公开(公告)号：US20070226241A1

公开(公告)日：2007-09-27

申请号：US11095443

申请日：2005-03-30

Applicant: Bobby Ng ,  Matthew Grumbach ,  Alex Warshavsky ,  Ashwin Kashyap ,  Patrick Lu ,  Che Chang ,  Wenzhi Lai ,  Peklui Cheng

Inventor： Bobby Ng ,  Matthew Grumbach ,  Alex Warshavsky ,  Ashwin Kashyap ,  Patrick Lu ,  Che Chang ,  Wenzhi Lai ,  Peklui Cheng

IPC: G06F7/00

CPC classification number: G06F17/3056 ,  G06F17/30893 ,  Y10S707/99943 ,  Y10S707/99944 ,  Y10S707/99945

Abstract: Systems and methods for generating a custom application are disclosed. In one embodiment, a request to generate an application for modifying a database may be received. In response to the request, the application may be generated based on a previously defined view of another database, e.g. a repository containing metadata describing the database. Services (e.g. network services) may be validating and files (e.g. sample server pages, library files and instructional files) may be generated for customization.

Abstract translation: 公开了用于生成定制应用的系统和方法。 在一个实施例中，可以接收生成用于修改数据库的应用的请求。 响应于该请求，可以基于先前定义的另一个数据库的视图来生成应用，例如， 包含描述数据库的元数据的存储库。 服务（例如，网络服务）可以是有效的，并且可以生成用于定制的文件（例如，样本服务器页面，库文件和指令文件）。

公开(公告)号：US20060211637A1

公开(公告)日：2006-09-21

申请号：US10523714

申请日：2003-08-06

Applicant: Puthupparampil Scaria ,  Martin Woodle ,  Patrick Lu ,  Qingquan Tang ,  Jun Xu ,  Frank Xie

Inventor： Puthupparampil Scaria ,  Martin Woodle ,  Patrick Lu ,  Qingquan Tang ,  Jun Xu ,  Frank Xie

IPC: A61K48/00 ,  C12N15/87 ,  C08L89/00

CPC classification number: A61K48/00 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2310/53 ,  C12N2320/32

Abstract: Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.

Abstract translation: 提供了通过RNA干扰在体内下调靶基因表达的方法和组合物。 该方法可用于基于基因的药物开发和人类疾病治疗的靶发现和验证。

公开(公告)号：US20240232078A1

公开(公告)日：2024-07-11

申请号：US18399553

申请日：2023-12-28

Applicant: Andrew J. HERDRICH ,  Priya AUTEE ,  Abhishek KHADE ,  Patrick LU ,  Edwin VERPLANKE ,  Vivekananthan SANJEEPAN

Inventor： Andrew J. HERDRICH ,  Priya AUTEE ,  Abhishek KHADE ,  Patrick LU ,  Edwin VERPLANKE ,  Vivekananthan SANJEEPAN

IPC: G06F12/0802

CPC classification number: G06F12/0802 ,  G06F2212/681

Abstract: Examples provide an application program interface or manner of negotiating locking or pinning or unlocking or unpinning of a cache region by which an application, software, or hardware. A cache region can be part of a level-1, level-2, lower or last level cache (LLC), or translation lookaside buffer (TLB) are locked (e.g., pinned) or unlocked (e.g., unpinned). A cache lock controller can respond to a request to lock or unlock a region of cache or TLB by indicating that the request is successful or not successful. If a request is not successful, the controller can provide feedback indicating one or more aspects of the request that are not permitted. The application, software, or hardware can submit another request, a modified request, based on the feedback to attempt to lock a portion of the cache or TLB.

公开(公告)号：US20070237718A1

公开(公告)日：2007-10-11

申请号：US11717603

申请日：2007-03-12

Applicant: Patrick Lu ,  Puthupparampil Scaria ,  Martin Woodle

Inventor： Patrick Lu ,  Puthupparampil Scaria ,  Martin Woodle

IPC: G01N33/48 ,  C12Q1/00 ,  C12Q1/68

CPC classification number: G01N33/6803 ,  C12Q1/6886 ,  G01N33/5088 ,  G01N33/574

Abstract: The present invention embodies a multi-disciplinary approach to validate or identify targets involved in any given biological process or pathway, such as an immune response, or progression or regression of disease. By introducing a target(s) with, e.g., gene delivery vector(s) or other foreign substance(s) to an in vivo system and by integrating, for example, pathological, pharmacological, bioassay, microarray and bioinformatics data obtained from the in vivo system, the present inventors are able to (1) identify one or more targets, e.g., genes, that are involved in a biological pathway of interest, (2) implement these identified targets for further analysis of the biological process or pathway and (3) provide a scalable approach in vivo for potential large quantities of target(s) discovery and validation. This process can be used in any number of applications, including the identification of agonists and antagonists to a biological process or pathway, which can lead to drugs and vaccine discovery.

