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    Compounds for the treatment of neurodegenerative diseases
    1.
    发明授权
    Compounds for the treatment of neurodegenerative diseases 有权
    用于治疗神经变性疾病的化合物

    公开(公告)号：US09284271B2

    公开(公告)日：2016-03-15

    申请号：US13993756

    申请日：2011-12-13

    申请人： Gerard Griffioen ,  Tom Van Dooren ,  Verónica Rojas De La Parra ,  Arnaud Marchand ,  Sara Alassia ,  Amuri Kilonda ,  Patrick Chaltin

    发明人： Gerard Griffioen ,  Tom Van Dooren ,  Verónica Rojas De La Parra ,  Arnaud Marchand ,  Sara Alassia ,  Amuri Kilonda ,  Patrick Chaltin

    IPC分类号： C07D209/14 ,  C07D209/18 ,  C07D401/12 ,  C07D409/12 ,  C07D471/04

    CPC分类号： C07D209/18 ,  C07D209/14 ,  C07D401/12 ,  C07D409/12 ,  C07D471/04

    摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R1, R2, R4, R5, R6, E, n, Y1, Y2, Y3, Y4, Y5, B, R8, and m are as defined in the claims.

    摘要翻译： 本发明提供了新的化合物和用作药物的新化合物，更特别是用于预防或治疗神经变性疾病，更具体地，某些神经系统疾病，例如统称为tau蛋白病的病症，以及细胞毒性α-突触核蛋白淀粉样变性特征的病症 。 本发明还涉及所述新化合物在制备可用于治疗这种神经变性疾病的药物中的用途。 本发明还涉及包含所述新化合物的药物组合物和制备所述新化合物的方法。 化合物具有式（A1），其中R1，R2，R4，R5，R6，E，n，Y1，Y2，Y3，Y4，Y5，B，R8和m如权利要求中所定义。

    Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors
    2.
    发明授权
    Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors 有权
    噻吩并[2,3-B]吡啶衍生物作为病毒复制抑制剂

    公开(公告)号：US08785638B2

    公开(公告)日：2014-07-22

    申请号：US13320519

    申请日：2010-05-17

    申请人： Dorothée Bardiot ,  Patrick Chaltin ,  Frauke Christ ,  Zeger Debyser ,  Marc De Maeyer ,  Arnaud Marchand ,  Damien Marchand ,  Arnout Voet

    发明人： Dorothée Bardiot ,  Patrick Chaltin ,  Frauke Christ ,  Zeger Debyser ,  Marc De Maeyer ,  Arnaud Marchand ,  Damien Marchand ,  Arnout Voet

    IPC分类号： C07D513/04 ,  A61K31/4365

    CPC分类号： C07D495/20 ,  A61K31/4365 ,  A61K31/4375 ,  A61K45/06 ,  C07D495/04 ,  C07D495/14

    摘要： The present invention relates to a series of compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutic amount of such compounds, optionally combined with one or more other drugs having anti-viral activity.

    摘要翻译： 本发明涉及具有抗病毒活性的一系列化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。 本发明还涉及制备这些化合物的方法，以及可用于这种合成的一个或多个步骤的新型中间体。 本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。 本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。 本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

    NOVEL ANTIVIRAL COMPOUNDS
    5.
    发明申请
    NOVEL ANTIVIRAL COMPOUNDS 审中-公开
    新型抗病毒化合物

    公开(公告)号：US20120316161A1

    公开(公告)日：2012-12-13

    申请号：US13518434

    申请日：2010-12-20

    申请人： Gunter Carlens ,  Patrick Chaltin ,  Frauke Christ ,  Zeger Debyser ,  Arnaud Marchand ,  Damien Marchand ,  Arnout Voet ,  Marc De Maeyer

    发明人： Gunter Carlens ,  Patrick Chaltin ,  Frauke Christ ,  Zeger Debyser ,  Arnaud Marchand ,  Damien Marchand ,  Arnout Voet ,  Marc De Maeyer

    IPC分类号： C07D487/04 ,  C07D471/04 ,  A61P31/18 ,  A61K31/538 ,  A61P31/12 ,  A61K31/519 ,  A61K31/437

    CPC分类号： C07D487/04

    摘要： The present invention relates to compounds of formula (A) as defined herein having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

    摘要翻译： 本发明涉及具有抗病毒活性的本文定义的式（A）化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。 本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。 本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。 本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

    NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    9.
    发明申请
    NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权
    用于治疗神经损伤性疾病的新型化合物

    公开(公告)号：US20130289033A1

    公开(公告)日：2013-10-31

    申请号：US13993756

    申请日：2011-12-13

    申请人： Gerard Griffioen ,  Tom Van Dooren ,  Verónica Rojas De La Parra ,  Arnaud Marchand ,  Sara Alassia ,  Amuri Kilonda ,  Patrick Chaltin

    发明人： Gerard Griffioen ,  Tom Van Dooren ,  Verónica Rojas De La Parra ,  Arnaud Marchand ,  Sara Alassia ,  Amuri Kilonda ,  Patrick Chaltin

    IPC分类号： C07D209/18 ,  C07D409/12 ,  C07D401/12

    CPC分类号： C07D209/18 ,  C07D209/14 ,  C07D401/12 ,  C07D409/12 ,  C07D471/04

    摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R1, R2, R4, R5, R6, E, n, Y1, Y2, Y3, Y4, Y5, B, R8, and m are as defined in the claims.

    摘要翻译： 本发明提供新的化合物和用作药物的新化合物，更特别是用于预防或治疗神经变性疾病，更具体地说是某些神经系统疾病，例如统称为tau蛋白病的病症，以及细胞毒性α-突触核蛋白淀粉样变性特征的病症 。 本发明还涉及所述新化合物在制备可用于治疗这种神经变性疾病的药物中的用途。 本发明还涉及包含所述新化合物的药物组合物和制备所述新化合物的方法。 化合物具有式（A1），其中R1，R2，R4，R5，R6，E，n，Y1，Y2，Y3，Y4，Y5，B，R8和m如权利要求中所定义。