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1.发明授权Flow and volume regulated inhalation for treatment of severe oral corticosteroid-dependent asthma 有权流量和体积调节吸入治疗严重口服皮质类固醇依赖性哮喘公开(公告)号：US08834848B2
公开(公告)日：2014-09-16
申请号：US13605451
申请日：2012-09-06
CPC分类号： A61K9/0078 , A61M11/005 , A61M11/06 , A61M2016/0024 , A61M2016/0027 , A61M2205/502 , Y10S514/862 , Y10S514/958
摘要： A drug and device combination system used in a method for treatment of patients suffering from severe and oral corticosteroid-dependent asthma and other respiratory diseases requiring a treatment with orally administered steroids. The method for administration of the inhalable corticosteroid by a flow rate and volume regulated inhalation. The combination system of the inhalable corticosteroid and the device for regulating flow rate and volume of the inhalable corticosteroid and thus achieving delivery of said inhalable corticosteroid into the small airways of the lungs. The individually programmable device that assures safe and reproducible corticosteroid delivery compliant with treatment protocol.
摘要翻译： 用于治疗患有严重和口服皮质类固醇依赖性哮喘和需要口服给药的类固醇治疗的其它呼吸道疾病的患者的方法中的药物和装置组合系统。 通过流量和体积调节吸入给药可吸入皮质类固醇的方法。 可吸入皮质类固醇的组合系统和用于调节可吸入皮质类固醇的流速和体积的装置，从而实现将所述可吸入的皮质类固醇递送到肺的小气道中。 可单独编程的设备，确保符合治疗方案的安全可重复的皮质类固醇输送。
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2.发明申请Use of a Glucocorticoid Composition for the Treatment of Severe and Uncontrolled Asthma 有权使用糖皮质激素组合物治疗严重和不受控制的哮喘公开(公告)号：US20120040945A1
公开(公告)日：2012-02-16
申请号：US13147761
申请日：2010-02-03
IPC分类号： A61K31/573 , C07J5/00 , A61P11/06 , C07J3/00
CPC分类号： A61K31/573 , A61K9/0078 , A61K31/56 , A61K31/58
摘要： Methods, devices and compositions for treatment of severe and uncontrolled asthma are provided by which high amounts of an inhaled corticosteroid are directed to the small airways of the lower lungs. The invention provides for a substantial decrease in the dose of concurrently administered oral corticosteroids. A particular advantage of the invention is the significant reduction in corticosteroid-related adverse effects.
摘要翻译： 提供了用于治疗严重和不受控制的哮喘的方法，装置和组合物，其中大量的吸入性皮质类固醇被引导到下肺的小气道。 本发明提供同时施用的口服皮质类固醇的剂量的显着降低。 本发明的特别优点在于皮质类固醇相关的不利影响的显着降低。
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3.发明申请Drug and Device Combination System for Flow and Volume Regulated Inhalation and a Method for Treatment of Severe Oral Corticosteroid-Dependent Asthma and Other Respiratory Diseases 有权用于流量和体积调节吸入的药物和装置组合系统和治疗严重口服皮质类固醇依赖性哮喘和其他呼吸道疾病的方法公开(公告)号：US20130037024A1
公开(公告)日：2013-02-14
申请号：US13605451
申请日：2012-09-06
IPC分类号： A61M15/00
CPC分类号： A61K9/0078 , A61M11/005 , A61M11/06 , A61M2016/0024 , A61M2016/0027 , A61M2205/502 , Y10S514/862 , Y10S514/958
摘要： A drug and device combination system used in a method for treatment of patients suffering from severe and oral corticosteroid-dependent asthma and other respiratory diseases requiring a treatment with orally administered steroids. The method for administration of the inhalable corticosteroid by a flow rate and volume regulated inhalation. The combination system of the inhalable corticosteroid and the device for regulating flow rate and volume of the inhalable corticosteroid and thus achieving delivery of said inhalable corticosteroid into the small airways of the lungs. The individually programmable device that assures safe and reproducible corticosteroid delivery compliant with treatment protocol.
