公开(公告)号：US20080187558A1

公开(公告)日：2008-08-07

申请号：US12098150

申请日：2008-04-04

申请人： Henrik H. Jacobi ,  Annette R. Lundegaard ,  Christain G. Houghton ,  Stig Aasmul-Olsen ,  Lise L. Maerkedahl ,  Jan S. Andersen ,  Kerry Mallindine ,  Owen J. Murray ,  Susan G. Banbury ,  Desmond Yik Teng Wong ,  Lisa M. Garrett ,  Michael Hall

发明人： Henrik H. Jacobi ,  Annette R. Lundegaard ,  Christain G. Houghton ,  Stig Aasmul-Olsen ,  Lise L. Maerkedahl ,  Jan S. Andersen ,  Kerry Mallindine ,  Owen J. Murray ,  Susan G. Banbury ,  Desmond Yik Teng Wong ,  Lisa M. Garrett ,  Michael Hall

IPC分类号： A61K39/35 ,  A61P37/08

CPC分类号： A61K9/006 ,  A61J1/035 ,  A61K9/0056 ,  A61K9/19 ,  A61K9/2018 ,  A61K9/2063 ,  A61K9/2095 ,  A61K9/7007 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/542 ,  A61K2039/545 ,  B65D75/327 ,  G01N33/15 ,  G01N33/94 ,  G01N2800/24 ,  Y02A50/472

摘要： The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.

公开(公告)号：US20180108430A1

公开(公告)日：2018-04-19

申请号：US15719382

申请日：2017-09-28

申请人： Alexander H. VO ,  Stephen Smock ,  Anthony K. Williams ,  Ben Raimer ,  Owen J. Murray ,  Ryan S. Westberry ,  David L. Callender ,  Kelly Michael Jackson

发明人： Alexander H. VO ,  Stephen Smock ,  Anthony K. Williams ,  Ben Raimer ,  Owen J. Murray ,  Ryan S. Westberry ,  David L. Callender ,  Kelly Michael Jackson

IPC分类号： G16H10/60 ,  G06F17/30 ,  G09B5/06 ,  G09B19/00 ,  G16H50/30 ,  G16H40/67

CPC分类号： G16H10/60 ,  G06F16/951 ,  G09B5/065 ,  G09B19/00 ,  G16H20/00 ,  G16H40/20 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

摘要： Methods and systems are provided for managing patient or patient populations within a fully integrated captivated healthcare system, which includes creating a patient profile or a patient population profile; screening, assessing and treating a patient or patient population; reviewing, analyzing, and comparing a patient or patient population to a control group or pre-treatment patient profile or patient population profile; and prioritizing, scheduling, and care coordination for a patient or patient population as part of follow-up healthcare assessment and services included in the fully integrated healthcare delivery system. Part of the methods and system includes the ability to utilize comparative patient and patient population data to assess and control healthcare access, quality, and costs.

公开(公告)号：US09572645B2

公开(公告)日：2017-02-21

申请号：US13956787

申请日：2013-08-01

申请人： Jonathan B. Levine ,  Owen J. Murray ,  Elmar A. Dave

发明人： Jonathan B. Levine ,  Owen J. Murray ,  Elmar A. Dave

IPC分类号： A61C19/04 ,  A61C19/06 ,  A61C5/14 ,  A61N5/06 ,  A61C13/15

CPC分类号： A61C19/063 ,  A61C5/90 ,  A61C19/003 ,  A61C19/066 ,  A61N5/0624 ,  A61N2005/0606

摘要： A closed system mouthpiece uses light and heat generation to activate a gel formulation to increase its volume. The gel formulation is coated into the mouthpiece, which is inserted into the user's mouth. Application of heat above a threshold temperature causes the gel to transform into foam and expand out of the mouthpiece and into the oral cavity. The mouthpiece creates a hermetic seal such that the foam expands out throughout the oral cavity into nooks and crannies that are normally difficult to access. Activation of a light source embedded within the mouthpiece enhances the bacteria killing properties of the foam material. The pH balance of the mouth is restored by the inventive method and apparatus to a neutral level in the range of 6.75 to 7.25.

