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公开(公告)号：US20190177685A1
公开(公告)日：2019-06-13
申请号：US16284878
申请日：2019-02-25
Applicant: Stan Gronthos , Andrew Christopher William Zannettino
Inventor： Stan Gronthos , Andrew Christopher William Zannettino
IPC: C12N5/0735 , C12N5/0775 , A61K35/28 , A61L27/38 , A61K38/20 , A61K38/19 , A61K38/18
Abstract: The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1bri and ALP. The present invention also relates to methods for producing MEMP's and to uses of MEMP's for therapeutic applications.
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公开(公告)号：US20160264683A1
公开(公告)日：2016-09-15
申请号：US15167934
申请日：2016-05-27
Applicant: Stan Gronthos , Andrew Christopher William Zannettino , John Paul Simmons
IPC: C07K16/40 , G01N33/577
CPC classification number: C07K16/40 , A61K2035/124 , C07K2317/76 , C12N5/0081 , C12N5/0663 , C12N5/163 , C12N2533/56 , C12Q1/42 , G01N33/577 , G01N33/68 , G01N2333/916
Abstract: The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.
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公开(公告)号：US20150307608A1
公开(公告)日：2015-10-29
申请号：US14795449
申请日：2015-07-09
Applicant: Stan Gronthos , Andrew Christopher William Zannettino
Inventor： Stan Gronthos , Andrew Christopher William Zannettino
IPC: C07K16/28 , A61K35/28 , G01N33/569
CPC classification number: C07K16/28 , A61K35/28 , A61K2035/124 , C07K16/18 , C07K2317/24 , C12N5/0663 , G01N33/5044 , G01N33/56966 , G01N2333/4703
Abstract: The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds human and ovine HSP-90beta and its use for enriching multipotential cells such as mesenchymal precursor cells (MPCs).
Abstract translation: 本发明涉及特异性结合人和绵羊HSP-90beta的STRO-4单克隆抗体及其用于富集多潜能细胞如间充质前体细胞（MPC）的用途。
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公开(公告)号：US20110189696A1
公开(公告)日：2011-08-04
申请号：US13059448
申请日：2009-08-18
Applicant: Stan Gronthos , Andrew Christopher Williem Zannellino
Inventor： Stan Gronthos , Andrew Christopher Williem Zannellino
CPC classification number: C07K16/28 , A61K35/28 , A61K2035/124 , C07K16/18 , C07K2317/24 , C12N5/0663 , G01N33/5044 , G01N33/56966 , G01N2333/4703
Abstract: The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds human and ovine HSP-90beta and its use for enriching multipotential cells such a mesenchymal precursor cells (MPCs).
Abstract translation: 本发明涉及特异性结合人和绵羊HSP-90β的STRO-4单克隆抗体及其用于富集多潜能细胞如间充质前体细胞（MPC）的用途。
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公开(公告)号：US07122178B1
公开(公告)日：2006-10-17
申请号：US10030411
申请日：2000-07-07
Applicant: Paul Simmons , Andrew Zannettino , Stan Gronthos
Inventor： Paul Simmons , Andrew Zannettino , Stan Gronthos
CPC classification number: C12N5/0663 , A61K2035/124 , C12N2500/42 , C12N2501/39
Abstract: A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilizing MACS recognizing expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilizing two color FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.
Abstract translation: 富含间充质前体的方法包括基于至少两种标记物富集细胞的步骤。 标记可能是i）对间质前体细胞特异性标志物的存在，ii）不存在对分化的间充质细胞特异性的标记，或iii）对间充质前体细胞特异的标志物的表达水平。 该方法可以包括利用识别STRO-1 Mab抗原表达的MACS的第一固相分选步骤，随后使用两色FACS来筛选高水平STRO-1抗原表达的存在的第二分选步骤，以及 VCAM-1的表达。
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Patent Agency Ranking
公开(公告)号：US20060008452A1
公开(公告)日：2006-01-12
申请号：US11178920
申请日：2005-07-11
Applicant: Paul Simmons , Andrew Zannettino , Stan Gronthos
Inventor： Paul Simmons , Andrew Zannettino , Stan Gronthos
CPC classification number: C12N5/0663 , A61K2035/124 , C12N2500/42 , C12N2501/39
Abstract: A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilizing MACS recognizing expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilizing two color FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.
