公开(公告)号：US20060154976A1

公开(公告)日：2006-07-13

申请号：US11375836

申请日：2006-03-15

申请人： Peter Boehm ,  Wolf Meinicke ,  Axel Riedel

发明人： Peter Boehm ,  Wolf Meinicke ,  Axel Riedel

IPC分类号： A61K31/4184 ,  A61K31/401

CPC分类号： A61K31/522 ,  A61K31/401 ,  A61K31/403 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/675 ,  A61K38/556 ,  A61K45/06 ,  A61K2300/00

摘要： A method of treatment of indications which can be positively influenced by inhibition of AT1 mediated effects with maintenance of AT2 receptor mediated effects of angiotensin II and by ACE inhibition, thus also increasing bradykinin mediated effects, e.g., to reduce the incidence of stroke, acute myocardial infarction or cardiovascular death, or of indications associated with the increase of AT1 receptors in the subepithelial area or increase of AT2 receptors in the epithelia, comprising coadministration of effective amounts of an angiotensin II antagonist and an ACE inhibitor, pharmaceutical compositions containing an angiotensin II antagonist together with an ACE inhibitor and the use of an angiotensin II antagonist and an ACE inhibitor for the manufacture of corresponding pharmaceutical compositions.

摘要翻译： 一种治疗适应症的方法，其可以通过维持AT2受体介导的血管紧张素II的作用和通过ACE抑制来抑制AT 1介导的作用而受到积极的影响，因此也 增加缓激肽介导的作用，例如降低卒中发生率，急性心肌梗死或心血管死亡，或与上皮下区域中的AT 1受体增加有关的适应症或AT < 包括共同施用有效量的血管紧张素II拮抗剂和ACE抑制剂，含有血管紧张素II拮抗剂和ACE抑制剂的药物组合物，以及使用血管紧张素II拮抗剂和ACE抑制剂 制造相应的药物组合物。

公开(公告)号：US4970940A

公开(公告)日：1990-11-20

申请号：US421048

申请日：1988-10-22

申请人： Peter Boehm ,  Wilfried Wagner ,  Kai-Michael Graichen ,  Ralf Jakobi

发明人： Peter Boehm ,  Wilfried Wagner ,  Kai-Michael Graichen ,  Ralf Jakobi

IPC分类号： B60T13/57 ,  B60T13/569 ,  B60T13/573

CPC分类号： B60T13/569

摘要： A vacuum brake booster in which the guiding sleeve (14) for the push rod (29) has an annular ring which defines a cylindrical guiding surface (22) and is guided, in axial movements of the guiding sleeve, by a guide bore in the housing (10) of the control valve.

摘要翻译： 一种真空制动助力器，其中用于推杆（29）的引导套筒（14）具有限定圆柱形引导表面（22）的环形环，并且在引导套筒的轴向运动中被导向孔引导 控制阀的外壳（10）。

公开(公告)号：US4641568A

公开(公告)日：1987-02-10

申请号：US710926

申请日：1985-03-12

申请人： Peter Boehm ,  Peter Volz ,  Gilbert Bischoff ,  Sigmund Booten ,  Klaus Engert ,  Albin Loew

发明人： Peter Boehm ,  Peter Volz ,  Gilbert Bischoff ,  Sigmund Booten ,  Klaus Engert ,  Albin Loew

IPC分类号： B60T13/56 ,  B60T13/569 ,  F15B9/10

CPC分类号： B60T13/569

摘要： A vacuum-operated brake power booster is provided having a movable wall which is sealed off relative to the vacuum housing and a control valve body which is slidable jointly with the movable wall. A hollow cylinder-shaped expanded plastic ring is arranged in the annular clearance between the neck portion of the pedal side housing shell and the collar of the diaphragm, which collar sealingly surrounds the control valve body. The expanded plastic ring effects the air flow during brake operation such that the air flow, enters the annular clearance through the duct extending in a radial direction within the control valve body and is suitably deflected and cushioned so that no noises arise at this point. In the same manner and simultaneously, vibrations, especially those of the neck portion of the housing shell of the vacuum housing, are suppressed, since the expanded plastic ring adheres to the inside wall of the housing shell.

