-
1.发明申请CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders 审中-公开CCR1抑制剂可用于治疗多发性骨髓瘤和其他疾病公开(公告)号：US20090286823A1
公开(公告)日：2009-11-19
申请号：US12316901
申请日：2008-12-17
IPC分类号： A61K31/4545 , A61P35/00
CPC分类号： A61K31/4353
摘要： The invention relates to the use of inhibitors of CCR1 for the treatment of cancers and osteolytic bone disorders. In some embodiments, the invention relates to methods for the treatment of multiple myeloma, smoldering multiple myeloma and secondary bone cancers.
摘要翻译： 本发明涉及CCR1抑制剂用于治疗癌症和溶骨性骨病的用途。 在一些实施方案中，本发明涉及治疗多发性骨髓瘤，闷烧多发性骨髓瘤和继发性骨癌的方法。
-
2.发明申请CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS 审中-公开CCR1抑制剂用于多发性骨髓瘤和其他疾病的治疗公开(公告)号：US20130040979A1
公开(公告)日：2013-02-14
申请号：US13423447
申请日：2012-03-19
IPC分类号： A61K31/4545 , A61P35/00
CPC分类号： A61K31/4353
摘要： The invention relates to the use of inhibitors of CCR1 for the treatment of cancers and osteolytic bone disorders. In some embodiments, the invention relates to methods for the treatment of multiple myeloma, smoldering multiple myeloma and secondary bone cancers.
摘要翻译： 本发明涉及CCR1抑制剂用于治疗癌症和溶骨性骨病的用途。 在一些实施方案中，本发明涉及治疗多发性骨髓瘤，闷烧多发性骨髓瘤和继发性骨癌的方法。
-
公开(公告)号：US20140328751A1
公开(公告)日：2014-11-06
申请号：US14249299
申请日：2014-04-09
申请人： Ole Petter Veiby , John S. Babcook
发明人： Ole Petter Veiby , John S. Babcook
IPC分类号： A61K47/48 , G01N33/574 , A61K51/10 , C07K16/30
CPC分类号： C07K16/3069 , A61K31/5365 , A61K47/6851 , A61K47/6853 , A61K47/6869 , A61K51/1045 , A61K51/1072 , A61K51/1093 , A61K2039/505 , C07K16/00 , C07K16/28 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , G01N33/57484 , G01N33/57492 , G01N2333/705
摘要： Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
摘要翻译： 公开了结合OV064的抗体的抗体和抗原结合片段。 抗体结合OV064的细胞外结构域。 一些抗体和抗原结合片段结合OV064上足以诱导内化的表位。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。
-
4.发明授权Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer 有权用于鉴别，评估，预防和治疗乳腺癌和卵巢癌的组合物，试剂盒和方法公开(公告)号：US07494775B2
公开(公告)日：2009-02-24
申请号：US11080991
申请日：2005-03-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K16/28 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N33/6893 , G01N2333/47 , G01N2500/20
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌或卵巢癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌或卵巢癌的组合物，试剂盒和方法。
-
5.发明申请Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer 有权用于鉴别，评估，预防和治疗乳腺癌和卵巢癌的组合物，试剂盒和方法公开(公告)号：US20100003682A1
公开(公告)日：2010-01-07
申请号：US12317003
申请日：2008-12-17
CPC分类号： C12Q1/6886 , C07K16/28 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N33/6893 , G01N2333/47 , G01N2500/20
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌或卵巢癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌或卵巢癌的组合物，试剂盒和方法。
-
6.发明申请ADMINISTRATION OF AN ANTI-GCC ANTIBODY-DRUG CONJUGATE AND A DNA DAMAGING AGENT IN THE TREATMENT OF CANCER 审中-公开治疗癌症的抗GCC抗体药物联合药物和DNA损伤剂的管理公开(公告)号：US20140356383A1
公开(公告)日：2014-12-04
申请号：US14192632
申请日：2014-02-27
申请人： Ole Petter Veiby
发明人： Ole Petter Veiby
IPC分类号： A61K38/05 , A61K31/7068 , A61K33/24 , A61K31/513 , A61K47/48 , A61K31/4745
CPC分类号： A61K38/05 , A61K31/4745 , A61K31/513 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6863 , A61K47/6871 , A61K2039/505 , C07K16/3046 , C07K16/40 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to methods for the treatment of gastrointestinal cancers. In particular, the invention provides methods for treatment of a gastrointestinal cancer by administering an immunoconjugate comprising an anti-GCC antibody molecule in combination with a DNA damaging agent.
摘要翻译： 本发明涉及治疗胃肠癌的方法。 特别地，本发明提供了通过与DNA损伤剂组合施用包含抗GCC抗体分子的免疫缀合物来治疗胃肠癌的方法。
-
公开(公告)号：US08323645B2
公开(公告)日：2012-12-04
申请号：US11886434
申请日：2006-03-10
申请人： Ole Petter Veiby , John S. Babcook
发明人： Ole Petter Veiby , John S. Babcook
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/30 , A61K47/6849 , A61K47/6869 , A61K2039/505 , C07K16/2827 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
摘要翻译： 公开了结合OV064的抗体的抗体和抗原结合片段。 抗体结合OV064的细胞外结构域。 一些抗体和抗原结合片段结合OV064上足以诱导内化的表位。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。
-
公开(公告)号：US20160319030A1
公开(公告)日：2016-11-03
申请号：US15216570
申请日：2016-07-21
申请人： Ole Petter Veiby , John S. Babcook
发明人： Ole Petter Veiby , John S. Babcook
IPC分类号： C07K16/30 , A61K51/10 , A61K47/48 , A61K31/5365 , C07K16/28 , G01N33/574
CPC分类号： C07K16/3069 , A61K31/5365 , A61K47/6851 , A61K47/6853 , A61K47/6869 , A61K51/1045 , A61K51/1072 , A61K51/1093 , A61K2039/505 , C07K16/00 , C07K16/28 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , G01N33/57484 , G01N33/57492 , G01N2333/705
摘要： Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
-
9.发明授权Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer 有权用于鉴别，评估，预防和治疗乳腺癌和卵巢癌的组合物，试剂盒和方法公开(公告)号：US08323906B2
公开(公告)日：2012-12-04
申请号：US12317003
申请日：2008-12-17
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , C07K16/28 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N33/6893 , G01N2333/47 , G01N2500/20
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.
摘要翻译： 本发明涉及新发现的与乳腺癌或卵巢癌相关的核酸分子和蛋白质。 提供了用于检测，表征，预防和治疗人乳腺癌或卵巢癌的组合物，试剂盒和方法。
-
公开(公告)号：US20090208489A1
公开(公告)日：2009-08-20
申请号：US11886434
申请日：2006-03-10
申请人： Ole Petter Veiby , John S. Babcook
发明人： Ole Petter Veiby , John S. Babcook
IPC分类号： A61K39/395 , C07K16/30 , C12N15/85 , C12N5/10 , G01N33/574 , C12N5/12 , A61P35/00
CPC分类号： C07K16/30 , A61K47/6849 , A61K47/6869 , A61K2039/505 , C07K16/2827 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
摘要翻译： 公开了结合OV064的抗体的抗体和抗原结合片段。 抗体结合OV064的细胞外结构域。 一些抗体和抗原结合片段结合OV064上足以诱导内化的表位。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.033 秒)
