公开(公告)号：US07563862B2

公开(公告)日：2009-07-21

申请号：US10976699

申请日：2004-10-29

申请人： Frank Sieg ,  Paul Edmund Hughes ,  Thorsten Gorba

发明人： Frank Sieg ,  Paul Edmund Hughes ,  Thorsten Gorba

IPC分类号： C07K7/00 ,  C07K7/08 ,  C07K7/04 ,  C12N5/00 ,  C12N5/02 ,  C12N5/06 ,  C12N5/08 ,  A61K38/00 ,  G01N33/567

CPC分类号： A61K38/17 ,  A61K48/00 ,  C07H21/04 ,  C07K14/705 ,  C12Q1/68

摘要： The invention discloses a family of peptides termed NRP compounds or NRPs that can promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation and/or neuronal survival, and provides compositions and methods for the use of NRPs in the treatment of brain injury and neurodegenerative disease. NRP compounds can induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as exposure to toxins, stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient. NRP compounds can be formulated into pharmaceutically acceptable dose forms for therapeutic use. Methods for detecting neural regeneration, neural proliferation, neural differentiation, neurite outgrowth and neural survival can be used to develop other neurally active agents.

摘要翻译： 本发明公开了一种称为NRP化合物或NRP的肽，可以促进神经元迁移，神经突生长，神经元增殖，神经分化和/或神经元存活，并提供使用NRP治疗脑损伤和神经变性的组合物和方法 疾病。 NRP化合物可以诱导神经元和成神经细胞增殖并迁移到由急性脑损伤或慢性神经变性疾病（例如暴露于毒素，中风，创伤，神经系统感染，脱髓鞘疾病，痴呆和代谢性疾病）引起的损伤区域中。 NRP化合物可以通过包括口服，腹膜内，血管内和直接进入患者的神经系统的多种方式直接施用于受试者或受试者的细胞。 NRP化合物可以配制成用于治疗用途的药学上可接受的剂型。 用于检测神经再生，神经增生，神经分化，神经突生长和神经存活的方法可用于开发其他神经活性剂。