公开(公告)号：US08674063B2

公开(公告)日：2014-03-18

申请号：US12513085

申请日：2007-10-30

申请人： Glay Chinea Santiago ,  Vivian Huerta Galindo ,  Alejandro Miguel Martin Dunn ,  Noralvis Fleitas Salazar ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Mónica Sarría Núñez ,  Alexis Musacchio Lasa ,  Olvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Anìa Cabrales Rico

发明人： Glay Chinea Santiago ,  Vivian Huerta Galindo ,  Alejandro Miguel Martin Dunn ,  Noralvis Fleitas Salazar ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Mónica Sarría Núñez ,  Alexis Musacchio Lasa ,  Olvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Anìa Cabrales Rico

IPC分类号： C07K14/00

CPC分类号： A61K47/48315 ,  A61K38/00 ,  A61K47/645 ,  C07K14/005 ,  C07K2319/04 ,  C07K2319/10 ,  C12N2770/24022 ,  C12N2770/24122 ,  C12N2770/24222 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393 ,  Y02A50/395

摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.

摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。