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公开(公告)号：US20160361362A1
公开(公告)日：2016-12-15
申请号：US14456534
申请日：2014-08-11
Applicant: Simon Andrea KOBLAR , Stan GRONTHOS , Agnieszka ARTHUR
Inventor： Simon Andrea KOBLAR , Stan GRONTHOS , Agnieszka ARTHUR
CPC classification number: A61K35/28 , A61K9/0085 , A61K38/00 , A61K38/195 , A61K2035/124 , C12N5/0663 , C12N5/0664
Abstract: The present disclosure provides methods of improving cerebral function or preventing loss of cerebral function and/or treating or preventing a movement disorder and/or regenerating cerebral neurons in a subject who has suffered a stroke, the method comprising administering to the subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
Abstract translation: 本公开提供了改善脑功能或预防脑功能丧失和/或治疗或预防患有中风的受试者的运动障碍和/或再生脑神经元的方法，所述方法包括向受试者施用细胞群体 富集STRO-1 +细胞和/或其后代和/或由其衍生的可溶性因子。
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8.发明申请公开(公告)号：US20160317581A1
公开(公告)日：2016-11-03
申请号：US14871234
申请日：2015-09-30
Applicant: Stan Gronthos , Andrew Zannettino
Inventor： Stan Gronthos , Andrew Zannettino
IPC: A61K35/28 , C12N5/0775 , A61K9/00
Abstract: Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as STRO-1 and CD146/MUC18. The perivascular mesenchymal precursor cell is shown to induce neovascularisation and improvement in cardiac function. Suitable administration of preparations of the mesenchymal precursor cells are useful for treatment of cardiovascular diseases, cerebrovascular diseases and peripheral vascular diseases.
Abstract translation: 间充质前体细胞已经使用血管周围标志物从一系列组织的血管周围位置中分离出来。 描述了新的间充质前体细胞表型，其特征在于存在血管周围标志物3G5，优选还包括α平滑肌肌动蛋白以及早期发育标志物如STRO-1和CD146 / MUC18。 显示血管周围间充质前体细胞诱导心脏功能的新生血管形成和改善。 间充质前体细胞的制剂的合适施用可用于治疗心血管疾病，脑血管疾病和外周血管疾病。
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公开(公告)号：US09175264B2
公开(公告)日：2015-11-03
申请号：US10553633
申请日：2003-04-19
Applicant: Songtao Shi , Pamela Gehron Robey , Stan Gronthos , Masako Miura
Inventor： Songtao Shi , Pamela Gehron Robey , Stan Gronthos , Masako Miura
IPC: C12N5/071 , C12N5/079 , C12N5/0775 , A61K35/12
CPC classification number: A61K35/30 , A61K35/12 , A61K47/02 , C12N5/0602 , C12N5/0618 , C12N5/0654 , C12N5/0664 , C12N2501/11 , C12N2501/115 , C12N2506/1361 , C12N2533/54
Abstract: The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
Abstract translation: 本发明一般涉及产后牙干细胞及其使用方法。 更具体地，本发明在一个方面涉及产后牙髓干细胞，细胞产生牙本质的用途以及细胞的分化。 另一方面，本发明涉及人类产后落叶牙髓多能干细胞，细胞产生牙质的用途以及细胞的分化。
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10.发明申请METHOD OF ENHANCING PROLIFERATION AND/OR SURVIVAL OF MESENCHYMAL PRECURSOR CELLS (MPC) 审中-公开增强和/或存活前列腺细胞（MPC）的方法公开(公告)号：US20150072422A1
公开(公告)日：2015-03-12
申请号：US14470769
申请日：2014-08-27
Applicant: Stan Gronthos , Andrew Christopher William Zannettino
Inventor： Stan Gronthos , Andrew Christopher William Zannettino
IPC: C12N5/077
CPC classification number: C12N5/0652 , C12N5/0663 , C12N2501/125 , C12N2501/135 , C12N2501/22 , C12N2501/2301 , C12N2501/2303 , C12N2501/2306 , C12N2501/25 , C12N2501/999 , C12N2502/13
Abstract: The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.
Abstract translation: 本发明涉及在体外或体内增强间充质前体细胞（MPC）和/或其衍生的后代的增殖和/或存活的方法，包括将MPC或后代暴露于SDF-1或其类似物。 本发明还涉及包含分离的MPC或由其衍生的后代和SDF-1或其类似物的组合物。 本发明还涉及使用这些方法和组合物用于哺乳动物体内或体内骨形成。
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