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    ANTIBIOTIC COMPOUNDS
    5.
    发明申请
    ANTIBIOTIC COMPOUNDS 审中-公开
    抗生素化合物

    公开(公告)号：US20120156295A1

    公开(公告)日：2012-06-21

    申请号：US13393294

    申请日：2010-08-31

    申请人： Prabhu Dutt Mishra ,  Girish Badrinath Mahajan

    发明人： Prabhu Dutt Mishra ,  Girish Badrinath Mahajan

    IPC分类号： A61K38/12 ,  C12P21/04 ,  A61K9/107 ,  A61P31/04 ,  C07K7/54 ,  A61K9/28

    CPC分类号： C07K5/10 ,  A61K38/00 ,  C07D513/18 ,  C07K5/101

    摘要： Purified compounds of formula I are described. Compounds include all stereoisomeric forms and all tautomeric forms of the compounds of formula I and pharmaceutically acceptable salts and derivatives. Processes for the production of the antibacterial compounds by fermentation of the microorganism belonging to Streptomyces species (PM0626271/MTCC 5447) and to pharmaceutical compositions containing one or more of the novel compounds as active ingredient and their use in medicines for treatment and prevention of diseases caused by bacterial infections are described.

    摘要翻译： 描述了式I的纯化化合物。 化合物包括式I化合物的所有立体异构形式和所有互变异构形式及其药学上可接受的盐和衍生物。 用于通过发酵属于链霉菌属（PM0626271 / MTCC 5447）的微生物生产抗菌化合物的方法和含有一种或多种新化合物作为活性成分的药物组合物及其在治疗和预防疾病中的用途 通过细菌感染进行描述。

    Microparticle formulation for pulmonary drug delivery of anti infective molecule for treatment of infectious diseases
    6.
    发明授权
    Microparticle formulation for pulmonary drug delivery of anti infective molecule for treatment of infectious diseases 有权
    用于治疗感染性疾病的抗感染性分子的肺部药物递送的微粒制剂

    公开(公告)号：US08697653B2

    公开(公告)日：2014-04-15

    申请号：US13813470

    申请日：2011-08-04

    申请人： Geetanjali Chandrashekhar Chimote ,  Girish Badrinath Mahajan ,  Aravindan Vasudevan ,  Sivaramakrishnan Hariharan

    发明人： Geetanjali Chandrashekhar Chimote ,  Girish Badrinath Mahajan ,  Aravindan Vasudevan ,  Sivaramakrishnan Hariharan

    IPC分类号： A61K38/12

    CPC分类号： A61K38/12 ,  A61K9/0078 ,  A61K9/127 ,  A61K31/4745

    摘要： The present invention relates to a biodegradable, inhalable microparticle formulation comprising a compound of formula I obtained by fermentation of a microorganism of the Streptomyces species (PM0626271/MTCC5447), as described in PCT application publication WO2011027290, and a biodegradable lipid for drug delivery wherein the ratio of drug (compound of formula I) to lipid is 1:15 to 1:25. The present invention also relates to the process for preparation of the formulation and to the method of treatment of pulmonary tuberculosis, multi drug resistant tuberculosis (MDRTB), methicillin resistant Staphylococcus aureus (MRSA) pneumonias and methicillin sensitive Staphylococcus aureus (MSSA) pneumonias by administering therapeutically effective amount of the formulation to a mammal in need thereof. The present invention further relates to a method of delivering the microparticle formulation to a mammal in need thereof, wherein the formulation is administered by inhalation or intratracheal instillation for pulmonary delivery.

    摘要翻译： 本发明涉及一种可生物降解的可吸入微粒制剂，其包含如PCT申请公开WO 2011027290中所述通过发酵Streptomyces物种微生物（PM0626271 / MTCC5447）获得的式I化合物和用于药物递送的可生物降解的脂质，其中 药物（式I化合物）与脂质的比例为1:15至1:25。 本发明还涉及制剂的制备方法和治疗肺结核，多药耐药结核病（MDRTB），耐甲氧西林金黄色葡萄球菌（MRSA）肺炎和甲氧西林敏感性金黄色葡萄球菌（MSSA）肺炎的方法，通过施用 给予有需要的哺乳动物的治疗有效量的制剂。 本发明还涉及将微粒制剂递送至有需要的哺乳动物的方法，其中所述制剂通过吸入或气管内滴注给予肺部输送。

    MICROPARTICLE FORMULATION FOR PULMONARY DRUG DELIVERY OF ANTI INFECTIVE MOLECULE FOR TREATMENT OF INFECTIOUS DISEASES
    7.
    发明申请
    MICROPARTICLE FORMULATION FOR PULMONARY DRUG DELIVERY OF ANTI INFECTIVE MOLECULE FOR TREATMENT OF INFECTIOUS DISEASES 有权
    用于治疗感染性疾病的抗感染性分子的脉冲药物递送的微生物制剂

    公开(公告)号：US20130125879A1

    公开(公告)日：2013-05-23

    申请号：US13813470

    申请日：2011-08-04

    申请人： Geetanjali Chandrashekhar Chimote ,  Girish Badrinath Mahajan ,  Aravindan Vasudevan ,  Sivaramakrishnan Hariharan

    发明人： Geetanjali Chandrashekhar Chimote ,  Girish Badrinath Mahajan ,  Aravindan Vasudevan ,  Sivaramakrishnan Hariharan

    IPC分类号： A61K38/12

    CPC分类号： A61K38/12 ,  A61K9/0078 ,  A61K9/127 ,  A61K31/4745

    摘要： The present invention relates to a biodegradable, inhalable microparticle formulation comprising a compound of formula I obtained by fermentation of a microorganism of the Streptomyces species (PM0626271/MTCC5447), as described in PCT application publication WO2011027290, and a biodegradable lipid for drug delivery wherein the ratio of drug (compound of formula I) to lipid is 1:15 to 1:25. The present invention also relates to the process for preparation of the formulation and to the method of treatment of pulmonary tuberculosis, multi drug resistant tuberculosis (MDRTB), methicillin resistant Staphylococcus aureus (MRSA) pneumonias and methicillin sensitive Staphylococcus aureus (MSSA) pneumonias by administering therapeutically effective amount of the formulation to a mammal in need thereof. The present invention further relates to a method of delivering the microparticle formulation to a mammal in need thereof, wherein the formulation is administered by inhalation or intratracheal instillation for pulmonary delivery.

    摘要翻译： 本发明涉及一种可生物降解的可吸入微粒制剂，其包含如PCT申请公开WO 2011027290中所述通过发酵Streptomyces物种微生物（PM0626271 / MTCC5447）获得的式I化合物和用于药物递送的可生物降解的脂质，其中 药物（式I化合物）与脂质的比例为1:15至1:25。 本发明还涉及制剂的制备方法和治疗肺结核，多药耐药结核病（MDRTB），耐甲氧西林金黄色葡萄球菌（MRSA）肺炎和甲氧西林敏感性金黄色葡萄球菌（MSSA）肺炎的方法，通过施用 给予有需要的哺乳动物的治疗有效量的制剂。 本发明还涉及将微粒制剂递送至有需要的哺乳动物的方法，其中所述制剂通过吸入或气管内滴注给予肺部输送。