公开(公告)号：US20070274958A1

公开(公告)日：2007-11-29

申请号：US10553633

申请日：2003-04-19

申请人： Songtao Shi ,  Pamela Robey ,  Stan Gronthos ,  Masako Miura

发明人： Songtao Shi ,  Pamela Robey ,  Stan Gronthos ,  Masako Miura

IPC分类号： C12N5/08 ,  A61K35/32

CPC分类号： A61K35/30 ,  A61K35/12 ,  A61K47/02 ,  C12N5/0602 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0664 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2506/1361 ,  C12N2533/54

摘要： The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.

摘要翻译： 本发明一般涉及产后牙干细胞及其使用方法。 更具体地，本发明在一个方面涉及产后牙髓干细胞，细胞产生牙本质的用途以及细胞的分化。 另一方面，本发明涉及人类产后落叶牙髓多能干细胞，细胞产生牙质的用途以及细胞的分化。

公开(公告)号：US20100272693A1

公开(公告)日：2010-10-28

申请号：US12745231

申请日：2008-10-22

申请人： EunAh Lee ,  Eun Jeon ,  Pamela Robey ,  Kyung Byung Yoon

发明人： EunAh Lee ,  Eun Jeon ,  Pamela Robey ,  Kyung Byung Yoon

IPC分类号： A61L27/54 ,  A61K47/48 ,  A61P19/00 ,  A61K33/42

CPC分类号： A61L27/46 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/08 ,  A61L27/20 ,  A61L27/58 ,  A61L2430/02 ,  C08L5/08

摘要： A method of bone repair that includes applying to a subject a composite that comprises at least one calcium phosphate, at least one polyamine polymer material; and a linking structure covalently crosslinking the calcium phosphate to the polyamine polymer material, wherein the linking structure is covalently bonded to the calcium phosphate via a —O—Si— moiety or an isocyanato moiety and the linking structure is covalently bonded to the polyamine polymer material via amine groups of the polyamine polymer. Also disclosed is a combination of ingredients comprising at least one polyamine polymer; and calcium phosphate particles that are substantially coated with at least one functional group that is covalently reactive with amine groups on the polyamine polymer; wherein the ingredients are adapted for injection into a subject for forming a bone replacement material in vivo.

摘要翻译： 一种骨修复方法，其包括向受试者施用包含至少一种磷酸钙，至少一种聚胺聚合物材料的复合材料; 以及将磷酸钙与聚胺聚合物材料共价交联的连接结构，其中所述连接结构通过-O-Si部分或异氰酸酯基团共价键合到磷酸钙上，并且所述连接结构共价键合到聚胺聚合物材料 通过多胺聚合物的胺基。 还公开了包含至少一种聚胺聚合物的成分的组合; 和基本上涂覆有与多胺聚合物上的胺基共价反应的至少一个官能团的磷酸钙颗粒; 其中所述成分适于注射入受试者以在体内形成骨置换材料。