公开(公告)号：US11572386B2

公开(公告)日：2023-02-07

申请号：US15508928

申请日：2015-08-29

申请人： AURO PEPTIDES LTD ,  Suresh Kumar Vadlamani ,  Patil Nilesh Dagadu ,  Shafee Mohammed Abdul ,  Sanjay Devidas Patil ,  Govindrajan Narayanan

发明人： Suresh Kumar Vadlamani ,  Patil Nilesh Dagadu ,  Shafee Mohammed Abdul ,  Sanjay Devidas Patil ,  Govindrajan Narayanan

IPC分类号： C07K7/08 ,  B01D15/32 ,  B01D15/42

摘要： The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and oxidizing agent followed by purification using RP-HPLC.

公开(公告)号：US10344069B2

公开(公告)日：2019-07-09

申请号：US15523384

申请日：2015-10-31

申请人： Auro Peptides Ltd ,  Suresh Kumar Vadlamani ,  Patil Nilesh Dagadu ,  Mohammed Abdul Shafee ,  Sanjay Devidas Patil ,  Nagana Goud Agasaladinni

发明人： Suresh Kumar Vadlamani ,  Patil Nilesh Dagadu ,  Mohammed Abdul Shafee ,  Sanjay Devidas Patil ,  Nagana Goud Agasaladinni

IPC分类号： C07K14/605

摘要： The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.