公开(公告)号：US20190142980A1

公开(公告)日：2019-05-16

申请号：US16096505

申请日：2017-05-03

Applicant: Consigiio Nazionale deiie Ricerche ,  Plasma Diagnostics and Technologies S.r.l. ,  Universita degli Studi di Firenze

Inventor： Angela ZOPPI ,  Mario DEL ROSSO ,  Anna LAURENZANA ,  Gabriella FIBBI ,  Francesca MARCHERI ,  Anastasia CHILLA' ,  Giancario MARCHERI

IPC: A61K51/12 ,  A61K49/00 ,  A61K41/00 ,  A61K47/69

Abstract: The present invention refers to cells from a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, to a composition having a plurality of these cells and to their use in the diagnosis and treatment of solid tumours thanks to the selective localization of the composition in the tumour mass, which can be thus identified easily for diagnostic purposes by marking the cells with appropriate marking agents, or treated by stimulation with pulsed laser beam up to the complete cauterization of the tumour mass for a targeted and highly effective therapeutic action.

公开(公告)号：US12064492B2

公开(公告)日：2024-08-20

申请号：US16096505

申请日：2017-05-03

Applicant: Consiglio Nazionale delle Ricerche ,  Plasma Diagnostics and Technologies S.r.l. ,  Universita degli Studi di Firenze

Inventor： Angela Zoppi ,  Mario Del Rosso ,  Anna Laurenzana ,  Gabriella Fibbi ,  Francesca Margheri ,  Anastasia Chilla' ,  Giancarlo Margheri

IPC: A61K9/00 ,  A61K33/242 ,  A61K35/28 ,  A61K41/00 ,  A61K47/69 ,  A61K49/00 ,  A61K51/12 ,  A61P35/00

CPC classification number: A61K51/1203 ,  A61K33/242 ,  A61K35/28 ,  A61K41/0052 ,  A61K47/6901 ,  A61K49/0065 ,  A61P35/00

Abstract: The present invention refers to cells from a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, to a composition having a plurality of these cells and to their use in the diagnosis and treatment of solid tumours thanks to the selective localization of the composition in the tumour mass, which can be thus identified easily for diagnostic purposes by marking the cells with appropriate marking agents, or treated by stimulation with pulsed laser beam up to the complete cauterization of the tumour mass for a targeted and highly effective therapeutic action.