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公开(公告)号：US20240352536A1
公开(公告)日：2024-10-24
申请号：US18687177
申请日：2022-08-26
发明人： Claire PALLES , Ik SHIN CHIN
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156
摘要： The invention provides an assay useful in predicting risk of capecitabine-induced toxicity in a subject. The subject may be screened for the presence of at least one polymorphism of the invention. Suitable polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing capecitabine-induced toxicity; a negative result may indicate a decreased risk of developing capecitabine-induced toxicity.
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公开(公告)号：US11099456B2
公开(公告)日：2021-08-24
申请号：US16549842
申请日：2019-08-23
摘要： A photonic device (100) comprising: an optical waveguide (101), and a modulating element (102) that is evanescently coupled to the waveguide (101); wherein the modulating element (102) modifies a transmission, reflection or absorption characteristic of the waveguide (101) dependant on its state, and the state of the modulating element (102) is switchable by an optical switching signal (125) carried by the waveguide (101), or by an electrical signal that heats the modulating element (102).
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公开(公告)号：US20200341503A1
公开(公告)日：2020-10-29
申请号：US16764893
申请日：2018-06-28
摘要： A method of performing a multiplication operation in the optical domain using a device (100) comprising: an optical waveguide (101), and a modulating element (102) that is optically coupled to the optical waveguide (101), the modulating element (102) modifying a transmission, reflection or absorption characteristic of the waveguide (101) dependant on its state, wherein the state of the modulating element (102) is adjustable by a write signal (103). The method comprises: encoding a first value to the write signal (103), using the write signal (103) to map the first value to a state of the modulating element (102); encoding a second value to a read signal (104); producing an output signal intensity as the transmitted or reflected read signal, wherein the product of the first value and the second value is encoded in the output signal intensity.
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公开(公告)号：US20240156431A1
公开(公告)日：2024-05-16
申请号：US18524838
申请日：2023-11-30
发明人： Ross Upton , Paul Leeson
CPC分类号： A61B8/0883 , A61B8/5223 , G06T7/0012 , G06T2207/30048 , G16H30/40
摘要： A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.
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公开(公告)号：US10910859B2
公开(公告)日：2021-02-02
申请号：US15752088
申请日：2016-08-12
发明人： Damien Frost , David Howey
摘要： A smart cell, comprising: a positive terminal; a negative terminal; a switching circuit which is arranged to select between a first switching state in which an energy storage device is connected between the positive terminal and the negative terminal and a second switching state in which bypasses said energy storage device; and an inductor provided between the positive terminal and the negative terminal. The inductor provides a means by which to monitor current changes in the rest of the circuit. The inductor can thus be used to detect current changes as seen by the smart cell and this sensed information can be used to control the smart cell, e.g. to control an energy source (energy storage device) that forms part of the smart cell. As the inductor is part of the smart cell, it forms part of a decentralized controller strategy to regulate the state of charge of cells within a larger system. For example, it may form part of a decentralized controller strategy to regulate the state of charge of serially connected cells of varying capacities.
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公开(公告)号：US20190044491A1
公开(公告)日：2019-02-07
申请号：US16085636
申请日：2017-03-17
摘要： A re-configurable magnetoinductive waveguide (300), comprising a plurality of resonator cells, wherein each resonator cell comprises a primary resonator (110) that is inductively coupled to a primary resonator (110) of at least one other resonator cell, and wherein at least one of the plurality of resonator cells is a controllable cell (100) which further comprises a control element (120), the control element (120) having an active control component (125) that is operable to adjust the impedance of the primary resonator (110) of the controllable cell (100) in response to a control signal; wherein: the control element (120) comprises a secondary resonator, the secondary resonator is inductively coupled to the primary resonator (110), and the active control component (125) is arranged to vary the electrical properties of the secondary resonator in response to the control signal.
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公开(公告)号：US20180267386A1
公开(公告)日：2018-09-20
申请号：US15760945
申请日：2016-09-15
CPC分类号： G02F1/313 , G02F1/0126 , G02F1/19 , G02F3/02 , G11C13/04
摘要： A photonic device (100) comprising: an optical waveguide (101), and a modulating element (102) that is evanescently coupled to the waveguide (101); wherein the modulating element (102) modifies a transmission, reflection or absorption characteristic of the waveguide (101) dependant on its state, and the state of the modulating element (102) is switchable by an optical switching signal (125) carried by the waveguide (101), or by an electrical signal that heats the modulating element (102).
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公开(公告)号：US20180241239A1
公开(公告)日：2018-08-23
申请号：US15752088
申请日：2016-08-12
发明人： Damien FROST , David HOWEY
CPC分类号： H02J7/0093 , G06F17/16 , H02J7/00 , H02J7/0016 , H02J7/0019 , H02J7/007 , H02J2007/0059 , H02J2007/0098
摘要： A smart cell, comprising: a positive terminal; a negative terminal; a switching circuit which is arranged to select between a first switching state in which an energy storage device is connected between the positive terminal and the negative terminal and a second switching state in which bypasses said energy storage device; and an inductor provided between the positive terminal and the negative terminal. The inductor provides a means by which to monitor current changes in the rest of the circuit. The inductor can thus be used to detect current changes as seen by the smart cell and this sensed information can be used to control the smart cell, e.g. to control an energy source (energy storage device) that forms part of the smart cell. As the inductor is part of the smart cell, it forms part of a decentralized controller strategy to regulate the state of charge of cells within a larger system. For example, it may form part of a decentralized controller strategy to regulate the state of charge of serially connected cells of varying capacities.
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公开(公告)号：US11154613B2
公开(公告)日：2021-10-26
申请号：US16087352
申请日：2017-03-24
发明人： Eleanor Barnes , Annette Von Delft , Jose Lorenco
IPC分类号： A61K39/29 , C07K14/005 , A61K39/00
摘要： The invention concerns a fusion polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across: i) HCV genotypes 1a and 1b; ii) HCV genotypes 1 and 3; or iii) HCV genotypes 1 to 6; and wherein at least one of the conserved peptide sequences comprises at least part of a sequence of a non-structural protein of the HCV genotypes; including associated nucleic acid and vector sequences, and use in methods of treatment or prophylaxis, such as vaccination.
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公开(公告)号：US10959698B2
公开(公告)日：2021-03-30
申请号：US16309432
申请日：2017-06-13
发明人： Ross Upton , Paul Leeson
摘要： A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.
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