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公开(公告)号:US20090305279A1
公开(公告)日:2009-12-10
申请号:US12439278
申请日:2007-08-28
申请人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
发明人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
CPC分类号: C12Q1/6881 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要: Provided are methods, kits and arrays for use in determining whether a scar of interest is keloid or non-keloid in nature. These determine keloid or non-keloid nature based on comparison of gene expression in the scar of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is decreased in a sample representative of gene expression in the scar of interest compared to expression of the same gene (or genes) in the control sample this indicates that the scar of interest comprises a keloid.
摘要翻译: 提供了用于确定感兴趣的瘢痕是瘢痕疙瘩还是非瘢痕疙瘩的方法,试剂盒和阵列。 这些基于对照样品中感兴趣的瘢痕中的基因表达与表达的比较来确定瘢痕疙瘩或非瘢痕疙瘩性质。 与对照样品中相同基因(或基因)的表达相比,表达选自表1所示基因组中的至少一种基因的表达在表达感兴趣的瘢痕中的基因表达的样品中降低 表示感兴趣的瘢痕包括瘢痕疙瘩。
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公开(公告)号:US20100004140A1
公开(公告)日:2010-01-07
申请号:US12439322
申请日:2007-08-28
申请人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
发明人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
CPC分类号: C12Q1/6883 , C12Q1/6837 , C12Q2600/106 , C12Q2600/158
摘要: Provided are methods, kits and arrays for use in determining susceptibility to keloid formation. These determine susceptibility based on comparison of gene expression in a patient of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is increased in a sample representative of gene expression in the patient compared to expression of the same gene (or genes) in the control sample this is indicative of a susceptibility to keloid formation.
摘要翻译: 提供用于确定对瘢痕疙瘩形成的易感性的方法,试剂盒和阵列。 这些基于对照样品中表达的感兴趣患者中的基因表达的比较来确定易感性。 如果表达于表1所示基因组中的至少一种基因的表达与对照样品中相同基因(或基因)的表达相比,在代表患者基因表达的样品中表达增加,这表明 对瘢痕疙瘩形成的易感性。
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公开(公告)号:US20100184610A1
公开(公告)日:2010-07-22
申请号:US12439350
申请日:2007-08-28
申请人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
发明人: Mark William James Ferguson , Hugh Gerald Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
CPC分类号: C12Q1/6883 , C12Q1/6837 , C12Q2600/106 , C12Q2600/158
摘要: Provided are methods, kits and arrays for use in determining susceptibility to keloid formation. These determine susceptibility based on comparison of gene expression in a patient of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is decreased in a sample representative of gene expression in the patient compared to expression of the same gene (or genes) in the control sample this is indicative of a susceptibility to keloid formation.
摘要翻译: 提供用于确定对瘢痕疙瘩形成的易感性的方法,试剂盒和阵列。 这些基于对照样品中表达的感兴趣患者中的基因表达的比较来确定易感性。 如果表达于表1所示的基因组中的至少一种基因的表达与对照样品中相同基因(或基因)的表达相比,在代表患者基因表达的样品中降低,这表明 对瘢痕疙瘩形成的易感性。
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公开(公告)号:US20090280995A1
公开(公告)日:2009-11-12
申请号:US12439301
申请日:2007-08-28
申请人: Mark William James Ferguson , Hugh Gerard Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
发明人: Mark William James Ferguson , Hugh Gerard Laverty , Nicholas Occleston , Sharon O'Kane , Darren Hodgson , Neil French , Claire Cridland , Philip Roby , Ardeshir Bayat
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要: Provided are methods, kits and arrays for use in determining whether a scar of interest is keloid or non-keloid in nature. These determine keloid or non-keloid nature based on comparison of gene expression in the scar of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is increased in a sample representative of gene expression in the scar of interest compared to expression of the same gene (or genes) in the control sample this indicates that the scar of interest comprises a keloid.
摘要翻译: 提供了用于确定感兴趣的瘢痕是瘢痕疙瘩还是非瘢痕疙瘩的方法,试剂盒和阵列。 这些基于对照样品中感兴趣的瘢痕中的基因表达与表达的比较来确定瘢痕疙瘩或非瘢痕疙瘩性质。 与对照样品中相同基因(或基因)的表达相比,表达选自表1所示基因组中的至少一种基因的表达在代表感兴趣的瘢痕中的基因表达的样品中增加 表示感兴趣的瘢痕包括瘢痕疙瘩。
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