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公开(公告)号：US4997753A
公开(公告)日：1991-03-05
申请号：US393656
申请日：1989-08-14
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
CPC分类号： C12N11/02 , C12N1/00 , C12N5/0075 , C12P1/00 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US4863856A
公开(公告)日：1989-09-05
申请号：US932088
申请日：1986-11-18
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr. , Gennaro J. Maffia
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr. , Gennaro J. Maffia
CPC分类号： C12N1/00 , C12N11/02 , C12N5/0075 , C12P1/00 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US4861714A
公开(公告)日：1989-08-29
申请号：US719881
申请日：1985-04-04
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
CPC分类号： C12P1/00 , C12N1/00 , C12N11/02 , C12N5/0075 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US5100783A
公开(公告)日：1992-03-31
申请号：US333831
申请日：1989-04-05
CPC分类号： C12P1/00 , C12N1/00 , C12N11/02 , C12N5/0075 , C12N2533/54
摘要： Weighted microsponges formed of a porous, biostable matrix of a biocompatible polymer containing an inert weighing material are prepared suitable for use in culturing organisms in motive reactor systems. The matrix has an open to the surface pore structure with an average pore size in the range of from about 1 to about 150 microns and the pores occupy from about 70 to about 98% by volume of the microsponge. The microsponges have an average particle size of from about 100 to about 1000 microns and a specific gravity of above about 1.05. Biocompatible polymers that can be used are polysaccharides, proteins and synthetic polymers and the weighing material can be metals, metal alloys, metal oxides or ceramics.
摘要翻译： 制备由包含惰性称重材料的生物相容性聚合物的多孔，生物稳定基质形成的加权微球，适用于在动力反应器系统中培养生物体。 该基质具有开放的表面孔结构，平均孔径在约1至约150微米的范围内，孔隙占微球体积的约70至约98体积％。 微球的平均粒度为约100至约1000微米，比重高于约1.05。 可以使用的生物相容性聚合物是多糖，蛋白质和合成聚合物，称重材料可以是金属，金属合金，金属氧化物或陶瓷。
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