Abstract translation: 本发明体现了一种多学科方法来验证或鉴定涉及任何给定生物过程或途径（例如免疫应答或疾病进展或消退）的靶标。 通过将诸如基因递送载体或其他外来物质的靶引入体内系统，并通过整合例如病理学，药理学，生物测定，微阵列和生物信息学数据，从 本发明人能够（1）识别涉及生物学途径的一个或多个目标，例如基因，（2）实施这些鉴定的目标以进一步分析生物过程或途径和（ 3）为潜在的大量目标发现和验证在体内提供可扩展的方法。 该方法可用于任何数量的应用，包括鉴定可导致药物和疫苗发现的生物过程或途径的激动剂和拮抗剂。

公开(公告)号：US20070219118A1

公开(公告)日：2007-09-20

申请号：US11591611

申请日：2006-11-02

Applicant: Patrick Lu ,  Puthupparampil Scaria ,  Martin Woodle ,  Frank Xie ,  Jun Xu ,  Quinn Tang

Inventor： Patrick Lu ,  Puthupparampil Scaria ,  Martin Woodle ,  Frank Xie ,  Jun Xu ,  Quinn Tang

IPC: A61K31/7052 ,  A61K38/00

CPC classification number: A61K48/0041 ,  A61K48/0008 ,  A61K48/0083 ,  A61K48/0091

Abstract: It has been found that certain synthetic vectors and nucleic acid sequences that encode viral genomic sequences can, for example, be administered to a subject repeatedly as a vehicle for effectively delivering one or more therapeutic nucleic acid molecules or polypeptides to a cell or tissue. Accordingly, the disclosed nucleic acid delivery vehicles can be used, for instance, as part of a therapeutic regimen that involves an ongoing use of a therapeutic nucleic acid molecule or polypeptide.

Abstract translation: 已经发现，编码病毒基因组序列的某些合成载体和核酸序列可以例如作为用于有效地将一种或多种治疗性核酸分子或多肽有效递送至细胞或组织的载体重复施用于受试者。 因此，所公开的核酸递送载体可用于例如涉及正在使用治疗性核酸分子或多肽的治疗方案的一部分。

公开(公告)号：US20190303162A1

公开(公告)日：2019-10-03

申请号：US15940408

申请日：2018-03-29

Applicant: Christopher Wilkerson ,  Binh Pham ,  Patrick Lu ,  Jared Warner Stark, IV

Inventor： Christopher Wilkerson ,  Binh Pham ,  Patrick Lu ,  Jared Warner Stark, IV

IPC: G06F9/38 ,  G06F9/30

Abstract: In an embodiment, a processor includes a branch prediction circuit and a plurality of processing engines. The branch prediction circuit is to: detect a coherence operation associated with a first memory address; identify a first branch instruction associated with the first memory address; and predict a direction for the identified branch instruction based on the detected coherence operation. Other embodiments are described and claimed.

公开(公告)号：US20090069257A1

公开(公告)日：2009-03-12

申请号：US11732158

申请日：2007-04-02

Applicant: David Ennist ,  Patrick Lu ,  Mervat Mina

Inventor： David Ennist ,  Patrick Lu ,  Mervat Mina

IPC: A61K31/711 ,  C12N15/64 ,  A61P25/00

CPC classification number: C12N15/87 ,  A61K48/0075 ,  A61K48/0083

Abstract: Non-inflammatory vector compositions are provided that are suitable for repeated transgene delivery and that result in persistent transgene expression. The compositions are non-inflammatory, the present compositions are suitable for readministration and do not induce expression-limiting immune or inflammatory responses. Thus, these compositions are useful in methods of repeated administration to achieve persistent transgene expression, and are especially suited to treating genetic, acquired and inflammation-associated conditions.

