渍过程中由水溶性或水溶胀性聚合物材料制成的胶囊半部的肠溶衣涂料组合物。 该组合物是含有至少一种肠溶性的至少一种第一（甲基）丙烯酸酯共聚物和至少一种其它（甲基）丙烯酸酯共聚物的聚合物混合物的水性分散体或溶液，其为肠溶或水不溶性的，以及辅助剂 这影响了分散体的粘度和干燥的聚合物膜的弹性。 分散体或溶液的固体成分大于25重量％，粘度为150〜1500mPa·s，由分散液或溶液产生的干燥膜的断裂伸长率为200％以上。 还提供了由在浸渍过程中涂覆有分散体或溶液的两个胶囊半部组成的胶囊。 肠溶胶囊在pH2.2后2小时内不溶于0.1N HCl，但在不到30分钟内完全溶于pH 6.8的缓冲液中。 还提供了制备肠溶衣胶囊半部的方法。

    COATING COMPOSITION FOR THE DIP COATING OF CAPSULE HALVES
    2.
    发明申请
    COATING COMPOSITION FOR THE DIP COATING OF CAPSULE HALVES 有权
    涂料组合物用于胶囊的浸涂

    公开(公告)号：US20110033530A1

    公开(公告)日：2011-02-10

    申请号：US12845994

    申请日：2010-07-29

    申请人： Brigitte SKALSKY ,  Manfred Assmus ,  Odette Hensel ,  Hans-Ulrich Petereit

    发明人： Brigitte SKALSKY ,  Manfred Assmus ,  Odette Hensel ,  Hans-Ulrich Petereit

    IPC分类号： A61K9/48 ,  A61K47/32 ,  B05D5/00 ,  A23P1/08

    CPC分类号： A23P1/04 ,  A23P10/30 ,  A61K9/4891 ,  A61K47/32

    摘要： A coating composition for the enteric coating of capsule halves made of water-soluble or water-swellable polymer material in a dipping process is provided. The composition is an aqueous dispersion or solution, containing a polymer mixture of at least one first (meth)acrylate copolymer, which is enteric, and at least one further (meth)acrylate copolymer, which is enteric or water-insoluble, and also auxiliaries which influence the viscosity of the dispersion and the elasticity of the dried polymer film. The solids content of the dispersion or solution is more than 25% by weight and the viscosity is 150 to 1500 mPa·s and a dried film produced from the dispersion or solution has an elongation at break of at least 200%. Also provided is a capsule composed of two capsule halves coated with the dispersion or solution in a dipping process does. The enteric capsule does not dissolve in 0.1 N HCl at pH 1.2 after two hours, but completely dissolves in buffer at pH 6.8 in less than 30 minutes. A method to prepare enteric coated capsule halves is also provided.

    摘要翻译： 提供了一种用于在浸渍过程中由水溶性或水溶胀性聚合物材料制成的胶囊半部的肠溶衣涂料组合物。 该组合物是含有至少一种肠溶性的至少一种第一（甲基）丙烯酸酯共聚物和至少一种其它（甲基）丙烯酸酯共聚物的聚合物混合物的水性分散体或溶液，其为肠溶或水不溶性的，以及辅助剂 这影响了分散体的粘度和干燥的聚合物膜的弹性。 分散体或溶液的固体成分大于25重量％，粘度为150〜1500mPa·s，由分散液或溶液制得的干燥膜的断裂伸长率为200％以上。 还提供了由在浸渍过程中涂覆有分散体或溶液的两个胶囊半部组成的胶囊。 肠溶胶囊在pH2.2后2小时内不溶于0.1N HCl，但在不到30分钟内完全溶于pH 6.8的缓冲液中。 还提供了制备肠溶衣胶囊半部的方法。