摘要翻译： 提供了一种真空操作的制动助力器，其具有相对于真空壳体密封的可动壁和与可动壁联合滑动的控制阀体。 在踏板侧壳体壳体的颈部和隔膜的轴环之间的环形间隙中布置有中空的圆柱形膨胀塑料环，该环形件密封地围绕控制阀体。 膨胀的塑料环在制动操作期间影响空气流动，使得空气流通过在控制阀体内沿径向方向延伸的管道进入环形间隙，并且适当地偏转和缓冲，使得在这一点上不产生噪声。 以相同的方式同时，由于膨胀的塑料环粘附到壳体壳体的内壁，振动，特别是真空壳体的壳体壳体的颈部的振动被抑制。

公开(公告)号：US4520007A

公开(公告)日：1985-05-28

申请号：US504348

申请日：1983-06-14

申请人： Ian D. Entwistle ,  Peter Boehm

发明人： Ian D. Entwistle ,  Peter Boehm

IPC分类号： C07D311/56 ,  C07D405/08 ,  C07D405/10 ,  C07D405/12 ,  C07D407/08 ,  A01N43/16 ,  A01N25/00 ,  A01N25/08

CPC分类号： C07D405/08 ,  C07D311/56 ,  C07D405/10 ,  C07D405/12 ,  C07D407/08 ,  Y10S514/822

摘要： Compounds having blood-anticoagulant properties of the general molecular formula: ##STR1## in which Z represents a halogen atom, preferably a chlorine atom, and n is 0, 1 or 2 and R.sup.4 represents either (1) a grouping which comprises a phenylene radical attached directly or indirectly to the tetralin ring and having in the para position (with respect to such attachment) an electron-withdrawing atom or group whose rotational volume substantially does not exceed that of a phenyl group and which forms together with said phenylene radical a polarizable structure, or (2) a grouping selected from: ##STR2## or (3) a grouping which comprises a phenylene radical attached directly to the tetralin ring and having in the para position (with respect to such attachment) a substituted furanyl or thiophenyl radical attached thereto directly or through oxygen and/or methylene, said furanyl or thiophenyl radical having such an electron-withdrawing atom or group as a substituent in a position forming with the furanyl or thiophenyl radical a polarizable structure, compounds of the type (1) in which R.sup.4 contains two phenylene radicals linked essentially linearly by an aliphatic chain comprising a methylene radical or radicals and optionally at least one oxygen or sulphur atom being preferred.Also included are the processes for the preparation of such compound; rodenticidal compositions containing them; and a method for controlling rodents by applying such a composition.

摘要翻译： 具有以下通式的抗凝血性的化合物：其中Z表示卤素原子，优选氯原子，n为0,1或2，R4表示（1）包括 直接或间接连接到四氢化萘环上并具有对位（相对于这种连接）的亚苯基，其旋转体积基本上不超过苯基的吸电子原子或基团，并与所述亚苯基一起形成 基团可极化结构，或（2）选自以下的分组： + TR 或（3）包含直接连接到四氢萘环并具有对位（相对于其的位置）的亚苯基的分组 连接）直接或通过氧和/或亚甲基与其连接的取代的呋喃基或硫代苯基，所述呋喃基或噻吩基具有这样的吸电子原子或基团作为取代基 n与呋喃基或硫代苯基形成可极化结构，其中R4包含两个亚苯基的化合物，其中包含基本上由包含亚甲基或基团的脂族链和任选的至少一个氧或硫原子线性连接的亚苯基 。 还包括制备这种化合物的方法; 含有它们的杀鼠剂组合物; 以及通过应用这种组合物来控制啮齿动物的方法。

公开(公告)号：US20080146639A1

公开(公告)日：2008-06-19

申请号：US12035166

申请日：2008-02-21

申请人： Peter BOEHM ,  Wolf Thomas MEINICKE ,  Axel RIEDEL

发明人： Peter BOEHM ,  Wolf Thomas MEINICKE ,  Axel RIEDEL

IPC分类号： A61K31/4184 ,  A61P9/00 ,  A61P7/00

CPC分类号： A61K31/522 ,  A61K31/401 ,  A61K31/403 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/675 ,  A61K38/556 ,  A61K45/06 ,  A61K2300/00

摘要： A method of treatment of indications which can be positively influenced by inhibition of AT1 mediated effects with maintenance of AT2 receptor mediated effects of angiotensin II and by ACE inhibition, thus also increasing bradykinin mediated effects, e.g., to reduce the incidence of stroke, acute myocardial infarction or cardiovascular death, or of indications associated with the increase of AT1 receptors in the subepithelial area or increase of AT2 receptors in the epithelia, comprising coadministration of effective amounts of an angiotensin II antagonist and an ACE inhibitor, pharmaceutical compositions containing an angiotensin II antagonist together with an ACE inhibitor and the use of an angiotensin II antagonist and an ACE inhibitor for the manufacture of corresponding pharmaceutical compositions.

