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1.发明申请公开(公告)号：US20060053504A1
公开(公告)日：2006-03-09
申请号：US10524089
申请日：2003-08-11
申请人： Lei Zhu , Peggy Winters-Digiacinto , Robert Etches
发明人： Lei Zhu , Peggy Winters-Digiacinto , Robert Etches
IPC分类号： A01K67/027 , A61K35/54
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/02 , C07K16/44 , C07K2317/21 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/60 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.
摘要翻译： 编码外源蛋白的转基因稳定整合到胚胎干细胞中，并存在于转基因或嵌合鸟类的体细胞组织中。 转基因编码外源蛋白，并在内胚层，外胚层，中胚层或额外的胚胎组织中表达。 通过相应地选择转基因的内容来提供组织特异性。 基因组由转基因外源DNA组成的转基因鸟类表达具有组织特异性的外源蛋白质，并特异性表达输卵管细胞中的外源蛋白质，以将外源蛋白质浓缩在蛋清中。
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2.发明授权公开(公告)号：US07323618B2
公开(公告)日：2008-01-29
申请号：US10216098
申请日：2002-08-09
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/02 , C07K16/44 , C07K2317/21 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/60 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.
摘要翻译： 编码外源蛋白的转基因稳定整合到胚胎干细胞中，并存在于转基因或嵌合鸟的体细胞组织中。 转基因编码外源蛋白，并在内胚层，外胚层，中胚层或额外的胚胎组织中表达。 通过选择转基因的含量来提供组织特异性。 基因组由转基因外源DNA组成的转基因鸟类表达具有组织特异性的外源蛋白，并特异性表达输卵管细胞中的外源蛋白，以将外源蛋白浓缩在蛋清中。
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3.发明申请公开(公告)号：US20090165155A1
公开(公告)日：2009-06-25
申请号：US12105231
申请日：2008-04-17
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/30 , A01K2267/01 , C07K16/02 , C07K16/44 , C07K2317/21 , C12N15/8509 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.
摘要翻译： 编码外源蛋白的转基因稳定整合到胚胎干细胞中，并存在于转基因或嵌合鸟类的体细胞组织中。 转基因编码外源蛋白，并在内胚层，外胚层，中胚层或额外的胚胎组织中表达。 通过选择转基因的含量来提供组织特异性。 基因组由转基因外源DNA组成的转基因鸟类表达具有组织特异性的外源蛋白，并特异性表达输卵管细胞中的外源蛋白，以将外源蛋白浓缩在蛋清中。
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