公开(公告)号：US20150112183A1

公开(公告)日：2015-04-23

申请号：US14310721

申请日：2014-06-20

申请人： James Peacock, III ,  John Patrick Claude ,  Paul Henry Kane ,  Jeffrey C. Lotz

发明人： James Peacock, III ,  John Patrick Claude ,  Paul Henry Kane ,  Jeffrey C. Lotz

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/407 ,  A61B5/4514 ,  A61B5/4824 ,  A61B5/7203 ,  G01R33/34069 ,  G01R33/3415 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/565 ,  G01R33/56527 ,  G06F19/00

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

公开(公告)号：US20240324892A1

公开(公告)日：2024-10-03

申请号：US18501441

申请日：2023-11-03

申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01R33/485

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/748 ,  G01R33/485 ,  A61B5/743 ,  A61B2576/02

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

公开(公告)号：US08825131B2

公开(公告)日：2014-09-02

申请号：US13444731

申请日：2012-04-11

申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4566 ,  A61B5/4824 ,  A61B5/743 ,  A61B5/748 ,  A61B2576/02 ,  G01R33/485

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并且被配置为通过自动化系统来优化信噪比，所述自动系统选择性地进行最佳信道选择，相位和频率校正以及帧编辑 一个给定的收购系列。 诊断处理器基于使用从获得和处理的MRS谱中提取的MRS数据的加权因子集来计算盘的诊断值，所述MRS数据已经与疼痛与非痛苦的盘相关联的多种化学物质。 显示器提供用于分析的光盘作为腰椎MRI图像上的覆盖物的结果的指示。

公开(公告)号：US08761860B2

公开(公告)日：2014-06-24

申请号：US12579371

申请日：2009-10-14

申请人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/407 ,  A61B5/4514 ,  A61B5/4824 ,  A61B5/7203 ,  G01R33/34069 ,  G01R33/3415 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/565 ,  G01R33/56527 ,  G06F19/00

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。