利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

59 条记录 (耗时 0.027 秒)

    Methods of increasing seed yield
    3.
    发明授权
    Methods of increasing seed yield 有权

    公开(公告)号：US11473097B2

    公开(公告)日：2022-10-18

    申请号：US16476641

    申请日：2018-01-10

    申请人： Plant Bioscience Limited

    发明人： Charlotte Miller ,  Michael Bevan

    IPC分类号： C12N15/82 ,  C12Q1/6895

    摘要： The invention relates to methods for increasing seed yield, increasing the total content of protein and/or lipid in seeds and reducing glucosinolate levels by reducing the expression or activity of UPL3. The invention also relates to genetically altered plants characterised by the above phenotypes and methods of producing such plants.

    VIRUS DETECTION
    5.
    发明申请
    VIRUS DETECTION 审中-公开
    病毒检测

    公开(公告)号：US20160185814A1

    公开(公告)日：2016-06-30

    申请号：US14906436

    申请日：2014-07-03

    申请人： UNIVERSITY OF EAST ANGLIA ,  PLANT BIOSCIENCE LIMITED

    发明人： Rob FIELD ,  Martin REZJEK ,  Abdul RASHID ,  David RUSSELL ,  Maria MARIN

    IPC分类号： C07H23/00 ,  G01N33/569

    CPC分类号： C07H23/00 ,  C07H15/04 ,  G01N33/56983 ,  G01N33/587 ,  G01N2333/11 ,  G01N2400/10

    摘要： The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus—for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

    摘要翻译： 本发明提供用于检测利用纳米颗粒的流感病毒的方法和材料，例如金纳米颗粒，包含多个糖缀合物配体的探针，每个糖缀合物配体（GL）具有多个含唾液酸的识别基团（Y ），其中所述多价核心（X）是三价核心，其中每个配体存在3个识别基团，其中所述生物缀合物上的识别基团特异性结合目标流感上的血凝素 病毒。 探针可以包括与纳米颗粒结合的其它配体，其不与流感病毒（例如聚乙二醇基团）特异性结合。 这些可以调节纳米颗粒表面上糖缀合物配体的密度。 探针的结合通过流感病毒特异性的等离子体信号检测。

    Novel Polypeptides Having Endolysin Activity and Uses Thereof
    6.
    发明申请
    Novel Polypeptides Having Endolysin Activity and Uses Thereof 审中-公开
    具有内溶素活性的新型多肽及其用途

    公开(公告)号：US20160040148A1

    公开(公告)日：2016-02-11

    申请号：US14686246

    申请日：2015-04-14

    申请人： Plant Bioscience Limited

    发明人： Melinda Mayer ,  Arjan Narbad

    IPC分类号： C12N9/80 ,  A61K38/50 ,  C12Q1/34

    CPC分类号： C12N9/80 ,  A61K38/00 ,  A61K38/50 ,  C12N1/06 ,  C12N9/2462 ,  C12N2795/10143 ,  C12Q1/34 ,  C12Y302/01017 ,  C12Y305/01028

    摘要： The present invention provides isolated polypeptides comprising a fragment of the amino acid sequence of SEQ ID NO:1, or a variant, derivative or fusion thereof, which is capable of binding specifically to and lysing cells of Clostridium difficile, wherein the polypeptide exhibits greater lytic activity on cells of Clostridium difficile than the polypeptide of SEQ ID NO:1. The invention further provides means for producing the same, methods for killing bacterial cells such as cells of Clostridium difficile, as well as methods for diagnosing, treating and preventing diseases and conditions associated with infection of the same.

    摘要翻译： 本发明提供分离的多肽，其包含SEQ ID NO：1的氨基酸序列的片段或其变体，衍生物或融合物，其能够特异性结合和裂解艰难梭菌细胞，其中所述多肽表现出更大的溶解性 艰难梭菌细胞的活性高于SEQ ID NO：1的多肽。 本发明还提供了制备该方法的方法，用于杀死艰难梭菌细胞等细菌细胞的方法，以及用于诊断，治疗和预防与其感染相关的疾病和病症的方法。

    Glucoraphnin for use in the treatment and/or prevention of diabetes mellitus
    9.
    发明授权
    Glucoraphnin for use in the treatment and/or prevention of diabetes mellitus 有权

    公开(公告)号：US11147825B2

    公开(公告)日：2021-10-19

    申请号：US15738660

    申请日：2016-06-24

    申请人： PLANT BIOSCIENCE LIMITED

    发明人： Richard Mithen

    IPC分类号： A61K36/31 ,  A61K31/7028 ,  A23L33/105 ,  A23L23/00 ,  A23L19/00 ,  A61P3/10

    摘要： A composition comprising glucoraphanin for use in: reducing fasting serum glucose levels in a subject administered with said composition when compared to a subject not administered said composition; and/or preventing diabetes mellitus and/or a condition associated therewith, treating diabetes mellitus and/or a condition associated therewith, or a combination thereof in a subject; wherein the composition is intermittently administered to the subject between about 1 to about 5 times per week such that said subject is administered with a weekly dose of between about 300 to about 2500 μmoles of glucoraphanin, as well as uses of a composition prepared from a high glucosinolate broccoli and/or methods of: reducing fasting serum glucose levels in a subject having elevated fasting serum glucose levels; preventing diabetes mellitus and/or a condition associated therewith in a subject; treating a subject having diabetes mellitus and/or a condition associated therewith; or combinations thereof.

    PROTEIN EXPRESSION SYSTEMS
    10.
    发明申请
    PROTEIN EXPRESSION SYSTEMS 有权

    公开(公告)号：US20210155947A1

    公开(公告)日：2021-05-27

    申请号：US17016191

    申请日：2020-09-09

    申请人： PLANT BIOSCIENCE LIMITED

    发明人： Frank Sainsbury ,  George Peter Lomonossoff

    IPC分类号： C12N15/82

    摘要： The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system.