摘要翻译： 用于治疗患有严重和口服皮质类固醇依赖性哮喘和需要口服给药的类固醇治疗的其它呼吸道疾病的患者的方法中的药物和装置组合系统。 通过流量和体积调节吸入给药可吸入皮质类固醇的方法。 可吸入皮质类固醇的组合系统和用于调节可吸入皮质类固醇的流速和体积的装置，从而实现将所述可吸入的皮质类固醇递送到肺的小气道中。 可单独编程的设备，确保符合治疗方案的安全可重复的皮质类固醇输送。
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4.发明申请METHODS, SYSTEMS AND COMPUTER-READABLE PRODUCTS FOR OPTIMIZING AEROSOL PARTICLE ADMINISTRATION TO THE LUNGS 审中-公开方法，系统和计算机可读产品，用于优化喷雾剂颗粒管理给LUNGS公开(公告)号：US20090178672A1
公开(公告)日：2009-07-16
申请号：US12327940
申请日：2008-12-04
CPC分类号： A61M15/00 , A61M11/005 , A61M16/107 , A61M2016/0027 , A61M2205/52 , A61M2209/084
摘要： The present invention is directed to methods, systems and computer-readable products for optimizing aerosol particle administration to the lungs. More specifically, the present invention relates to methods of tailoring inhaling maneuvers for aerosol particle administration using the subject's lung function data and to systems and computer-readable products carrying out such methods.
摘要翻译： 本发明涉及用于优化气雾剂对肺的给药的方法，系统和计算机可读产品。 更具体地，本发明涉及使用受试者的肺功能数据和实施这些方法的系统和计算机可读产品来调整用于气溶胶粒子给药的吸入动作的方法。
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5.发明授权Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma 有权使用糖皮质激素组合物治疗严重和不受控制的哮喘公开(公告)号：US08668901B2
公开(公告)日：2014-03-11
申请号：US13147761
申请日：2010-02-03
CPC分类号： A61K31/573 , A61K9/0078 , A61K31/56 , A61K31/58
摘要： Methods, devices and compositions for treatment of severe and uncontrolled asthma are provided by which high amounts of an inhaled corticosteroid are directed to the small airways of the lower lungs. The invention provides for a substantial decrease in the dose of concurrently administered oral corticosteroids. A particular advantage of the invention is the significant reduction in corticosteroid-related adverse effects.
摘要翻译： 提供了用于治疗严重和不受控制的哮喘的方法，装置和组合物，其中大量的吸入性皮质类固醇被引导到下肺的小气道。 本发明提供同时施用的口服皮质类固醇的剂量的显着降低。 本发明的特别优点在于皮质类固醇相关的不利影响的显着降低。
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公开(公告)号：US20130034534A1
公开(公告)日：2013-02-07
申请号：US13497504
申请日：2010-09-29
CPC分类号： A61M11/005 , A61K9/0073 , A61K9/12 , A61K38/465 , A61M11/001 , A61M11/06 , A61M15/0083 , A61M15/0091 , A61M2016/0024 , A61M2205/52
摘要： A method for treatment of patients with cystic fibrosis by providing an inhalable aerosol comprising a mucolytic compound (dornase alpha) administered into a patient's lungs according to a specific treatment protocol setting comprising a mucolytic drug containing aerosol having particles with a predetermined mass medial aerodynamic diameter (MMAD) delivered predominantly to a peripheral lungs using a nebulizing system able to administer said aerosol with overpressure and under controlled breathing conditions.
摘要翻译： 一种通过提供一种可吸入的气溶胶来治疗囊性纤维化患者的方法，所述吸入性气溶胶包含根据特定治疗方案设置施用于患者肺部的粘液溶解化合物（dornaseα），其包含含有具有预定质量中间空气动力学直径的颗粒的溶解性药物 MMAD）使用能够以超压和受控呼吸条件施用所述气溶胶的雾化系统主要递送至外周肺。
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公开(公告)号：US20100196483A1
公开(公告)日：2010-08-05
申请号：US12365754
申请日：2009-02-04
CPC分类号： A61K9/0078 , A61K31/573
摘要： A method for treatment of severe and uncontrollable asthma by providing means for delivery of high doses of a suitable inhalable corticosteroid directly to the small airways of the lower lungs with substantial decrease in need for simultaneous administration of oral corticosteroids and with a significant reduction in undesirable secondary side effects in an oropharyngeal area. The method utilizes devices allowing individualization of treatment parameters in asthmatic patients having compromised breathing pattern due to severe and uncontrollable asthma.
摘要翻译： 一种治疗严重和不可控哮喘的方法，提供了将大剂量合适的可吸入皮质类固醇直接递送到下肺的小气道的手段，同时大量减少了口服皮质类固醇的同时施用，并显着减少了不良次级 在口咽区域有副作用。 该方法使用允许由于严重和不可控制的哮喘而患有呼吸模式受损的哮喘患者中的治疗参数个体化的装置。
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