摘要翻译： 一种治疗适应症的方法，其可以通过维持AT2受体介导的血管紧张素II的作用和通过ACE抑制来抑制AT 1介导的作用而受到积极的影响，因此也 增加缓激肽介导的作用，例如降低卒中发生率，急性心肌梗死或心血管死亡，或与上皮下区域中的AT 1受体增加有关的适应症或AT < 包括共同施用有效量的血管紧张素II拮抗剂和ACE抑制剂，含有血管紧张素II拮抗剂和ACE抑制剂的药物组合物，以及使用血管紧张素II拮抗剂和ACE抑制剂 制造相应的药物组合物。

公开(公告)号：US5095805A

公开(公告)日：1992-03-17

申请号：US518903

申请日：1990-05-04

申请人： Peter Boehm ,  Wilfried Wagner ,  Manfred Rueffer ,  Bernd Toepperwien

发明人： Peter Boehm ,  Wilfried Wagner ,  Manfred Rueffer ,  Bernd Toepperwien

IPC分类号： B60T13/52 ,  B60T13/57

CPC分类号： B60T13/57 ,  Y10T137/86919

摘要： A vacuum brake power booster, in particular for motor vehicles, which includes a poppet valve (12) sealing two valve seats (18, 19) and which is axially deformable within the area of a rolling fold (15) also includes an annular part which is either mounted on the outside of the rolling fold (15) in a form-fit manner or arranged inside the elastic material (24) of the poppet valve (12). This annular part prevents the rolling fold (15) from being blown up outwardly due to the pressure differential prevailing between its two sides so that it will be possible to reduce the return force and thus also the response force.

摘要翻译： 一种特别是用于机动车辆的真空制动器助力器，其包括密封两个阀座（18,19）的提升阀（12），其在滚动折叠（15）的区域内可轴向变形，还包括环形部分 或者以形状配合的方式安装在折边（15）的外侧，或者布置在提升阀（12）的弹性材料（24）的内部。 这个环形部分防止了由于其两侧之间的压力差而向外吹出卷边（15），使得可以减小返回力并因此降低响应力。

公开(公告)号：US5031971A

公开(公告)日：1991-07-16

申请号：US359888

申请日：1989-06-01

申请人： Peter Boehm ,  Wilfried Wagner ,  Lothar Schiel ,  Hans-Juergen Beilfuss

发明人： Peter Boehm ,  Wilfried Wagner ,  Lothar Schiel ,  Hans-Juergen Beilfuss

IPC分类号： B60T8/175 ,  B60T8/44 ,  B60T8/48 ,  B60T13/56 ,  B60T13/563 ,  B60T13/569 ,  B60T13/573 ,  F16D65/28

CPC分类号： B60T8/449 ,  B60T13/563 ,  B60T13/569 ,  B60T13/573 ,  B60T8/4854

摘要： As an improvement on conventional brake systems of the type having a multiple-chamber vacuum brake force booster, a modification is disclosed to the effect that, in the brake releasing position, there is a pressure medium communication between a booster chamber and a simulator chamber. A modulator chamber requires only one external connection, thereby substantially simplifying the construction of the brake force booster and readily permitting an extension of the system's use to include traction slip control.

摘要翻译： 作为具有多室真空制动力助力器的常规制动系统的改进，公开了一种修改，即在制动器释放位置中，在增压室和模拟器室之间存在压力介质连通。 调制器室仅需要一个外部连接，从而大大简化了制动力增强器的结构，并且容易地允许系统的使用延伸以包括牵引滑动控制。

公开(公告)号：US5005465A

公开(公告)日：1991-04-09

申请号：US313922

申请日：1989-02-22

申请人： Peter Boehm ,  Ralf Jakobi ,  Jurgen Bauer

发明人： Peter Boehm ,  Ralf Jakobi ,  Jurgen Bauer

IPC分类号： B60T13/56 ,  B60T13/52

CPC分类号： B60T13/52

摘要： In order to enable a brake booster to operate both with a pressure above atmospheric and with atmospheric pressure without any negative mutual influences of the two energy types and without any change in the responding behavior of the device in case of failure of either energy type, the invention provides a pneumatic system which, during the operation of the brake booster with pressure above atmospheric, causes a force constituent to become active so as to counteract the forces caused by the increased pressure difference and acting on the control valve piston as well as on the control valve housing.

