公开(公告)号：US20090076094A1

公开(公告)日：2009-03-19

申请号：US12226403

申请日：2007-04-10

申请人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

发明人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

IPC分类号： A61K31/4439 ,  C07D417/14 ,  A61P31/04 ,  C12P17/16

CPC分类号： A61K38/12 ,  C07K5/0821

摘要： This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

摘要翻译： 本发明涉及分子量为1514和分子式C69H66N18O13S5的新型纯化的化合物PM181104; 其通过发酵属于Kocuria物种（ZMA B-1 / MTCC 5269）的微生物获得。 本发明包括化合物PM181104的所有立体异构体形式和所有互变异构形式以及药学上可接受的盐和衍生物如酯和醚。 本发明还涉及生产新型抗菌化合物的方法，用于生产属于Kocuria种的微生物（ZMA B-1 / MTCC 5269），以及含有新化合物的药物组合物， 作为活性成分及其在用于治疗和预防由细菌感染引起的疾病的药物中的用途。

公开(公告)号：US08003602B2

公开(公告)日：2011-08-23

申请号：US12226403

申请日：2007-04-10

申请人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

发明人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

IPC分类号： A61K38/12

CPC分类号： A61K38/12 ,  C07K5/0821

摘要： This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

摘要翻译： 本发明涉及分子量为1514和分子式C69H66N18O13S5的新型纯化的化合物PM181104; 其通过发酵属于Kocuria物种（ZMA B-1 / MTCC 5269）的微生物获得。 本发明包括化合物PM181104的所有立体异构体形式和所有互变异构形式以及药学上可接受的盐和衍生物如酯和醚。 本发明还涉及生产新型抗菌化合物的方法，用于生产属于Kocuria种的微生物（ZMA B-1 / MTCC 5269），以及含有新化合物的药物组合物， 作为活性成分及其在用于治疗和预防由细菌感染引起的疾病的药物中的用途。