公开(公告)号：US20230142654A1

公开(公告)日：2023-05-11

申请号：US17788440

申请日：2021-01-15

申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION ,  PIMEDBIO, INC.

发明人： Chun Young IM ,  Sang Hyun MIN ,  Ji Hoon YU ,  Eun Bi KO ,  So Young KIM ,  Seungyeon LEE ,  Dong Kyu CHOI ,  Heejin LEE ,  Ga Young PARK ,  Doohyun LEE ,  Eunmi HONG ,  Hui-Jeon JEON ,  Young-Hoon PARK ,  Ye Ri HAN ,  Nam Hui KIM ,  Jun Woo KIM ,  Bae Jun OH ,  Jeong-Eun PARK ,  Chang Hoon SEO ,  Minsoo SONG ,  Seonggu RO ,  Dongkyu SHIN

IPC分类号： C07C311/29 ,  C07D295/12 ,  C07D295/14 ,  C07D211/10 ,  C07D207/27 ,  C07D209/16 ,  C07D209/14 ,  C07D235/14 ,  C07D235/06 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  C07D209/86

CPC分类号： C07C311/29 ,  C07D295/12 ,  C07D295/14 ,  C07D211/10 ,  C07D207/27 ,  C07D209/16 ,  C07D209/14 ,  C07D235/14 ,  C07D235/06 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  C07D209/86

摘要： The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.