摘要翻译： 为了使制动助力器能够在高于大气压和大气压力的情况下操作，而没有两种能量类型的任何负相互影响，并且在任一能量类型故障的情况下，在设备的响应行为没有任何变化的情况下， 本发明提供了一种气动系统，其在压力高于大气压的制动助力器的操作期间，使得力组分变得有效，以便抵消由增加的压力差引起的作用在控制阀活塞上的作用 控制阀外壳。

公开(公告)号：US4729289A

公开(公告)日：1988-03-08

申请号：US906563

申请日：1986-09-08

申请人： Peter Boehm

发明人： Peter Boehm

IPC分类号： B60T13/563 ,  F15B9/10

CPC分类号： B60T13/563

摘要： In a power brake booster for an automotive vehicle, with a housing (1, 2) subdivided into two compartments by a partition wall (41), the compartment close to the brake pedal contains a working chamber (25) and a vacuum chamber (33), while the compartment close to the master cylinder contains a working chamber (24) and a vacuum chamber (32), with a longitudinally slidable control housing (4) with valve device (8, 37, 38) being sealably held and guided in a central opening of the partition wall (41), the said control housing incorporating a longitudinal channel, for instance on annular gap (21) which, on the one hand, is via an opening or bore (26) in communication with the one working chamber (24), while, on the other hand, it terminates into a chamber, for example an annular chamber (20), which is connected to the valve chamber (42) behind the valve device (8, 37, 38) and which is connected to the other working chamber (25) via a cross bore (39). Through the valve device (8, 37, 38), the annular gap (21) is connected to another channel (34) which is provided in the control housing (4) and is in permanent communication with the suction port (11) so that both working chambers (24, 25) are connected both to the vacuum source and to the outside air through channels (34, 36 and 20, 19, 21, 26, 39, respectively) provided in the control housing (4).

摘要翻译： 在用于机动车辆的动力制动助力器中，通过分隔壁（41）将壳体（1,2）细分为两个隔室，靠近制动踏板的舱室包含一个工作室（25）和一个真空室（33） ），而靠近主缸的舱室包含一个具有阀装置（8,37,38）的可纵向滑动的控制壳体（4）的工作室（24）和真空室（32），该壳体可密封地保持和引导 分隔壁（41）的中心开口，所述控制壳体包括纵向通道，例如在环形间隙（21）上，所述环形间隙一方面经由与一个工作连通的开口或孔（26） 另一方面，另一方面，它终止于室，例如环形室（20），其连接到阀装置（8,37,38）后面的阀室（42），并且其中 经由十字孔（39）连接到另一个工作室（25）。 通过阀装置（8,37,38），环形间隙（21）连接到设置在控制壳体（4）中并与吸入口（11）永久连通的另一通道（34），使得 两个工作室（24,25）通过设置在控制壳体（4）中的通道（34,36和20,19,21,26,39）连接到真空源和外部空气。

公开(公告)号：US4587885A

公开(公告)日：1986-05-13

申请号：US646240

申请日：1984-08-29

申请人： Peter Boehm ,  Wilfried Wagner

发明人： Peter Boehm ,  Wilfried Wagner

IPC分类号： B60T13/57 ,  F15B9/10

CPC分类号： B60T13/57

摘要： In a vacuum-operated brake power booster, a transverse member is provided which confines the axial movability of the control piston relative to the control housing. The transverse member abuts against a bead of a rubber-elastic material, the bead forming part of the slide-guide ring sealing the booster housing relative to the control housing. The tranverse member is formed of a substantially U-shaped sheet-metal blank, with both free ends of the fork arms extending parallel to two limbs of the member. The arms are provided with hook-shaped tabs which are bendable around a pin forming part of the control housing for the purpose of fixing the transverse member in its aperture in the control housing. In order to enable a proper and easy bending of the tabs during assembly, notches are provided at the radially outside small faces or edges of the two fork arms.

摘要翻译： 在真空操作的制动助力器中，提供横向构件，其限制了控制活塞相对于控制壳体的轴向可移动性。 横向构件抵靠橡胶弹性材料的胎圈，滑动导向环的胎圈形成部分相对于控制壳体密封助力器壳体。 横向构件由大致U形的金属板坯形成，叉臂的两个自由端平行于构件的两个腿延伸。 臂设置有钩状突片，其可以围绕形成控制壳体的一部分的销弯曲，以将横向构件固定在其控制壳体中的孔中。 为了在组装期间能够适当且容易地弯曲突片，在两个叉臂的径向外侧的小面或边缘处设有凹口。