Abstract translation: 提供非炎症载体组合物，其适用于重复的转基因递送，并导致持续的转基因表达。 组合物是非炎性的，本发明的组合物适用于再次给药并且不诱导表达限制性免疫或炎症反应。 因此，这些组合物可用于重复施用以实现持续转基因表达的方法，并且特别适合于治疗遗传，获得性和炎症相关病症。

公开(公告)号：US20180089044A1

公开(公告)日：2018-03-29

申请号：US15277522

申请日：2016-09-27

Applicant: Francesc Guim Bernat ,  Karthik Kumar ,  Thomas Willhalm ,  Patrick Lu ,  Daniel Rivas Barragan

Inventor： Francesc Guim Bernat ,  Karthik Kumar ,  Thomas Willhalm ,  Patrick Lu ,  Daniel Rivas Barragan

IPC: G06F11/20 ,  G06F12/14

Abstract: Technologies for providing network interface support for remote memory and storage failover protection include a compute node. The compute node includes a memory to store one or more protected resources and a network interface. The network interface is to receive, from a requestor node in communication with the compute node, a request to access one of the protected resources. The request identifies the protected resource by a memory address. Additionally, the network interface is to determine an identity of the requestor node and determine, as a function of the identity and permissions data associated with the memory address, whether the requestor node has permission to access the protected resource. Other embodiments are described and claimed.

公开(公告)号：US08691781B2

公开(公告)日：2014-04-08

申请号：US11792179

申请日：2005-11-04

Applicant: Qingquan Tang ,  Patrick Lu ,  Martin Woodle ,  Bojian Zheng

Inventor： Qingquan Tang ,  Patrick Lu ,  Martin Woodle ,  Bojian Zheng

IPC: A01N43/04 ,  C12Q1/68 ,  C12N15/58 ,  C07H21/02 ,  C07H21/04

CPC classification number: A61K31/711 ,  A61K31/7105 ,  C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2760/16111 ,  C12N2760/18511

Abstract: The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.

Abstract translation: 本发明提供干扰呼吸道病毒感染（包括呼吸道合胞病毒和禽流感A）包括H5N1毒株在内的病毒复制的siRNA组合物。 本发明还提供siRNA组合物用于抑制呼吸道病毒感染细胞中病毒基因表达的用途，以及用于治疗受试者中的呼吸道病毒感染的用途。 本发明通常提供多核苷酸，其包含15至30个碱基的第一核苷酸序列，其靶向呼吸道合胞病毒或甲型流感病毒的基因组，其补体，双链多核苷酸或发夹多核苷酸。 另外，本发明提供了含有siRNA序列的载体，细胞和药物组合物。

公开(公告)号：US07603375B2

公开(公告)日：2009-10-13

申请号：US11095443

申请日：2005-03-30

Applicant: Bobby Ng ,  Matthew Grumbach ,  Alex Warshavsky ,  Ashwin Kashyap ,  Patrick Lu ,  Rita Chang ,  Wenzhi Lai ,  Peklui Cheng

Inventor： Bobby Ng ,  Matthew Grumbach ,  Alex Warshavsky ,  Ashwin Kashyap ,  Patrick Lu ,  Rita Chang ,  Wenzhi Lai ,  Peklui Cheng

IPC: G06F17/30

CPC classification number: G06F17/3056 ,  G06F17/30893 ,  Y10S707/99943 ,  Y10S707/99944 ,  Y10S707/99945

Abstract: Systems and methods for generating a custom application are disclosed. In one embodiment, a request to generate an application for modifying a database may be received. In response to the request, the application may be generated based on a previously defined view of another database, e.g. a repository containing metadata describing the database. Services (e.g. network services) may be validated and files (e.g. sample server pages, library files and instructional files) may be generated for customization.

Abstract translation: 公开了用于生成定制应用的系统和方法。 在一个实施例中，可以接收生成用于修改数据库的应用的请求。 响应于该请求，可以基于先前定义的另一个数据库的视图来生成应用，例如， 包含描述数据库的元数据的存储库。 可以验证服务（例如网络服务），并且可以生成用于定制的文件（例如，样本服务器页面，库文件和说明文件）。