公开(公告)号：US5846817A

公开(公告)日：1998-12-08

申请号：US520578

申请日：1995-08-29

申请人： Pierre-Alain Mausli

发明人： Pierre-Alain Mausli

IPC分类号： C12M1/40 ,  B01F3/04 ,  C12M1/06 ,  C12M3/00 ,  C12M3/02

CPC分类号： C12M23/34 ,  B01F3/04531 ,  C12M27/10 ,  C12M41/40

摘要： A bioreactor, in particular for a microgravity, comprising at least one cell culture chamber, an oxygen supply and an agitator for a cell culture. In particular, the chamber includes two housing elements (1, 2) having a first (1', 9) and a second (2', 9') wall region, as well as a first (3) and a second (4) separating element extending from respectively the first (1', 9) and the second (2', 9') wall regions in the direction respectively of the second (2', 9') and the first (1', 9) wall regions. The separating region or regions of the separating elements has (have) a height (h) less than the distance (D) between the first (1', 9) and the second (2', 9') wall regions. The agitator includes a first and second devices (7) for moving the two housing elements (1, 2) with respect to each other.

摘要翻译： 生物反应器，特别是用于微重力的生物反应器，其包含至少一个细胞培养室，氧气供应和用于细胞培养的搅拌器。 特别地，腔室包括具有第一（1'，9）和第二（2'，9'）壁区域的两个壳体元件（1,2），以及第一（3）和第二（4） 分别从第一（1'，9）和第二（2'，9'）壁区域分别沿第二（2'，9'）和第一（1'，9）壁区域 。 分离元件的分离区域具有小于第一（1'，9）和第二（2'，9'）壁区域之间的距离（D）的高度（h）。 搅拌器包括用于相对于彼此移动两个壳体元件（1,2）的第一和第二装置（7）。

公开(公告)号：US20060264913A1

公开(公告)日：2006-11-23

申请号：US11476372

申请日：2006-06-27

申请人： Andrew Poutiatine ,  Edward Gillis ,  Pierre-Alain Mausli ,  Volker Gass

发明人： Andrew Poutiatine ,  Edward Gillis ,  Pierre-Alain Mausli ,  Volker Gass

IPC分类号： A61K9/22

CPC分类号： A61M5/16881 ,  A61M2205/04

摘要： An implantable flow regulator (22) for regulating flow of a drug along a drug delivery pathway (14) from a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is “closed”), and a second mode position where the diversion member (24) is position to allow flow through the delivery pathway (14) (i.e., delivery pathway is “open”). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or “closed” position, which is also a failsafe position, toward its second mode or “open” position. In the “open” position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.

摘要翻译： 用于调节药物沿着药物输送路径（14）从药物源到受治疗者内的治疗部位的流动的可植入流量调节器（22）包括可移动分支构件（24）和致动器。 可移动分支构件（24）可操作地联接到输送路径（14）。 所述致动器可致动以在所述转向构件（24）限制流经所述输送通道（14）（即，输送路径为“闭合”）的至少第一模式位置和第二模式之间移动所述转向构件（24） 分流构件（24）位于允许流过输送路径（14）（即，输送路径“打开”）的位置。 用于致动致动器的供电使得转向构件（24）从其正常偏置的第一模式或“关闭”位置（其也是故障安全位置）朝向其第二模式或“打开”位置移动。 在“开放”的位置，药物通常由监管机构内的药物储备供应给目标地点。

公开(公告)号：US20060009739A1

公开(公告)日：2006-01-12

申请号：US10525882

申请日：2002-09-06

申请人： Andrew Poutiatine ,  Edward Gillis ,  Pierre-Alain Mausli ,  Volker Gass

发明人： Andrew Poutiatine ,  Edward Gillis ,  Pierre-Alain Mausli ,  Volker Gass

IPC分类号： A61M5/00

CPC分类号： A61M5/16881 ,  A61M2205/04

摘要： An implantable flow regulator (22) for regulating flow of a drug along drug delivery pathway (14) form a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is “closed”), and a second mode position where the diversion member (24) is positioned to allow flow through the delivery pathway (14) (i.e., delivery pathway is “open”). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or “closed” position, which is also a failsafe position, toward its second mode or “open” position. In the “open” position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.

摘要翻译： 用于调节药物沿着药物递送通道（14）的流动的可植入流量调节器（22）形成药物源到受试者内的治疗部位，包括可移动分支构件（24）和致动器。 可移动分支构件（24）可操作地联接到输送路径（14）。 所述致动器可致动以在所述转向构件（24）限制流经所述输送通道（14）（即，输送路径为“闭合”）的至少第一模式位置和第二模式之间移动所述转向构件（24） 分流构件（24）被定位成允许流过输送路径（14）（即，输送路径“打开”）的位置。 用于致动致动器的供电使得转向构件（24）从其正常偏置的第一模式或“关闭”位置（其也是故障安全位置）朝向其第二模式或“打开”位置移动。 在“开放”的位置，药物通常由监管机构内的药物储备供应给目标地点。