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    BONE SCAFFOLDS, INJECTABLE BONE REPAIR MATERIALS AND METHODS FOR BONE REPAIR
    1.
    发明申请
    BONE SCAFFOLDS, INJECTABLE BONE REPAIR MATERIALS AND METHODS FOR BONE REPAIR 审中-公开
    骨修复，骨修复材料和骨修复方法

    公开(公告)号：US20100272693A1

    公开(公告)日：2010-10-28

    申请号：US12745231

    申请日：2008-10-22

    申请人： EunAh Lee ,  Eun Jeon ,  Pamela Robey ,  Kyung Byung Yoon

    发明人： EunAh Lee ,  Eun Jeon ,  Pamela Robey ,  Kyung Byung Yoon

    IPC分类号： A61L27/54 ,  A61K47/48 ,  A61P19/00 ,  A61K33/42

    CPC分类号： A61L27/46 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/08 ,  A61L27/20 ,  A61L27/58 ,  A61L2430/02 ,  C08L5/08

    摘要： A method of bone repair that includes applying to a subject a composite that comprises at least one calcium phosphate, at least one polyamine polymer material; and a linking structure covalently crosslinking the calcium phosphate to the polyamine polymer material, wherein the linking structure is covalently bonded to the calcium phosphate via a —O—Si— moiety or an isocyanato moiety and the linking structure is covalently bonded to the polyamine polymer material via amine groups of the polyamine polymer. Also disclosed is a combination of ingredients comprising at least one polyamine polymer; and calcium phosphate particles that are substantially coated with at least one functional group that is covalently reactive with amine groups on the polyamine polymer; wherein the ingredients are adapted for injection into a subject for forming a bone replacement material in vivo.

    摘要翻译： 一种骨修复方法，其包括向受试者施用包含至少一种磷酸钙，至少一种聚胺聚合物材料的复合材料; 以及将磷酸钙与聚胺聚合物材料共价交联的连接结构，其中所述连接结构通过-O-Si部分或异氰酸酯基团共价键合到磷酸钙上，并且所述连接结构共价键合到聚胺聚合物材料 通过多胺聚合物的胺基。 还公开了包含至少一种聚胺聚合物的成分的组合; 和基本上涂覆有与多胺聚合物上的胺基共价反应的至少一个官能团的磷酸钙颗粒; 其中所述成分适于注射入受试者以在体内形成骨置换材料。