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1.发明授权公开(公告)号：US11948283B2
公开(公告)日：2024-04-02
申请号：US17604613
申请日：2020-04-23
CPC分类号： G06T5/009 , G06T7/0012 , G06T2207/10104 , G06T2207/10108 , G06T2207/20092 , G06T2207/20208 , G06T2207/30008
摘要： Presented herein are systems and methods that provide for improved computer aided display and analysis of nuclear medicine images. In particular, the systems and methods described herein offer improved interactive adjustment of intensity windowing for display of nuclear medicine images. The interactive intensity window selection tools described herein utilize a nonlinear scaling function that maps user adjustments to positions of displayed indicator widgets on a scale to intensity window thresholds. The form of the scaling function increasingly magnifies user adjustments at the upper range of the scale, but remains linear at the lower end. The intensity windowing tools presented herein allow the user to adjust intensity thresholds over a full range of intensities encountered in an image, up to the maximum value, while still preserving fidelity in an important range that includes lower intensities.
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公开(公告)号：US20230205931A1
公开(公告)日：2023-06-29
申请号：US18072000
申请日：2022-11-30
IPC分类号： G06F21/62 , H04L9/40 , G06F3/0482 , G06F16/58 , G16H30/20
CPC分类号： G06F21/6254 , H04L63/20 , G06F3/0482 , G06F16/5866 , G16H30/20
摘要： Presented herein are systems and methods that facilitate user review and uploading of files comprising medical images and associated metadata from a local computing device to a network-based image analysis and/or decision support platform. The systems and methods described herein allow image upload to be performed in a secure fashion that prevents the network-based platform from accessing sensitive data as it is prepared for upload. Prior to file upload, sensitive data elements are flagged and their values removed and/or masked. Notably, the approaches described herein provide intuitive graphical user interface (GUI) tools that allow a user, such as a medical practitioner or researcher, to review not only the images and metadata in the files that they plan to upload, but also to review and control the process by which sensitive data elements are removed and/masked, thereby confirming that all files are free of sensitive information prior to upload.
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公开(公告)号：US10973486B2
公开(公告)日：2021-04-13
申请号：US16003006
申请日：2018-06-07
发明人： Karl Vilhelm Sjöstrand , Jens Filip Andreas Richter , Kerstin Elsa Maria Johnsson , Erik Konrad Gjertsson
IPC分类号： G06K9/46 , A61B6/00 , G06T7/00 , G06T5/30 , A61B6/03 , A61K51/04 , G06T15/08 , G06T7/143 , G06T7/11 , G06N3/08 , G06F3/0484 , G06N3/04
摘要： Presented herein are systems and methods that provide for automated analysis of three-dimensional (3D) medical images of a subject in order to automatically identify specific 3D volumes within the 3D images that correspond to specific organs and/or tissue. In certain embodiments, the accurate identification of one or more such volumes can be used to determine quantitative metrics that measure uptake of radiopharmaceuticals in particular organs and/or tissue regions. These uptake metrics can be used to assess disease state in a subject, determine a prognosis for a subject, and/or determine efficacy of a treatment modality.
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4.发明申请公开(公告)号：US20190209116A1
公开(公告)日：2019-07-11
申请号：US16003006
申请日：2018-06-07
发明人： Karl Vilhelm Sjöstrand , Jens Filip Andreas Richter , Kerstin Elsa Maria Johnsson , Erik Konrad Gjertsson
CPC分类号： A61B6/5217 , A61B6/037 , A61B6/465 , A61B6/466 , A61B6/467 , A61B6/50 , A61B6/5223 , A61B6/5229 , A61B6/5258 , A61K51/0478 , G06F3/04842 , G06K9/4647 , G06K2209/051 , G06N3/04 , G06N3/0454 , G06N3/08 , G06T5/30 , G06T7/0014 , G06T15/08 , G06T2200/24 , G06T2207/10108 , G06T2207/30081 , G06T2207/30096
摘要： Presented herein are systems and methods that provide for automated analysis of three-dimensional (3D) medical images of a subject in order to automatically identify specific 3D volumes within the 3D images that correspond to specific organs and/or tissue. In certain embodiments, the accurate identification of one or more such volumes can be used to determine quantitative metrics that measure uptake of radiopharmaceuticals in particular organs and/or tissue regions. These uptake metrics can be used to assess disease state in a subject, determine a prognosis for a subject, and/or determine efficacy of a treatment modality.
