公开(公告)号：US08003602B2

公开(公告)日：2011-08-23

申请号：US12226403

申请日：2007-04-10

申请人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

发明人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

IPC分类号： A61K38/12

CPC分类号： A61K38/12 ,  C07K5/0821

摘要： This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

摘要翻译： 本发明涉及分子量为1514和分子式C69H66N18O13S5的新型纯化的化合物PM181104; 其通过发酵属于Kocuria物种（ZMA B-1 / MTCC 5269）的微生物获得。 本发明包括化合物PM181104的所有立体异构体形式和所有互变异构形式以及药学上可接受的盐和衍生物如酯和醚。 本发明还涉及生产新型抗菌化合物的方法，用于生产属于Kocuria种的微生物（ZMA B-1 / MTCC 5269），以及含有新化合物的药物组合物， 作为活性成分及其在用于治疗和预防由细菌感染引起的疾病的药物中的用途。

公开(公告)号：US20090076094A1

公开(公告)日：2009-03-19

申请号：US12226403

申请日：2007-04-10

申请人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

发明人： Girish Badrinath Mahajan ,  Saji David George ,  Prafull Vasant Ranadive ,  Prabhu Dutt Satyanarayan Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyil ,  Rajan Mukund Panshikar ,  Satish Namdeo Sawant ,  Sridevi Krishna ,  Meenakshi Sivakumar ,  Koteppa Pari ,  Becky Mary Thomas ,  Zarine Eruch Patel ,  Ram Vishwakarma ,  Chandrakant Govind Naik ,  Lisette D'Souza ,  Prabha Devi

IPC分类号： A61K31/4439 ,  C07D417/14 ,  A61P31/04 ,  C12P17/16

CPC分类号： A61K38/12 ,  C07K5/0821

摘要： This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

摘要翻译： 本发明涉及分子量为1514和分子式C69H66N18O13S5的新型纯化的化合物PM181104; 其通过发酵属于Kocuria物种（ZMA B-1 / MTCC 5269）的微生物获得。 本发明包括化合物PM181104的所有立体异构体形式和所有互变异构形式以及药学上可接受的盐和衍生物如酯和醚。 本发明还涉及生产新型抗菌化合物的方法，用于生产属于Kocuria种的微生物（ZMA B-1 / MTCC 5269），以及含有新化合物的药物组合物， 作为活性成分及其在用于治疗和预防由细菌感染引起的疾病的药物中的用途。

公开(公告)号：US07341855B2

公开(公告)日：2008-03-11

申请号：US11364029

申请日：2006-03-01

申请人： Prabha Devi ,  Chandrakant Govind Naik ,  Solimabi Wahidulla ,  Lisette D'Souza ,  Ely Rodrigues ,  Asha Peketi

发明人： Prabha Devi ,  Chandrakant Govind Naik ,  Solimabi Wahidulla ,  Lisette D'Souza ,  Ely Rodrigues ,  Asha Peketi

IPC分类号： C12P7/02 ,  C12P7/04 ,  C12P7/14 ,  C12P7/18

CPC分类号： C12R1/645 ,  C12P7/18

摘要： The present invention relates to a plant mangrove-associated fungus Curvularia lunata, and a simple and efficient method of obtaining high yield of pure mannitol from a plant mangrove-associated fungus Curvularia lunata, said method comprising steps of cutting the leaves into small pieces and placing it on potato dextrose agar (PDA) plates for 48 hours, maintaining the culture at temperature ranging between 26-47° C. and salinity ranging between 4-32 ppt with occasional stress conditions for about 17-19 days to obtain mycelial mat, sonicating the mat to lyse the cells, extracting crude from the sonicated mat using methanol repeatedly, concentrating the crude, treating the concentrated crude extract with solvents of increasing polarity, obtaining aqueous fraction as white powder residue after the treatment containing crude mannitol, purifying the crude mannitol by chromatography to obtain pure mannitol with about 75% of the total crude extract.

摘要翻译： 本发明涉及植物红树林相关真菌弯孢菌，以及从植物红树植物相关真菌弯孢杆菌获得高纯度甘露醇的简单有效的方法，所述方法包括以下步骤：将叶片切成小块并放置 在马铃薯葡萄糖琼脂（PDA）板上培养48小时，保持培养温度在26-47℃之间，盐度范围在4-32ppt之间，偶尔的应激条件约17-19天以获得菌丝体垫，超声处理 将细胞裂解细胞，用甲醇反复提取粗品，浓缩粗品，浓缩粗提物用极性增加的溶剂处理，得到处理后含有粗甘露醇的白色粉末残渣的水分，纯化粗甘露醇 通过色谱法获得纯甘露醇与总粗提物的约75％。

公开(公告)号：US06667062B2

公开(公告)日：2003-12-23

申请号：US10108760

申请日：2002-03-27

申请人： Cynthia Olimpia Lydia Gonsalves ,  Chittur Thelakkat Achuthankutty ,  Perunninakulath Parameswaran Subrayan ,  Chandrakant Govind Naik

发明人： Cynthia Olimpia Lydia Gonsalves ,  Chittur Thelakkat Achuthankutty ,  Perunninakulath Parameswaran Subrayan ,  Chandrakant Govind Naik

IPC分类号： A61K3512

CPC分类号： A61K38/56

摘要： The present invention relates to a composition useful as an anti-fouling agent by inhibiting microbial growth, said comprising extract and/or its fractions from Zoanthus sp. and optionally de-odorizing agents and a method of producing said extract and its fractions having about 100% anti-bacterial activity fouling microbes.

摘要翻译： 本发明涉及通过抑制微生物生长而用作防污剂的组合物，所述组合物包含来自Zoanthus sp。的提取物和/或其馏分。 和任选的除臭剂以及产生所述提取物及其部分的方法，其具有约100％的抗细菌活性污染微生物。

公开(公告)号：US06617319B2

公开(公告)日：2003-09-09

申请号：US10050616

申请日：2002-01-16

申请人： Cynthia Olimpia Lydia Gonsalves ,  Perunninakulath Parameswaran Subrayan ,  Chandrakant Govind Naik ,  Chittur Thelakkat Achuthankutty

发明人： Cynthia Olimpia Lydia Gonsalves ,  Perunninakulath Parameswaran Subrayan ,  Chandrakant Govind Naik ,  Chittur Thelakkat Achuthankutty

IPC分类号： A61K3156

CPC分类号： C07J5/00 ,  A61K31/56 ,  C07J7/00

摘要： The invention provides a process for the isolation of 2-deoxy ecdysterone from Zoanthus sp process comprising the steps (a) preparing crude methanol extract of Zoanthus sp., (b) subjecting the crude methanol extract to fractionation using petroleum ether, ethyl acetate, chloroform, n-butanol and mixtures thereof to yield a fraction, (c) subjecting the active fraction to flash chromatography over silica gel to obtain partially purified active compound, and (d) subjecting the active subfraction obtained from step (c) above to gel permeation chromatography to obtain the active pure compound.

摘要翻译： 本发明提供了一种从Zoanthus sp方法分离2-脱氧蜕皮甾酮的方法，包括步骤（a）制备Zoanthus sp。的粗甲醇提取物，（b）使用石油醚，乙酸乙酯，氯仿 ，正丁醇及其混合物以产生级分，（c）使活性级分经硅胶快速色谱法获得部分纯化的活性化合物，和（d）使由上述步骤（c）获得的活性亚馏分经凝胶渗透 色谱法得到活性纯化合物。