Antibodies that bind OV064 and methods of use therefor
    5.
    发明授权
    Antibodies that bind OV064 and methods of use therefor 有权
    结合OV064的抗体及其使用方法

    公开(公告)号:US08323645B2

    公开(公告)日:2012-12-04

    申请号:US11886434

    申请日:2006-03-10

    IPC分类号: A61K39/395 C07K16/30

    摘要: Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

    摘要翻译: 公开了结合OV064的抗体的抗体和抗原结合片段。 抗体结合OV064的细胞外结构域。 一些抗体和抗原结合片段结合OV064上足以诱导内化的表位。 在一些实施方案中,抗体是人源化的,嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体,含有核酸的重组细胞,以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。

    Antibodies That Bind OV064 and Methods of Use Therefor
    8.
    发明申请
    Antibodies That Bind OV064 and Methods of Use Therefor 有权
    绑定OV064的抗体及其使用方法

    公开(公告)号:US20090208489A1

    公开(公告)日:2009-08-20

    申请号:US11886434

    申请日:2006-03-10

    摘要: Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

    摘要翻译: 公开了结合OV064的抗体的抗体和抗原结合片段。 抗体结合OV064的细胞外结构域。 一些抗体和抗原结合片段结合OV064上足以诱导内化的表位。 在一些实施方案中,抗体是人源化的,嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体,含有核酸的重组细胞,以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。