摘要翻译： 封闭的系统喉舌使用光和热产生来激活凝胶制剂以增加其体积。 将凝胶制剂涂布到插嘴中，将其插入使用者的口中。 热量高于阈值温度的应用会使凝胶转变成泡沫，并扩展到口腔内并进入口腔。 喉舌产生气密密封，使得泡沫在整个口腔中膨胀成通常难以进入的角落和cran骨。 激活嵌入在口罩内的光源增强泡沫材料的杀菌性能。 通过本发明的方法和装置将嘴巴的pH平衡恢复到6.75至7.25范围内的中性水平。

公开(公告)号：US20080193535A1

公开(公告)日：2008-08-14

申请号：US12098191

申请日：2008-04-04

申请人： Henrik Hugo Jacobi ,  Annette R. Lundegaard ,  Christian G. Houghton ,  Stig Aasmul-Olsen ,  Lise L. Maerkedahl ,  Jan S. Andersen ,  Kerry Mallindin ,  Owen J. Murray ,  Susan G. Banbury ,  Desmond Yik Teng Wong ,  Lisa M. Garrett ,  Michael Hall

发明人： Henrik Hugo Jacobi ,  Annette R. Lundegaard ,  Christian G. Houghton ,  Stig Aasmul-Olsen ,  Lise L. Maerkedahl ,  Jan S. Andersen ,  Kerry Mallindin ,  Owen J. Murray ,  Susan G. Banbury ,  Desmond Yik Teng Wong ,  Lisa M. Garrett ,  Michael Hall

IPC分类号： A61K9/10 ,  A61K39/35

CPC分类号： A61K9/006 ,  A61J1/035 ,  A61K9/0056 ,  A61K9/19 ,  A61K9/2018 ,  A61K9/2063 ,  A61K9/2095 ,  A61K9/7007 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/542 ,  A61K2039/545 ,  B65D75/327 ,  G01N33/15 ,  G01N33/94 ,  G01N2800/24 ,  Y02A50/472

摘要： The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.

摘要翻译： 本发明提供含有过敏原的药物产品，特别是快速分散的固体变应原剂型。 特别地，提供了适合于粘膜粘膜给药的快速分散的非压缩固体剂型，其包含基质和至少一种变应原。 合适的基质是明胶，淀粉和甘露醇。 还提供了剂型的方法。

公开(公告)号：US20150037749A1

公开(公告)日：2015-02-05

申请号：US13956787

申请日：2013-08-01

申请人： Jonathan B. Levine ,  Owen J. Murray ,  Elmar A. Dave

发明人： Jonathan B. Levine ,  Owen J. Murray ,  Elmar A. Dave

IPC分类号： A61C19/06

CPC分类号： A61C19/063 ,  A61C5/90 ,  A61C19/003 ,  A61C19/066 ,  A61N5/0624 ,  A61N2005/0606

摘要： A closed system mouthpiece uses light and heat generation to activate a gel formulation to increase its volume. The gel formulation is coated into the mouthpiece, which is inserted into the user's mouth. Application of heat above a threshold temperature causes the gel to transform into foam and expand out of the mouthpiece and into the oral cavity. The mouthpiece creates a hermetic seal such that the foam expands out throughout the oral cavity into nooks and crannies that are normally difficult to access. Activation of a light source embedded within the mouthpiece enhances the bacteria killing properties of the foam material. The pH balance of the mouth is restored by the inventive method and apparatus to a neutral level in the range of 6.75 to 7.25.

摘要翻译： 封闭的系统喉舌使用光和热产生来激活凝胶制剂以增加其体积。 将凝胶制剂涂布到插嘴中，将其插入使用者的口中。 热量高于阈值温度的应用会使凝胶转变成泡沫，并扩展到口腔内并进入口腔。 喉舌产生气密密封，使得泡沫在整个口腔中膨胀成通常难以进入的角落和口。 激活嵌入在口罩内的光源增强泡沫材料的杀菌性能。 通过本发明的方法和装置将嘴巴的pH平衡恢复到6.75至7.25范围内的中性水平。