公开(公告)号：US20180369817A1

公开(公告)日：2018-12-27

申请号：US16015617

申请日：2018-06-22

申请人： Pouya REZAI ,  Pouriya BAYAT

发明人： Pouya REZAI ,  Pouriya BAYAT

IPC分类号： B01L3/00 ,  B03C1/30 ,  B03C1/28 ,  G01N1/38

摘要： Systems and methods are provided that enable the magnetophoretic separation of magnetic particles using Dean flow in curved fluidic channels. In some example embodiments, a magnetic microparticle solution and a buffer solution are injected into a proximal region of a curved fluidic channel, and channel and fluidic parameters are selected to achieve solution exchange via Dean flow, such that the lateral positions of injected laminar fluid streams are inverted in a distal region of the channel. An applied magnetic field gradient is employed to retain the magnetic microparticles proximal to a channel side wall during the solution exchange process, such that magnetic microparticles are separated into the buffer solution. Various example device configurations are disclosed, including example configurations including one or more additional fluidic components for the further processing of separated magnetic particles.

公开(公告)号：US10859490B2

公开(公告)日：2020-12-08

申请号：US15839325

申请日：2017-12-12

申请人： Pouya Rezai ,  Nima Tabatabaei ,  Ashkan Ojaghi

发明人： Pouya Rezai ,  Nima Tabatabaei ,  Ashkan Ojaghi

IPC分类号： G01N21/71 ,  G01N21/17 ,  G01N33/50 ,  G01N33/53 ,  G01N33/558 ,  G01N33/68 ,  G01N33/543 ,  G03C1/498

摘要： A system and method for photo-thermal imaging of a lateral flow immunoassay (LFA) device are provided. The system includes an intensity modulated heat source directed at a surface of the LFA device to selectively excite chromophore particles of interest and a thermal capture device configured to capture thermal waves emitted from the surface of the LFA device as a radiometric signal. A computing device, in communication with the thermal capture device, receives the radiometric signal and executes lock-in demodulation to detect surface or subsurface inhomogeneities of the LFA device.

公开(公告)号：US20120061240A1

公开(公告)日：2012-03-15

申请号：US13234039

申请日：2011-09-15

申请人： Ravi (Ponnambalam) Selvaganapathy ,  Bhagwati Gupta ,  Pouya Rezai

发明人： Ravi (Ponnambalam) Selvaganapathy ,  Bhagwati Gupta ,  Pouya Rezai

IPC分类号： G01N27/447 ,  A01K29/00

CPC分类号： A01K67/033 ,  A01K29/005

摘要： A method of controlling nematode response in a microfluidic environment is provided comprising exposing the nematode to an electric field that induces a nematode response. In one embodiment, a method of sorting a group of nematodes based on a selected parameter is provided comprising the step of exposing the nematodes to an electric field that induces a differential response among the nematodes based on the selected parameter, wherein the differential response functions to separate the nematodes based on the selected parameter. Devices useful to achieve these methods are also provided.

摘要翻译： 提供了一种在微流体环境中控制线虫反应的方法，包括将线虫暴露于诱导线虫反应的电场。 在一个实施例中，提供了一种基于所选择的参数对一组线虫进行排序的方法，其包括将线虫暴露于根据所选择的参数引起线虫之间的差异响应的电场的步骤，其中差分响应函数为 根据所选参数分离线虫。 还提供了实现这些方法有用的装置。

公开(公告)号：US20190154564A1

公开(公告)日：2019-05-23

申请号：US15839325

申请日：2017-12-12

申请人： Pouya REZAI ,  Nima TABATABAEI ,  Ashkan OJAGHI

发明人： Pouya REZAI ,  Nima TABATABAEI ,  Ashkan OJAGHI

IPC分类号： G01N21/17 ,  G01N33/558 ,  G03C1/498 ,  G01N33/68 ,  G01N33/543

摘要： A system and method for photo-thermal imaging of a lateral flow immunoassay (LFA) device are provided. The system includes an intensity modulated heat source directed at a surface of the LFA device to selectively excite chromophore particles of interest and a thermal capture device configured to capture thermal waves emitted from the surface of the LFA device as a radiometric signal. A computing device, in communication with the thermal capture device, receives the radiometric signal and executes lock-in demodulation to detect surface or subsurface inhomogeneities of the LFA device.

公开(公告)号：US08702939B2

公开(公告)日：2014-04-22

申请号：US13234039

申请日：2011-09-15

申请人： Ravi (Ponnambalam) Selvaganapathy ,  Bhagwati Gupta ,  Pouya Rezai

发明人： Ravi (Ponnambalam) Selvaganapathy ,  Bhagwati Gupta ,  Pouya Rezai

IPC分类号： G01N27/447 ,  B03C9/00

CPC分类号： A01K67/033 ,  A01K29/005

摘要： A method of controlling nematode response in a microfluidic environment is provided comprising exposing the nematode to an electric field that induces a nematode response. In one embodiment, a method of sorting a group of nematodes based on a selected parameter is provided comprising the step of exposing the nematodes to an electric field that induces a differential response among the nematodes based on the selected parameter, wherein the differential response functions to separate the nematodes based on the selected parameter. Devices useful to achieve these methods are also provided.

摘要翻译： 提供了一种在微流体环境中控制线虫反应的方法，包括将线虫暴露于诱导线虫反应的电场。 在一个实施例中，提供了一种基于所选择的参数对一组线虫进行排序的方法，其包括将线虫暴露于根据所选择的参数引起线虫之间的差异响应的电场的步骤，其中差分响应函数为 根据所选参数分离线虫。 还提供了实现这些方法有用的装置。

公开(公告)号：US20180369807A1

公开(公告)日：2018-12-27

申请号：US16015591

申请日：2018-06-22

申请人： Pouya REZAI ,  Pouriya BAYAT

发明人： Pouya REZAI ,  Pouriya BAYAT

IPC分类号： B01L3/00 ,  B01D21/26

摘要： A microfluidic centrifuge device for solution exchange and separation. The device includes a curved fluidic channel, a first inlet and a second inlet in fluid communication with a proximal end of the curved fluid channel, and a first outlet and a second outlet in fluid communication with a distal end of the curved fluidic channel. The curved fluidic channel has dimensions sufficient to direct a first subset of the microparticles to the first outlet by Dean drag and a second subset of the microparticles to the second outlet by inertial force.