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公开(公告)号：US09669096B2
公开(公告)日：2017-06-06
申请号：US14039866
申请日：2013-09-27
发明人： Suketu P. Sanghvi , Thomas A. Boyd
IPC分类号： A61K31/485 , A61K47/02 , A61K9/00 , A61K9/19 , A61K31/047 , A61K31/195 , A61K45/06 , A61K47/12 , A61K47/18
CPC分类号： A61K47/02 , A61K9/0019 , A61K9/19 , A61K31/047 , A61K31/195 , A61K31/485 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/183 , A61K2300/00
摘要： Stable pharmaceutical compositions useful for administering methylnaltrexone are described, as are methods for making the same. Kits, including these pharmaceutical compositions, also are provided.
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公开(公告)号：US20040224308A1
公开(公告)日：2004-11-11
申请号：US10780993
申请日：2004-02-18
IPC分类号： C12Q001/70 , C07H021/04 , C12N007/00 , C07K014/16 , C12N015/867
CPC分类号： C07K14/005 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2740/16023 , C12N2740/16122
摘要： This invention provides an isolated nucleic acid which comprises a nucleotide segment having a sequence encoding a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention also provides a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention further provides methods of treating HIV-1 infection.
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7.发明公开公开(公告)号：US20240285248A1
公开(公告)日：2024-08-29
申请号：US18530831
申请日：2023-12-06
CPC分类号： A61B6/5217 , A61B6/032 , A61B6/037 , A61B6/50 , A61B6/5235 , A61B6/563 , G06T7/0012 , G06T7/11 , G16H50/30 , G06T2207/10081 , G06T2207/10104 , G06T2207/20081 , G06T2207/20084 , G06T2207/30081 , G06T2207/30096
摘要： Presented herein are systems and methods for predicting biochemical progression free survival (bPFS) in prostate cancer patients. In certain embodiments, bPFS is predicted from 18F-DCFPyL PET/CT images using deep learning (or other machine learning or artificial intelligence techniques) to segment anatomical information from the CT image and use this information in combination with the PET image to detect and quantify candidates for prostate cancer lesions.
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公开(公告)号：US12032722B2
公开(公告)日：2024-07-09
申请号：US18072000
申请日：2022-11-30
IPC分类号： G16H30/20 , G06F3/0482 , G06F16/58 , G06F21/62 , H04L9/40
CPC分类号： G06F21/6254 , G06F3/0482 , G06F16/5866 , G16H30/20 , H04L63/20
摘要： Presented herein are systems and methods that facilitate user review and uploading of files comprising medical images and associated metadata from a local computing device to a network-based image analysis and/or decision support platform. The systems and methods described herein allow image upload to be performed in a secure fashion that prevents the network-based platform from accessing sensitive data as it is prepared for upload. Prior to file upload, sensitive data elements are flagged and their values removed and/or masked. Notably, the approaches described herein provide intuitive graphical user interface (GUI) tools that allow a user, such as a medical practitioner or researcher, to review not only the images and metadata in the files that they plan to upload, but also to review and control the process by which sensitive data elements are removed and/masked, thereby confirming that all files are free of sensitive information prior to upload.
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9.发明公开公开(公告)号：US20240186010A1
公开(公告)日：2024-06-06
申请号：US18543113
申请日：2023-12-18
发明人： Mark R. Baker
摘要： Described herein is a platform and supported graphical user interface (GUI) decision-making tools for use by medical practitioners and/or their patients, e.g., to aide in the process of making decisions about a course of cancer treatment and/or to track treatment and/or the progress of a disease.
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10.发明公开公开(公告)号：US20240127437A1
公开(公告)日：2024-04-18
申请号：US18398846
申请日：2023-12-28
CPC分类号： G06T7/0012 , G06V10/25 , G16H30/40 , G16H50/20 , G06T2207/10081
摘要： Presented herein are systems and methods that provide for automated analysis of medical images to determine a predicted disease status (e.g., prostate cancer status) and/or a value corresponding to predicted risk of the disease status for a subject. The approaches described herein leverage artificial intelligence (AI) to analyze intensities of voxels in a functional image, such as a PET image, and determine a risk and/or likelihood that a subject's disease, e.g., cancer, is aggressive. The approaches described herein can provide predictions of whether a subject that presents a localized disease has and/or will develop aggressive disease, such as metastatic cancer. These predictions are generated in a fully automated fashion and can be used alone, or in combination with other cancer diagnostic metrics (e.g., to corroborate predictions and assessments or highlight potential errors). As such, they represent a valuable tool in support of improved cancer diagnosis and treatment.
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