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公开(公告)号：US20190382462A1
公开(公告)日：2019-12-19
申请号：US16477613
申请日：2018-01-12
申请人： Pietro P. SANNA , Linda S. LLOYD
发明人： Pietro P. SANNA , Linda S. LLOYD
IPC分类号： C07K14/575 , C07K14/72
摘要： Disclosed are engineered corticotropin-releasing factor (CRF) antagonist agents, including engineered corticotropin-releasing factor (CRF) binding agents. The CRF antagonist agents and binding agents can be used to neutralize excess CRF in vivo and comprise a polypeptide having CRF-specific binding activity under physiological conditions coupled to one or more half-life-extending moieties. Pharmaceutical compositions are disclosed containing the CRF binding agents, which can be used in methods of treatment for diseases, disorders, or conditions involving hypothalamic pituitary adrenal (HPA) axis hyperactivity. Also disclosed are engineered nucleic acids (e.g., expression constructs or vectors) encoding the CRF binding agents and recombinant host cells comprising the engineered nucleic acids.
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公开(公告)号：US08847003B2
公开(公告)日：2014-09-30
申请号：US13348596
申请日：2012-01-11
申请人： Pietro P. Sanna
发明人： Pietro P. Sanna
IPC分类号： A61K49/00
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.
摘要翻译： 本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。 本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。
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公开(公告)号：US20140173764A9
公开(公告)日：2014-06-19
申请号：US13348596
申请日：2012-01-11
申请人： Pietro P. SANNA
发明人： Pietro P. SANNA
IPC分类号： A61K49/00
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.
摘要翻译： 本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。 本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。
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公开(公告)号：US20100199361A1
公开(公告)日：2010-08-05
申请号：US12085381
申请日：2006-11-21
申请人： Pietro P. Sanna
发明人： Pietro P. Sanna
IPC分类号： A01K67/00 , A61K38/08 , A61K38/07 , A61K31/7105 , A61K31/5355 , C07K7/06 , A61P25/36 , C12Q1/37
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.
摘要翻译： 本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。 本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。
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公开(公告)号：US07060799B2
公开(公告)日：2006-06-13
申请号：US10079802
申请日：2002-02-19
CPC分类号： C07K16/00 , C07K16/087 , C07K2317/21 , C07K2317/55
摘要： The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.
摘要翻译： 本发明提供了用于鉴定和克隆结合独特表位的抗体的克隆分离的新方法。 该方法基于使用抗体作为固相捕获试剂来结合已知的捕获抗体表位，从而排除了捕获抗体表位被呈递给要筛选的抗体群体。 该方法特别适用于筛选克隆抗体的文库，例如噬菌体展示组合抗体。 采用特异于单纯疱疹病毒（HSV）的抗体作为测定的模型。
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公开(公告)号：US20120174240A1
公开(公告)日：2012-07-05
申请号：US13348596
申请日：2012-01-11
申请人： Pietro P. SANNA
发明人： Pietro P. SANNA
IPC分类号： A61K49/00
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.
摘要翻译： 本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。 本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。
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公开(公告)号：US06376170B1
公开(公告)日：2002-04-23
申请号：US08972564
申请日：1997-11-18
IPC分类号： C12Q170
CPC分类号： C07K16/00 , C07K16/087 , C07K2317/21 , C07K2317/55
摘要： The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.
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