公开(公告)号：US06510780B1

公开(公告)日：2003-01-28

申请号：US09857507

申请日：2001-08-03

申请人： Bruce Eden ,  David Mantle ,  David Williams ,  Paul Britton

发明人： Bruce Eden ,  David Mantle ,  David Williams ,  Paul Britton

IPC分类号： F04B902

CPC分类号： F04B9/02 ,  F04B11/0083 ,  F15B7/005 ,  F15B7/08

摘要： A reversibly actuatable fluid hydraulic pump is described for use in a hydraulically driven elevator. The pump comprises a cylinder and a piston linearly actuatable within the cylinder by a ball screw race disposed over a spindle and connected to the piston. The shaft of the piston is hollow to receive the spindle as the piston is drawn along by virtue of the motion of the race along the spindle, and seals are provided at the free end of the piston which sealingly engage against the walls of the cylinder, and on the cylinder which sealingly engage with the shaft of the piston. A further feature of the invention is the provision of a compressible gas between the end of the cylinder and the end of the piston so that the expansion thereof reduces the work required to move the piston out of the cylinder, whereas when the system is relaxing, the compressible gas provides extra resistance and thus a smoother motion.

摘要翻译： 描述了用于液压驱动的电梯中的可逆驱动的液压泵。 该泵包括一气缸和一活塞，可通过设置在主轴上并与活塞连接的滚珠丝杠，在气缸内可直线致动。 当活塞沿着主轴沿着座圈的运动而被拉动时，活塞的轴是中空的以容纳主轴，并且密封件设置在活塞的自由端处，密封地与气缸壁相接合， 并且在与活塞的轴密封地接合的气缸上。 本发明的另一个特征是在气缸的端部和活塞的端部之间提供可压缩气体，使得其膨胀减小了将活塞移出气缸所需的工作，而当系统松弛时， 可压缩气体提供额外的阻力，从而提供更平滑的运动。

公开(公告)号：US20120177675A1

公开(公告)日：2012-07-12

申请号：US13382119

申请日：2010-07-05

申请人： Paul Britton ,  Erica Bickerton ,  Maria Armesto

发明人： Paul Britton ,  Erica Bickerton ,  Maria Armesto

IPC分类号： A61K39/215 ,  C12N15/50 ,  A61P31/14 ,  C12N5/071 ,  C12N15/85 ,  C12N7/01 ,  C12N7/02 ,  C07K7/06 ,  A61P31/16

CPC分类号： C07K14/005 ,  A61K2039/525 ,  C07K2319/74 ,  C12N2770/20022

摘要： The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.

摘要翻译： 本发明提供了一种嵌合型冠状病毒S蛋白，其基于来自具有限制性组织嗜性的冠状病毒株的S蛋白，但其包含具有延长的组织嗜性的冠状病毒株的至少部分S2亚基，使得包含 嵌合体S蛋白具有延长的组织向性。 本发明还提供了包含这种嵌合S蛋白的病毒。

公开(公告)号：US07445785B2

公开(公告)日：2008-11-04

申请号：US10547219

申请日：2004-03-03

申请人： David Cavanagh ,  Paul Britton ,  Ian Tarpey

发明人： David Cavanagh ,  Paul Britton ,  Ian Tarpey

IPC分类号： A61K39/215 ,  C07K14/165

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.

摘要翻译： 本发明提供了一种用于保护家禽的感染性支气管炎的疫苗，其包含减毒的感染性支气管炎病毒（IBV）和药物可接受的载体或稀释剂，其特征在于所述减毒的IBV包含异源穗基因。 这种疫苗基于能够表达从不同IBV毒株衍生的尖峰的IBV菌株Beaudette。 本发明提供的疫苗也允许通过卵内途径给药。

公开(公告)号：US08828407B2

公开(公告)日：2014-09-09

申请号：US13382119

申请日：2010-07-05

申请人： Paul Britton ,  Erica Bickerton ,  Maria Armesto

发明人： Paul Britton ,  Erica Bickerton ,  Maria Armesto

IPC分类号： A61K39/215 ,  C12N7/01 ,  C12N7/02 ,  C12N5/10 ,  C12N15/50 ,  C07K19/00 ,  C07K14/165

CPC分类号： C07K14/005 ,  A61K2039/525 ,  C07K2319/74 ,  C12N2770/20022

摘要： The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.

摘要翻译： 本发明提供了一种嵌合型冠状病毒S蛋白，其基于来自具有限制性组织嗜性的冠状病毒株的S蛋白，但其包含具有延长的组织嗜性的冠状病毒株的至少部分S2亚基，使得包含 嵌合体S蛋白具有延长的组织向性。 本发明还提供了包含这种嵌合S蛋白的病毒。

公开(公告)号：US20070154489A1

公开(公告)日：2007-07-05

申请号：US10547219

申请日：2004-03-03

申请人： David Cavanagh ,  Paul Britton ,  Ian Tarpey

发明人： David Cavanagh ,  Paul Britton ,  Ian Tarpey

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.

摘要翻译： 本发明提供了一种用于保护家禽的感染性支气管炎的疫苗，其包含减毒的感染性支气管炎病毒（IBV）和药物可接受的载体或稀释剂，其特征在于所述减毒的IBV包含异源穗基因。 这种疫苗基于能够表达从不同IBV毒株衍生的尖峰的IBV菌株Beaudette。 本发明提供的疫苗也允许通过卵内途径给药。